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Table of Contents . . . December 28th, 2004
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Cancer Weekly | Other Publications
Breast Cancer - Scientists find way to see breast cancer activity from outside the body
Colorectal Cancer - Association of nut and seed intake with cancer risk studied
Esophageal Cancer - Genes involved in zinc-induced tumor cell apoptosis identified
Gynecology - Simultaneous blockade of Bcl-2 and DNA repair staunches ovarian cancer growth
Lung Cancer - Potential genetic biomarkers of NSCLC identified
Acute Lymphoblastic Leukemia - U.S. FDA committee recommends accelerated clofarabine approval for ALL
Acute Myeloid Leukemia - Real-time RT-PCR assay monitors DEK-CAN fusion transcripts in AML
Alcoholism - Study provides clues to alcohol's cancer connection
Apoptosis - Cannabinoid dexanabinol inhibits NF-kappa B
Apoptosis - The FS-E domain of the glycoprotein SPARC inhibits tumor angiogenesis
Apoptosis - p53-dependent replication checkpoint is defective in cancer cells
Arthritis - The benefit/risk ratio for anti-TNF-alpha agents has been favorable
Awards - Breast cancer foundation names 2004 award recipients for scientific distinction
Awards - Japanese researcher awarded 2-year fellowship to continue brain tumor research
Bladder Cancer - Hexvix marketing application for bladder cancer diagnosis authorized in Europe
Bone Marrow Transplantation - Selective amplifier genes allow gene transduction without marrow conditioning
Bowel Cancer - Higher selenium intake may protect against bowel cancer, report shows
Brain Cancer - Cytokine gene therapy may overcome common barriers to glioma immunotherapy
Brain Cancer - New GLIADEL Wafer data presented at SNO meeting
Brain Cancer - Small protein slows the growth of glioblastoma multiforme
Brain Cancer - U.S. FDA grants orphan drug status to monoclonal antibody for brain cancer
Breast Cancer - ATAC trial data reported comparing anastrozole to tamoxifen
Breast Cancer - Analysis demonstrates additional benefits of adjuvant therapy with clodronate
Breast Cancer - Anastrozole benefits confirmed in postmenopausal patients
Breast Cancer - Approval sought for exemestane tablets as therapy for postmenopausal women
Breast Cancer - Biomarker expression correlates with 80% recurrence rate in retrospective study
Breast Cancer - Celecoxib shows surprising activity against estrogen receptors
Breast Cancer - Cell marker identifies patients more likely to respond to Taxol
Breast Cancer - Combination neoadjuvant therapy promising in treating locally advanced cancer
Breast Cancer - Conservation surgery is an option in ILC cases with clearly defined margins
Breast Cancer - Cystatin M is a novel candidate tumor suppressor gene for breast cancer
Breast Cancer - Data indicate nodal sampling or dissection is unnecessary in DCIS cases
Breast Cancer - Data re-analysis shows greatest benefit of chemotherapy in ER-negative tumors
Breast Cancer - Data show epirubicin hydrochloride injection improves survival
Breast Cancer - Digital mammography system provides benefits
Breast Cancer - Grant enables study of stress management in breast cancer patients
Breast Cancer - Hormone therapy alone isn't best treatment for receptor-positive cancer
Breast Cancer - MRI useful for detection, but doesn't eliminate need for biopsy
Breast Cancer - MammoSite Radiation Therapy System distributor announced
Breast Cancer - Market release of breast biopsy device announced
Breast Cancer - Medical imaging systems developer receives Frost & Sullivan technology award
Breast Cancer - Microarray-based diagnostic test has reached level 3 in evidence-based medicine
Breast Cancer - Molecular test predicts recurrence risk and who will benefit from chemotherapy
Breast Cancer - More research needed to clarify etiologic role of hormone-receptor expression
Breast Cancer - New drug shows better results at preventing return of disease
Breast Cancer - New molecular classification predicts response to chemotherapy
Breast Cancer - Peer-reviewed journal includes articles on breast ductoscopy product
Breast Cancer - Program makes breast cancer information more accessible
Breast Cancer - Selective loss of AKR1C1/2 may result in decreased progesterone catabolism
Breast Cancer - Shortening standard radiation therapy course following lumpectomy under study
Breast Cancer - Stat3 upregulates MEK5 expression in breast tumor cells
Breast Cancer - Steroid identified as an independent prognostic marker in breast cancer
Breast Cancer - Study: Aromatase inhibitors should be first-line treatment
Breast Cancer - Study: Folate supplements during pregnancy may increase long-term cancer risk
