Immunology

Eosinophils secrete plasminogen activator inhibitor-2

Published in Cancer Weekly, December 14th, 2004

Plasminogen activator inhibitor-2 (PAI-2) is secreted by eosinophilic leukocytes.

Previously, PAI-2 "as a potential eosinophil protein was inferred" from a "gene microarray study of mouse eosinophilopoiesis" conducted by researchers in the United States.

In their subsequent study, J.M. Swartz and coauthors at the National Institute of Allergy and Infectious Diseases identified "47 kDa intracellular and approximately 60 kDa secretory forms of PAI-2 in purified human eosinophil extracts."

"PAI-2 is present at variable concentrations in eosinophil lysates, ranging from 30 to 444 ng/10⁶ cells, with a mean of 182...

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Source: Cancer Weekly (2004-12-14)

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