Cancer Weekly
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Bone Marrow Transplantation
Selective amplifier genes allow gene transduction without marrow conditioning
December 28th, 2004
Selective amplifier genes allow gene transduction without marrow conditioning. "The successful engraftment of genetically modified hematopoietic stem cells (HSCs) without toxic conditioning is a desired goal for HSC gene therapy. To this end, we have examined the combination of intrabone marrow transplantation (iBMT) and in vivo expansion by a selective amplifier gene (SAG) in a nonhuman primate model. The SAG is a chimeric gene consisting of the erythropoietin (EPO) receptor gene (as a molecular switch) and c-Mpi gene (as a signal generator)," investigators in Japan report. "Cynomolgus CD34+ cells were retrovirally transduced with or without SAG and...
Source: Cancer Weekly (2004-12-28)
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