Breast Cancer - Validation study paves way for large-scale trial of personalized therapy
Breast Cancer - Zoledronic acid prevents bone loss in patients treated with hormone therapy
Business & Finance - Pharma company announces financial results
Business Update - Perfusion-technology company reports activities during third-quarter 2004
Cancer - Cancer biology company collaborates with ACLARA on cancer biomarkers
Cancer Awareness - Display of hats meant to increase awareness of brain tumors
Cancer Epidemiology - European study highlights increase in childhood cancer over past 3 decades
Cancer Genetics - Editorial highlights issues facing acceptance of cancer genetics uses
Cancer Genetics - Mutation panel described for screening BRCA1/2 mutations in French Canadians
Cancer Genetics - Penetrance functions for software predicts cancer risk among BRCA1/2 carriers
Cancer Prognosis - Protein levels associated with remission, survival
Cancer Research - Avastin plus the FOLFOX4 study achieved primary endpoint of overall survival
Cancer Research - Biopharma company presents study results for anticancer agent at conference
Cancer Research - Genasense Injection for multiple myeloma trial did not reach primary end-point
Cancer Research - HSPB9 is a cancer/testis antigen; it may interact with dynein subunit TCTEL1
Cancer Research - Pharma company announces manuscript publication for anticancer drug
Cancer Research - VELCADE data presented at hematology meeting
Cancer Therapy - Blocked thymidine phosphorylase augments paclitaxel efficacy in prostate cancer
Cancer Therapy - Data shows Aranesp every 2 weeks is comparable once-a-week dose
Cancer Therapy - First patient given dose in phase I study of LErafAON
Cancer Therapy - IND application submitted for AVR118
Cancer Therapy - Radiation-guided drug delivery to tumor microvasculature effective in mice
Cancer Therapy - Scientists determine how "trump card" protein blocks DNA replication
Cancer Therapy - The cytotoxic effect of paclitaxel does not involve apoptosis completion
Cancer Treatment - MammoTest Breast Biopsy System cleared as platform for breast brachytherapy
Cancer Vaccine - Mycobacterium vaccae modulates monocyte-tumor cell interactions
Cancer Vaccine - CD4+ T cells kill Id+ B-lymphoma cells
Cancer Vaccine - Cytotoxic T cell responses toward NY-ESO-1 protein examined
Cancer Vaccine - DNA methyltransferase peptide induces tumor-directed cytotoxic T cells
Cancer Vaccine - Dendritic cell-tumor cell vaccination benefits metastatic cancer patients
Cancer Vaccine - Dendritic cells that capture dead tumor cells secrete IL-12 and TNF-alpha
Cancer Vaccine - HSVVP22 protein translocation presents tumor antigen to dendritic cells
Cancer Vaccine - IL-12 up-regulates lymphokine-activated killer activity
Cancer Vaccine - Low-frequency human antigen-specific CD4+ T cells detected
Cancer Vaccine - Translocation of foreign antigens by Yersinia leads to T-cell priming
Candidiasis Vaccine - C. albicans antigens identified to diagnose systemic candidiasis
Cell Biology - DNA damage-induced centrosome amplification characterized
Cervical Cancer - HPV genotyping of high-grade SIL may have prognostic value
Cervical Cancer - Immunohistochemical expression of 14-3-3sigma protein studied
Cervical Cancer - Proteomic approach used to study cisplatin resistance in human cell lines
Cervical Cancer - Study looks at risk factors for invasive disease among HPV-exposed women
Cervical Cancer - Vaccine candidate for precancerous cervical lesions in new phase 2 trial
Chemotherapy - I-Flow enters national agreement with Aetna for InfuSystem service
Chemotherapy - Mathematical model predicts time to neutrophil recovery after HD chemotherapy
Clinical Pipeline Update - Lung cancer trial on track; brain and breast cancer studies underway
Clinical Trials - Phase 1 clinical trial for non-Hodgkin lymphoma antibody treatment expanded
Collaboration - Biopharm company enters agreement with Tulane U. for growth hormone development
Collaborations - Alliance to develop Anti-CD22/Onconase conjugate
Collaborations - Celltech collaborates on magnetotherapy technology
Colorectal Cancer - Cancer drug shown to improve survival in metastatic colorectal cancer regimens
Colorectal Cancer - Data show ELOXATIN-based therapy combined with Bevacizumab improves survival
Colorectal Cancer - Shikonin induces apoptosis in colorectal carcinoma cells
Diagnostic Imaging - Vaccinia virus expressing SSTR2 permits noninvasive tumor imaging
Diagnostics - Cancer diagnostics company announces new biopsy probes
Diagnostics - Company commences ComfortScan trials for final module of PMA
