Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . January 4th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Breast Cancer - Circulating tumor cells detected in long-term cancer survivors
Cancer Therapy - Resveratrol uses a multi-step process to prevent and fight cancer
Cervical Cancer - Vaccine prevents and treats cervical cancer tumors in mice
Gastroenterology - Lymphatic vessel density and VEGF-C levels shadow pancreatic cancer growth
Prodrug - Flt3 ligand augments suicide gene therapy in a murine colon cancer model
Acute Myeloid Leukemia - Acute myeloid leukemia drug available in Japan after Nippon Shinyaku launch
Acute Myeloid Leukemia - Data: Clofarabine achieves high response rates in AML
Adverse Side Effects - Treatment for superficial bladder cancer generates hepatitis
Alzheimer Disease - Amyloidosis seen in mice expressing human amyloid peptides with Arctic mutation
Angiology - Sp1 mediates the activation of angiogenic cytokine by myristoylated Akt
Antisense Technology - XIAP protein inhibition sensitizes cancer cells to chemotherapy
Apoptosis - CXCL12/IL-2/IL-6/IL-7/IL-15 inhibits spontaneous CD45R0+ CD4+ T cell apoptosis
Awards - Harvard Health Publications lists top 10 health stories for 2004
Awards - Physician continuing education web sites receive six eHealthcare awards
Basal Cell Carcinoma - SMO antagonists potent inhibitors of UVB-induced basal cell carcinomas
Biodistribution - Dendritic poly(L-lysine) lengthens tumor retention of plasmid DNA
Bioinformatics - Researcher studies tumor genome architectures with career award
Bioterrorism - Defense contractor signs NIH agreement to evaluate virus inactivation method
Blood Cancers - Presentations focus on Genasense activity in patients with plasma cell disorders
Brain Cancer - Anticancer vaccine doubles time-to-disease progression, increases survival
Brain Cancer - HSV1716 extends the survival of patients resected for high-grade glioma
Brain Cancer - Halofuginone has antiangiogenic and antitumor effects in brain tumor models
Brain Cancer - Immunostaining for p53 can identify high-risk astrocytic tumors
Brain Tumors - Canadian tumor group actively researching promising drugs
Breast Cancer - Biomarker expression, breast cancer recurrence rates correlate, image data show
Breast Cancer - Breast cancer resistance to IR-induced apoptosis caused by independent events
Breast Cancer - COMT-L allele and COMT-LL genotype are risk factors in Turkish women
Breast Cancer - Data presented from early breast cancer treatment trial
Breast Cancer - Decision to take tamoxifen is difficult for many women at high risk of cancer
Breast Cancer - Deregulation of BTG2 expression may be important in mammary tumor development
Breast Cancer - Increasing volume requirements unlikely to improve mammogram interpretation
Breast Cancer - Little evidence found that diagnosis leads to employment discrimination
Breast Cancer - Loss of Syk expression is progressive during breast tumor development
Breast Cancer - New approach to genomic testing identifies women at low risk of recurrence
Breast Cancer - Novel quinazoline has multiple mechanisms of action in breast cancer cells
Breast Cancer - Pharmaceutical company to file new drug application for breast cancer drug
Breast Cancer - Redefining Hope and Beauty breast cancer campaign reaches out to women worldwide
Breast Cancer - Risk factors for breast cancer assessed in elderly women
Breast Cancer - SenoScan Systems installed at Indiana-based St. Vincent Breast Center
Breast Cancer - Sex hormone levels may be associated with higher risk of some types of cancer
Breast Cancer - Small variations in genes can determine risk of developing disease
Breast Cancer - Study examines impact of 2-year screening interval
Breast Cancer - Syndecan-1 ectodomain regulates matrix-dependent signaling in breast cancer cell
Breast Cancer Therapy - Tamoxifen does not prevent mobilization of body lipids
Business Update - Australia and New Zealand MammoSite distributor announced
Business Update - Distributor Oncura opts out of agreement with maker of brachytherapy device
Business Update - Investor consultant forecasts oral lung cancer drug sales to reach $103 million
Business Update - Pharma company announces agreement with SC Stormont
Cancer Detection - Proteomic pattern analysis sensitive diagnostic tool for early cancer detection
