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Reduced-Intensity Stem Cell Transplantation

NCI Common Toxicity Criteria is appropriate in toxicity evaluation of RIST

Published in Cancer Weekly, December 21st, 2004

The U.S. National Cancer Institute Common Toxicity Criteria are appropriate in toxicity evaluation of reduced-intensity stem-cell transplantation.

According to a study from Japan, "Acute regimen-related toxicity (RRT) is minimal in reduced-intensity stem-cell transplantation (RIST). However, the Seattle RRT grading (Bearman et al), developed in the context of conventional-intensity transplantation, is frequently applied to RIST."

"We compared the National Cancer Institute Common Toxicity Criteria (NCI-CTC) version 2.0 with the Seattle criteria after RIST in 86 patients. RRT within 30 days of transplant graded by both sets of criteria were...

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