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Breast Cancer
Selective loss of AKR1C1/2 may result in decreased progesterone catabolism
December 28th, 2004
Study results suggest that loss of expression of the AKR1C1 and AKR1C2 genes may result in decreased progesterone catabolism. "Progesterone plays an essential role in breast development and cancer formation. The local metabolism of progesterone may limit its interactions with the progesterone receptor (PR) and thereby act as a prereceptor regulator," wrote Q. Ji and colleagues. "Selective loss of AKR1C1, which encodes a 20alpha-hydroxysteroid dehydrogenase [20alpha-HSD (EC 1.1.1.149)], and AKR1C2, which encodes a 3alpha-hydroxysteroid dehydrogenase [3alpha-HSD (EC 1.1.1.52)], was found in 24 paired breast cancer samples as compared with paired normal...
Source: Cancer Weekly (2004-12-28)
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