Published in Cancer Weekly, December 28th, 2004
According to recent research published in the journal Cancer Immunology Immunotherapy, "the ability of heat shock proteins (HSPs) to increase the potency of protein- and DNA-based vaccines has been previously reported. We have constructed several plasmid-based vectors encoding chimeric proteins containing prostate-specific antigen (PSA) fused to Mycobacterium tuberculosis hsp70, M. bovis hsp65, Escherichia coli DnaK (hsp70), or human hsp70."
"Immunizing mice with these plasmids induced CD8+cytotoxic T lymphocytes (CTLs) specific to human PSA and...
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