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Apoptosis
p53-dependent replication checkpoint is defective in cancer cells
December 28th, 2004
The p53-dependent replication checkpoint is defective in cancer cells. According to a study from Italy, "Cdc7 is an evolutionarily conserved kinase that regulates S phase by promoting replication origin activation. "Down-regulation of Cdc7 by small interfering RNA in a variety of tumor cell lines causes an abortive S phase, leading to cell death by either p53-independent apoptosis or aberrant mitosis." "Unlike replication fork blockade," wrote A. Montagnoli and colleagues, "Cdc7-depleted tumor cells do not elicit a robust checkpoint response; thus, inhibitory signals preventing additional cell cycle progression are not...
Source: Cancer Weekly (2004-12-28)
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