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Cancer Weekly

Susan Hasty, Publisher
Table of Contents . . . December 28th, 2004
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Cancer Weekly | Other Publications

Breast Cancer - Scientists find way to see breast cancer activity from outside the body

Colorectal Cancer - Association of nut and seed intake with cancer risk studied

Esophageal Cancer - Genes involved in zinc-induced tumor cell apoptosis identified

Gynecology - Simultaneous blockade of Bcl-2 and DNA repair staunches ovarian cancer growth

Lung Cancer - Potential genetic biomarkers of NSCLC identified

Acute Lymphoblastic Leukemia - U.S. FDA committee recommends accelerated clofarabine approval for ALL

Acute Myeloid Leukemia - Real-time RT-PCR assay monitors DEK-CAN fusion transcripts in AML

Alcoholism - Study provides clues to alcohol's cancer connection

Apoptosis - Cannabinoid dexanabinol inhibits NF-kappa B

Apoptosis - The FS-E domain of the glycoprotein SPARC inhibits tumor angiogenesis

Apoptosis - p53-dependent replication checkpoint is defective in cancer cells

Arthritis - The benefit/risk ratio for anti-TNF-alpha agents has been favorable

Awards - Breast cancer foundation names 2004 award recipients for scientific distinction

Awards - Japanese researcher awarded 2-year fellowship to continue brain tumor research

Bladder Cancer - Hexvix marketing application for bladder cancer diagnosis authorized in Europe

Bone Marrow Transplantation - Selective amplifier genes allow gene transduction without marrow conditioning

Bowel Cancer - Higher selenium intake may protect against bowel cancer, report shows

Brain Cancer - Cytokine gene therapy may overcome common barriers to glioma immunotherapy

Brain Cancer - New GLIADEL Wafer data presented at SNO meeting

Brain Cancer - Small protein slows the growth of glioblastoma multiforme

Brain Cancer - U.S. FDA grants orphan drug status to monoclonal antibody for brain cancer

Breast Cancer - ATAC trial data reported comparing anastrozole to tamoxifen

Breast Cancer - Analysis demonstrates additional benefits of adjuvant therapy with clodronate

Breast Cancer - Anastrozole benefits confirmed in postmenopausal patients

Breast Cancer - Approval sought for exemestane tablets as therapy for postmenopausal women

Breast Cancer - Biomarker expression correlates with 80% recurrence rate in retrospective study

Breast Cancer - Celecoxib shows surprising activity against estrogen receptors

Breast Cancer - Cell marker identifies patients more likely to respond to Taxol

Breast Cancer - Combination neoadjuvant therapy promising in treating locally advanced cancer

Breast Cancer - Conservation surgery is an option in ILC cases with clearly defined margins

Breast Cancer - Cystatin M is a novel candidate tumor suppressor gene for breast cancer

Breast Cancer - Data indicate nodal sampling or dissection is unnecessary in DCIS cases

Breast Cancer - Data re-analysis shows greatest benefit of chemotherapy in ER-negative tumors

Breast Cancer - Data show epirubicin hydrochloride injection improves survival

Breast Cancer - Digital mammography system provides benefits

Breast Cancer - Grant enables study of stress management in breast cancer patients

Breast Cancer - Hormone therapy alone isn't best treatment for receptor-positive cancer

Breast Cancer - MRI useful for detection, but doesn't eliminate need for biopsy

Breast Cancer - MammoSite Radiation Therapy System distributor announced

Breast Cancer - Market release of breast biopsy device announced

Breast Cancer - Medical imaging systems developer receives Frost & Sullivan technology award

Breast Cancer - Microarray-based diagnostic test has reached level 3 in evidence-based medicine

Breast Cancer - Molecular test predicts recurrence risk and who will benefit from chemotherapy

Breast Cancer - More research needed to clarify etiologic role of hormone-receptor expression

Breast Cancer - New drug shows better results at preventing return of disease

Breast Cancer - New molecular classification predicts response to chemotherapy

Breast Cancer - Peer-reviewed journal includes articles on breast ductoscopy product

Breast Cancer - Program makes breast cancer information more accessible

Breast Cancer - Selective loss of AKR1C1/2 may result in decreased progesterone catabolism

Breast Cancer - Shortening standard radiation therapy course following lumpectomy under study

Breast Cancer - Stat3 upregulates MEK5 expression in breast tumor cells

Breast Cancer - Steroid identified as an independent prognostic marker in breast cancer

Breast Cancer - Study: Aromatase inhibitors should be first-line treatment

Breast Cancer - Study: Folate supplements during pregnancy may increase long-term cancer risk