Diagnostics - Company gets California license for new advanced cancer diagnostics laboratory
Diagnostics - SenoScan2 digital mammography system launched
Diagnostics - Serum contains preneoplastic markers for hepatitis B virus-related liver cancer
Drug Addiction - Clinical trials for agent to treat methamphetamine addiction initiated
Drug Delivery - Liposome encapsulation improves anticancer activity of flavonoids
Drug Delivery - Thermosensitive liposomes supply rapid doxorubicin release in tumor vessels
Drug Development - Anti-PTHrP antibody may attenuate humoral hypercalcemia of malignancy
Drug Development - Mulberry extract has potent activity against skin tumors in mice
Drug Development - Prooxidant activity of indole-3-acetic acid derivative radicals determined
Finance - Pharma company closes fourth round of private financing
Finance - Pharma company releases financial results
Fitness & Wellness - USDA data show that peanuts can be Mother Nature's multivitamin
Fundraising - 2005 Playtex Moonwalk to raise money to fight breast cancer opens in London
Gastroenterology - PillCam ESO receives marketing clearance from U.S. FDA
Gastroenterology - Rofecoxib and octreotide combine to stop gastric cancer cell proliferation
Gastroenterology - Viral vector-mediated endostatin transfer halts pancreatic cancer growth
Gastrointestinal Stromal Cancer - Human telomerase reverse transcriptase may have prognostic value
Gastrointestinal Stromal Tumors - Tumor size alone not always best for gauging treatment response
Gene Promotion - Two-step transcriptional amplification-based vectors ease transgene scrutiny
Gene Silencing - RNA interference blocks a key protein that stabilizes tumor vessels
Genomics - High-throughput mutation detection study on E. Coli published
HIV/AIDS-Related Kaposi Sarcoma - Injection drug use not associated with increased risk of AIDS-related KS
Hematological Malignancies - MorphoSys-generated antibody approved to enter clinical trials
Hematology - The pleiotropic effects of erythropoietin warrant more analysis
Hematopoiesis - Interferon alpha treatment of bone marrow stroma inhibits hematopoiesis
Hepatocellular Carcinoma - Percutaneous ethanol injection is effective therapy for liver cancer patients
Herceptin Therapy - Study: Efficacy of Herceptin therapy is influenced by several factors
Human Papillomavirus - Lactoferrin inhibits HPV binding and uptake in vitro
Idiopathic Thrombocytopenic Purpura - Idiopathic thrombocytopenic purpura will resolve with ongoing follow-up
Imaging - Lung and gastrointestinal cancer detection device installed in Canada practice
Imaging - Prostate cancer imaging advances presented at conference
Imaging - Technology company introduces ImageChecker DMax CAD
Intestinal Cancer - Epiregulin deficiency does not alter intestinal cancer susceptibility
Kaposi Sarcoma-Associated Herpesvirus - Defective KSHV is present in KS tumors and primary effusion lymphoma cells
Kaposi Sarcoma-Associated Herpesvirus - KSHV latent nuclear antigen disruption leads to abortive episome persistence
Leukemia - Farnesyl transferase inhibitor can help patients at high risk for developing AML
Leukemia - Half of relapsed CLL patients respond to two biologics with chemotherapy
Leukemia - Haploidentical killer cells may provide hope for some patients with AML
Leukemia - Peptide vaccine can produce complete remission in myeloid leukemia patients
Lung Cancer - First stage of phase 2 study for non-small cell lung cancer completed
Lung Cancer - Funding foundation study finds 2 of 3 Americans touched by lung cancer
Lung Cancer - Lung cancer survival statistics reported in trial using radiofrequency ablation
Malignant Glioma - Anticancer vaccine doubles time-to-disease progression, increases survival
Mammography - Digital mammography reduces recall rates 40%, improves diagnostics, study shows
Medical Devices - New pump for radiofrequency ablation system introduced
Medical Devices - Ultrasound system to thermally ablate tissue for no-incision surgery introduced
Medical Imaging - Imaging equipment maker introduces compact system for low-use mammography sites
Medical Imaging - Imaging software developer announces upgrade to radiology utility system
Medical Imaging - Imaging systems maker announces new technologies, programs
Medical Imaging - Virtual colonoscopy raises issues of concern, gastrointestinal society says
Metastasis - High-throughput methods measure heparanase activity and screen for therapy
Multiple Myeloma - Aplidin granted orphan drug status by European Commission
Multiple Myeloma - Scientists stalk PPAR-gamma, find novel cancer connection
Multiple Myeloma - Stem cell transplantation drug candidate evaluated in multiple myeloma patients
