Hematopoiesis
Interferon alpha treatment of bone marrow stroma inhibits hematopoiesis
Published in Cancer Weekly, December 28th, 2004
According to published research from Germany, "Prolonged pre-transplant IFN administration in patients with chronic myeloid leukemia has been associated with an increased risk of fatal transplant-related complications and an inferior outcome after allogeneic bone marrow transplantation."
"Using a two-stage long-term bone marrow culture as an in vitro model we were able to show a negative effect of higher doses of IFN pre-treatment of bone marrow stroma on hematopoiesis. This correlated with a decline in the number of monocytes-macrophages," reported C. Kasper and...
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Source: Cancer Weekly (2004-12-28)
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