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Pancreatic Cancer

Putative amplification target genes identified

Published in Cancer Weekly, December 28th, 2004

A large group of putative amplification target genes in pancreatic cancer have been identified.

"Comparative genomic hybridization (CGH) studies have provided a wealth of information on common copy number aberrations in pancreatic cancer, but the genes affected by these aberrations are largely unknown," oncologists in Finland explained.

"To identify putative amplification target genes in pancreatic cancer," E.H. Mahlamaki and colleagues at Tampere University "performed a parallel copy number and expression survey in 13 pancreatic cancer cell lines using a 12,232-clone cDNA microarray, providing an average resolution of 300 kb throughout the human...

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