Breast Cancer - Validation study paves way for large-scale trial of personalized therapy

Breast Cancer - Zoledronic acid prevents bone loss in patients treated with hormone therapy

Business & Finance - Pharma company announces financial results

Business Update - Perfusion-technology company reports activities during third-quarter 2004

Cancer - Cancer biology company collaborates with ACLARA on cancer biomarkers

Cancer Awareness - Display of hats meant to increase awareness of brain tumors

Cancer Epidemiology - European study highlights increase in childhood cancer over past 3 decades

Cancer Genetics - Editorial highlights issues facing acceptance of cancer genetics uses

Cancer Genetics - Mutation panel described for screening BRCA1/2 mutations in French Canadians

Cancer Genetics - Penetrance functions for software predicts cancer risk among BRCA1/2 carriers

Cancer Prognosis - Protein levels associated with remission, survival

Cancer Research - Avastin plus the FOLFOX4 study achieved primary endpoint of overall survival

Cancer Research - Biopharma company presents study results for anticancer agent at conference

Cancer Research - Genasense Injection for multiple myeloma trial did not reach primary end-point

Cancer Research - HSPB9 is a cancer/testis antigen; it may interact with dynein subunit TCTEL1

Cancer Research - Pharma company announces manuscript publication for anticancer drug

Cancer Research - VELCADE data presented at hematology meeting

Cancer Therapy - Blocked thymidine phosphorylase augments paclitaxel efficacy in prostate cancer

Cancer Therapy - Data shows Aranesp every 2 weeks is comparable once-a-week dose

Cancer Therapy - First patient given dose in phase I study of LErafAON

Cancer Therapy - IND application submitted for AVR118

Cancer Therapy - Radiation-guided drug delivery to tumor microvasculature effective in mice

Cancer Therapy - Scientists determine how "trump card" protein blocks DNA replication

Cancer Therapy - The cytotoxic effect of paclitaxel does not involve apoptosis completion

Cancer Treatment - MammoTest Breast Biopsy System cleared as platform for breast brachytherapy

Cancer Vaccine - Mycobacterium vaccae modulates monocyte-tumor cell interactions

Cancer Vaccine - CD4+ T cells kill Id+ B-lymphoma cells

Cancer Vaccine - Cytotoxic T cell responses toward NY-ESO-1 protein examined

Cancer Vaccine - DNA methyltransferase peptide induces tumor-directed cytotoxic T cells

Cancer Vaccine - Dendritic cell-tumor cell vaccination benefits metastatic cancer patients

Cancer Vaccine - Dendritic cells that capture dead tumor cells secrete IL-12 and TNF-alpha

Cancer Vaccine - HSVVP22 protein translocation presents tumor antigen to dendritic cells

Cancer Vaccine - IL-12 up-regulates lymphokine-activated killer activity

Cancer Vaccine - Low-frequency human antigen-specific CD4+ T cells detected

Cancer Vaccine - Translocation of foreign antigens by Yersinia leads to T-cell priming

Candidiasis Vaccine - C. albicans antigens identified to diagnose systemic candidiasis

Cell Biology - DNA damage-induced centrosome amplification characterized

Cervical Cancer - HPV genotyping of high-grade SIL may have prognostic value

Cervical Cancer - Immunohistochemical expression of 14-3-3sigma protein studied

Cervical Cancer - Proteomic approach used to study cisplatin resistance in human cell lines

Cervical Cancer - Study looks at risk factors for invasive disease among HPV-exposed women

Cervical Cancer - Vaccine candidate for precancerous cervical lesions in new phase 2 trial

Chemotherapy - I-Flow enters national agreement with Aetna for InfuSystem service

Chemotherapy - Mathematical model predicts time to neutrophil recovery after HD chemotherapy

Clinical Pipeline Update - Lung cancer trial on track; brain and breast cancer studies underway

Clinical Trials - Phase 1 clinical trial for non-Hodgkin lymphoma antibody treatment expanded

Collaboration - Biopharm company enters agreement with Tulane U. for growth hormone development

Collaborations - Alliance to develop Anti-CD22/Onconase conjugate

Collaborations - Celltech collaborates on magnetotherapy technology

Colorectal Cancer - Cancer drug shown to improve survival in metastatic colorectal cancer regimens

Colorectal Cancer - Data show ELOXATIN-based therapy combined with Bevacizumab improves survival

Colorectal Cancer - Shikonin induces apoptosis in colorectal carcinoma cells

Diagnostic Imaging - Vaccinia virus expressing SSTR2 permits noninvasive tumor imaging

