Cancer Weekly
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Breast Cancer
Steroid identified as an independent prognostic marker in breast cancer
December 28th, 2004
Researchers in Japan have identified 17beta-hydroxysteroid dehydrogenase type 1 as an independent prognostic marker for breast cancer cases. "Estrogens have an important role in the development and progression of breast cancer. 17beta-Hydroxysteroid dehydrogenase type 1 (17HSD1), type 2 (17HSD2), and type 5 (17HSD5) are associated with sex steroid metabolism in normal and cancerous breast tissue," said O. Oduwole and colleagues, Oulu University. In their study, "the mRNA expressions of the 17HSD1, 17HSD2, and 17HSD5 enzymes were analyzed in 794 breast carcinoma specimens by using tissue microarrays and normal histologic sections. The results were...
Source: Cancer Weekly (2004-12-28)
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