Cancer Therapy

Scientists determine how "trump card" protein blocks DNA replication

Published in Cancer Weekly, December 28th, 2004

New research at Rice University is allowing biochemists to understand a key hierarchy of protein interactions that occurs in DNA replication, showing for the first time how a key protein "trumps" its rivals and shuts down cell division while DNA repairs take place.

The work, sponsored by the American Cancer Society, appears in the December 8, 2004, issue of the journal Structure. It could aid drug makers in designing targeted therapies that block cancer cells from multiplying.

"All cancers are marked by some form of DNA replication gone awry, so a basic understanding of DNA replication is of paramount importance to those designing...

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Source: Cancer Weekly (2004-12-28)

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