Diagnostics - Cancer diagnostics company announces new biopsy probes

Diagnostics - Company commences ComfortScan trials for final module of PMA

Diagnostics - Company gets California license for new advanced cancer diagnostics laboratory

Diagnostics - SenoScan2 digital mammography system launched

Diagnostics - Serum contains preneoplastic markers for hepatitis B virus-related liver cancer

Drug Addiction - Clinical trials for agent to treat methamphetamine addiction initiated

Drug Delivery - Liposome encapsulation improves anticancer activity of flavonoids

Drug Delivery - Thermosensitive liposomes supply rapid doxorubicin release in tumor vessels

Drug Development - Anti-PTHrP antibody may attenuate humoral hypercalcemia of malignancy

Drug Development - Mulberry extract has potent activity against skin tumors in mice

Drug Development - Prooxidant activity of indole-3-acetic acid derivative radicals determined

Finance - Pharma company closes fourth round of private financing

Finance - Pharma company releases financial results

Fitness & Wellness - USDA data show that peanuts can be Mother Nature's multivitamin

Fundraising - 2005 Playtex Moonwalk to raise money to fight breast cancer opens in London

Gastroenterology - PillCam ESO receives marketing clearance from U.S. FDA

Gastroenterology - Rofecoxib and octreotide combine to stop gastric cancer cell proliferation

Gastroenterology - Viral vector-mediated endostatin transfer halts pancreatic cancer growth

Gastrointestinal Stromal Cancer - Human telomerase reverse transcriptase may have prognostic value

Gastrointestinal Stromal Tumors - Tumor size alone not always best for gauging treatment response

Gene Promotion - Two-step transcriptional amplification-based vectors ease transgene scrutiny

Gene Silencing - RNA interference blocks a key protein that stabilizes tumor vessels

Genomics - High-throughput mutation detection study on E. Coli published

HIV/AIDS-Related Kaposi Sarcoma - Injection drug use not associated with increased risk of AIDS-related KS

Hematological Malignancies - MorphoSys-generated antibody approved to enter clinical trials

Hematology - The pleiotropic effects of erythropoietin warrant more analysis

Hematopoiesis - Interferon alpha treatment of bone marrow stroma inhibits hematopoiesis

Hepatocellular Carcinoma - Percutaneous ethanol injection is effective therapy for liver cancer patients

Herceptin Therapy - Study: Efficacy of Herceptin therapy is influenced by several factors

Human Papillomavirus - Lactoferrin inhibits HPV binding and uptake in vitro

Idiopathic Thrombocytopenic Purpura - Idiopathic thrombocytopenic purpura will resolve with ongoing follow-up

Imaging - Lung and gastrointestinal cancer detection device installed in Canada practice

Imaging - Prostate cancer imaging advances presented at conference

Imaging - Technology company introduces ImageChecker DMax CAD

Intestinal Cancer - Epiregulin deficiency does not alter intestinal cancer susceptibility

Kaposi Sarcoma-Associated Herpesvirus - Defective KSHV is present in KS tumors and primary effusion lymphoma cells

Kaposi Sarcoma-Associated Herpesvirus - KSHV latent nuclear antigen disruption leads to abortive episome persistence

Leukemia - Farnesyl transferase inhibitor can help patients at high risk for developing AML

Leukemia - Half of relapsed CLL patients respond to two biologics with chemotherapy

Leukemia - Haploidentical killer cells may provide hope for some patients with AML

Leukemia - Peptide vaccine can produce complete remission in myeloid leukemia patients

Lung Cancer - First stage of phase 2 study for non-small cell lung cancer completed

Lung Cancer - Funding foundation study finds 2 of 3 Americans touched by lung cancer

Lung Cancer - Lung cancer survival statistics reported in trial using radiofrequency ablation

Malignant Glioma - Anticancer vaccine doubles time-to-disease progression, increases survival

Mammography - Digital mammography reduces recall rates 40%, improves diagnostics, study shows

Medical Devices - New pump for radiofrequency ablation system introduced

Medical Devices - Ultrasound system to thermally ablate tissue for no-incision surgery introduced

Medical Imaging - Imaging equipment maker introduces compact system for low-use mammography sites

Medical Imaging - Imaging software developer announces upgrade to radiology utility system

Medical Imaging - Imaging systems maker announces new technologies, programs

Medical Imaging - Virtual colonoscopy raises issues of concern, gastrointestinal society says

Metastasis - High-throughput methods measure heparanase activity and screen for therapy

Multiple Myeloma - Aplidin granted orphan drug status by European Commission

Multiple Myeloma - Scientists stalk PPAR-gamma, find novel cancer connection

Multiple Myeloma - Stem cell transplantation drug candidate evaluated in multiple myeloma patients

