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Breast Cancer
Stat3 upregulates MEK5 expression in breast tumor cells
December 28th, 2004
Stat3 upregulates MEK5 expression in breast tumor cells. "The constitutive activation of signal transducer and activator of transcription 3 (Stat3) is frequently detected in breast cancer cell lines but not in normal breast epithelial cells," oncologists in the United States explained. "Stat3 has been classified as an oncogene, because constitutively active Stat3 can mediate oncogenic transformation in cultured cells and tumor formation in nude mice." "Since Stat3 appears to play an important role in breast cancer, it is of interest to investigate Stat3-regulated genes and elucidate Stat3-mediated oncogenesis," noted H. Song and colleagues at...
Source: Cancer Weekly (2004-12-28)
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