Multiple Myeloma - U.S. FDA accepts sNDA filing with priority review for VELCADE for myeloma
Mutagenesis - Concurrent gene and protein analyses expose p53 status in liver cancer patients
Mutagenesis - HLA-E polymorphism may contribute to the formation of nasopharyngeal carcinoma
Nasopharyngeal Cancer - Pro-apoptotic Bims treats and prevents xenografted tumors
Non-Hodgkin Lymphoma - ODAC votes against accelerated approval for Marqibo in non-Hodgkin lymphoma
Non-Small Cell Lung Cancer - Patient enrollment completed for HGS-ETR1 trial in non-small cell lung cancer
Oncology - A new fusion gene construct strengthens the efforts of lymphoma chemotherapy
Oncology - Eleven studies evaluating ThinPrep Imaging System presented at meeting
Oncology - Mechanisms of tumor suppressor RASSF1A elucidated
Oncology - Pharma companies announce oncology therapeutics research milestone
Oncology - Pharmaceutical company confirms, first to market Paxene in Spain
Oncology - Single-stranded oligonucleotides targeting STAT3 destroy prostate cancer
Oncology - Synthetic Grb2-SH2 domain binding antagonists staunch tumor and vessel growth
Oral Mucositis - Company receives fast-track designation for CG53135
Osteoporosis - Foundation endorses Surgeon General's report on osteoporosis
Osteoporosis - Software developer includes osteoporosis testing on MicroDose Mammography system
Ovarian Cancer - Potential ovarian cancer susceptibility allele of low penetrance identified
Ovarian Cancer - Study finds evidence for increased cancer risk due to perineal talc exposure
Pancreatic Cancer - Putative amplification target genes identified
Pancreatic Cancer - U.S. FDA allows 90-day extension of review date for pancreatic cancer NDA
Patents - Maker of microarrays for genomic research gets patent for dispensing technology
Patents - Patent covers therapeutic use of VEGFR antibody with radiation or chemotherapy
Patents - U.S. Patent and Trademark Office finds HPV-related application is 'patentable'
Patents - U.S. Patent covering protein formulations of engineered zinc fingers granted
Personnel - Biopharma company names senior vice president commercial operations
Personnel - Biopharmaceutical company names vice president business development
Personnel - Steven Kelly named president, CEO of oncology-focused pharmaceutical company
Philanthropy - Moyer Foundation donates $1.5 million for early-detection cancer research
Prostate Cancer - Data on satraplatin presented at AACR prostate cancer meeting
Prostate Cancer - European study on prostate brachytherapy demonstrates value of treatment option
Prostate Cancer - Imagent results in prostate cancer detection presented at meeting
Prostate Cancer - Metastatic hormone-refractory prostate cancer treatment trial results reported
Protein Regulation - Tinospora cordifolia harnesses the power of cytokines to stop angiogenesis
Recombinant Research - The recombinant protein fibstatin is a potent suppressor of angiogenesis
Renal Cancer - Endostatin treatment targets several genes in renal cell carcinomas
Skin Cancer - Add an "E" to the alphabet for identifying melanoma
Skin Cancer - Childhood vaccinations offer protection against melanoma
Skin Cancer - Stressed mice quicker to get skin cancer
Skin Cancer - p53 point mutation at Ser389 increases sensitivity to UV radiation
Smoking Cessation - Two decades after Nicorette's introduction, a change is offered for smokers
Solid Tumors - Patient treatment commences in European phase I clinical trial of IMC-11F8
Stem Cell Research - Distinct cell "side population" has high drug efflux capacity in tumor cells
Survival and Mortality - VEGF-A expression is a prognostic marker for angioimmunoblastic T-cell lymphoma
Thalidomide - Thalidomide associated with adverse effects in patients with neoplastic diseases
Thrombosis - Prevalence of hereditary thrombophilic factors in portal vein thrombosis studied
Tobacco Use - Growing number of college students taking up smoking, research shows
Tobacco Use - One in five pregnant women in South Dakota smokes
Tobacco Use - Tobacco treaty becoming law is making global public health history
Tranplant Medicine - Researchers set new standard of care for adult cord blood transplant patients
Vaccine Development - Fused heat shock proteins do not guarantee the success of DNA vaccines
Varicella Zoster Virus Infection - Severe abdominal pain is important sign of VZV infection in SCT recipients
Vascular Neoplasia - ERbeta is expressed in benign and malignant vascular neoplasia
Virology - Lentiviral transduction of cord SCs yields high-level beta-globin expression
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