Multiple Myeloma - U.S. FDA accepts sNDA filing with priority review for VELCADE for myeloma

Mutagenesis - Concurrent gene and protein analyses expose p53 status in liver cancer patients

Mutagenesis - HLA-E polymorphism may contribute to the formation of nasopharyngeal carcinoma

Nasopharyngeal Cancer - Pro-apoptotic Bim_s treats and prevents xenografted tumors

Non-Hodgkin Lymphoma - ODAC votes against accelerated approval for Marqibo in non-Hodgkin lymphoma

Non-Small Cell Lung Cancer - Patient enrollment completed for HGS-ETR1 trial in non-small cell lung cancer

Oncology - A new fusion gene construct strengthens the efforts of lymphoma chemotherapy

Oncology - Eleven studies evaluating ThinPrep Imaging System presented at meeting

Oncology - Mechanisms of tumor suppressor RASSF1A elucidated

Oncology - Pharma companies announce oncology therapeutics research milestone

Oncology - Pharmaceutical company confirms, first to market Paxene in Spain

Oncology - Single-stranded oligonucleotides targeting STAT3 destroy prostate cancer

Oncology - Synthetic Grb2-SH2 domain binding antagonists staunch tumor and vessel growth

Oral Mucositis - Company receives fast-track designation for CG53135

Osteoporosis - Foundation endorses Surgeon General's report on osteoporosis

Osteoporosis - Software developer includes osteoporosis testing on MicroDose Mammography system

Ovarian Cancer - Potential ovarian cancer susceptibility allele of low penetrance identified

Ovarian Cancer - Study finds evidence for increased cancer risk due to perineal talc exposure

Pancreatic Cancer - Putative amplification target genes identified

Pancreatic Cancer - U.S. FDA allows 90-day extension of review date for pancreatic cancer NDA

Patents - Maker of microarrays for genomic research gets patent for dispensing technology

Patents - Patent covers therapeutic use of VEGFR antibody with radiation or chemotherapy

Patents - U.S. Patent and Trademark Office finds HPV-related application is 'patentable'

Patents - U.S. Patent covering protein formulations of engineered zinc fingers granted

Personnel - Biopharma company names senior vice president commercial operations

Personnel - Biopharmaceutical company names vice president business development

Personnel - Steven Kelly named president, CEO of oncology-focused pharmaceutical company

Philanthropy - Moyer Foundation donates $1.5 million for early-detection cancer research

Prostate Cancer - Data on satraplatin presented at AACR prostate cancer meeting

Prostate Cancer - European study on prostate brachytherapy demonstrates value of treatment option

Prostate Cancer - Imagent results in prostate cancer detection presented at meeting

Prostate Cancer - Metastatic hormone-refractory prostate cancer treatment trial results reported

Protein Regulation - Tinospora cordifolia harnesses the power of cytokines to stop angiogenesis

Recombinant Research - The recombinant protein fibstatin is a potent suppressor of angiogenesis

Renal Cancer - Endostatin treatment targets several genes in renal cell carcinomas

Skin Cancer - Add an "E" to the alphabet for identifying melanoma

Skin Cancer - Childhood vaccinations offer protection against melanoma

Skin Cancer - Stressed mice quicker to get skin cancer

Skin Cancer - p53 point mutation at Ser389 increases sensitivity to UV radiation

Smoking Cessation - Two decades after Nicorette's introduction, a change is offered for smokers

Solid Tumors - Patient treatment commences in European phase I clinical trial of IMC-11F8

Stem Cell Research - Distinct cell "side population" has high drug efflux capacity in tumor cells

Survival and Mortality - VEGF-A expression is a prognostic marker for angioimmunoblastic T-cell lymphoma

Thalidomide - Thalidomide associated with adverse effects in patients with neoplastic diseases

Thrombosis - Prevalence of hereditary thrombophilic factors in portal vein thrombosis studied

Tobacco Use - Growing number of college students taking up smoking, research shows

Tobacco Use - One in five pregnant women in South Dakota smokes

Tobacco Use - Tobacco treaty becoming law is making global public health history

Tranplant Medicine - Researchers set new standard of care for adult cord blood transplant patients

Vaccine Development - Fused heat shock proteins do not guarantee the success of DNA vaccines

Varicella Zoster Virus Infection - Severe abdominal pain is important sign of VZV infection in SCT recipients

Vascular Neoplasia - ERbeta is expressed in benign and malignant vascular neoplasia

Virology - Lentiviral transduction of cord SCs yields high-level beta-globin expression

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