Cancer Diagnosis - False-positive screening for cancer found to be frequent and costly
Cancer Diagnosis - PET/CT imaging can help diagnose and define occult recurrent cancer
Cancer Genetics - RAB25 small GTPase determines aggressiveness of ovarian and breast cancers
Cancer Genomics and Genetics - Polymorphisms increasing risk for breast and prostate cancer reviewed
Cancer Genomics and Genetics - Tumor suppressor BRCA1 protects cells from oxidative stress
Cancer Pain Therapy - Supplemental NDA filed for sugar-free formulation of Actiq
Cancer Prevention - Cranberries may help prevent breast cancer
Cancer Prevention - Texas officials call for increase in cancer prevention, detection
Cancer Research - Clinical and preclinical results reported for Lymphoseek at conference
Cancer Research - Company announces discovery of Aurora kinase inhibitors
Cancer Research - New research shows wild blueberry compounds may fight off cancer cells
Cancer Research - Pharma company engages research group to validate Portage BioMed technology
Cancer Research - Proteomic analysis of circulating platelets can help with early cancer diagnosis
Cancer Risk - Evidence exists for link between IGF-I serum levels and cancer risk
Cancer Risk - High trihalomethane levels in Ankara water supply may increase cancer risk
Cancer Screening - $9.7 million awarded to develop molecular tools for early cancer detection
Cancer Therapy - Bioproducts companies collaborate to develop, market anticancer drug
Cancer Therapy - Boromycin may sensitize tumor cells to anti-cancer agents
Cancer Therapy - Cloned gene from sea animal may prove key in cancer drug development
Cancer Therapy - Encouraging efficacy data reported from HuMax-EGFr trial in head and neck cancer
Cancer Therapy - FDA approves Tarceva for patients with advanced non-small cell lung cancer
Cancer Therapy - Genetic target found for lymphoma treatment
Cancer Therapy - Iodine-125 InterStrand implant registered with Russian Ministry of Health
Cancer Therapy - Large cell lymphoma, Hodgkin drug study results reported at hematology meeting
Cancer Therapy - New pathway identified in angiogenesis
Cancer Therapy - Pivotal phase III trial to begin for new stem cell transplant drug candidate
Cancer Therapy - Polymeric carriers enhance Ku86 ASO delivery and augment radiotherapy
Cancer Therapy - Quinoline compounds stimulate cell differentiation in breast tumor cells
Cancer Therapy - Studies of anticancer drug in combination cancer therapies reported at meeting
Cancer Therapy - Survey suggests certain cancer patients find efficacy most important factor
Cancer Therapy - Swissmedic clears clinical trials with 1D09C3 anticancer monoclonal antibody
Cancer Treatment - CEO discusses hyperthermia therapy for cancer in The Wall Street Transcript
Cancer Treatment - RTist for AVIA introduced for use with Sceptre P3 PET/CT system
Cancer Trends - Culture, lifestyle changes may contribute to Native cancer rates
Cancer Vaccine - Antigen choice influences efficacy of antitumor dendritic cell cancer vaccine
Cancer Vaccine - Virosomes used as carrier system for cancer vaccines
Cervical Cancer - Cytologic examination of pregnant women helps find cervical neoplasia
Cervical Cancer - Two methods found effective in educating Iranian women about cervical cancer
Chronic Hepatitis C - High alpha-fetoprotein in hepatitis patients may not signal cancer
Chronic Lymphocytic Leukemia - Data: Genasense significantly increases major responses in CLL patients
Chronic Myeloid Leukemia - Study shows long-term benefits for new CML patients receiving imatinib therapy
Collaborations - Biotech firm, NCI work on development of anti-CD22 /Onconase conjugate
Collaborations - Companies form Molecular Profiling Institute to use genome project discoveries
Collaborations - Company expands R&D structure of collaboration with Roche Diagnostics
Colon Cancer - FAP-1 expression protects tumor cells from Fas-mediated apoptosis
Colon Cancer - Researchers discover naturally occurring COX-2 inhibitor
Colon Cancer Risk Factor - Commuting physical activity linked to risk of colon cancer in China
Colorectal Cancer - NOD2 3020insC alone is not sufficient for colorectal cancer predisposition
Colorectal Cancer - Genes involved in colorectal carcinogenesis identified
Colorectal Cancer - Novel oncoprotein RNF43 may be diagnostic marker
Cystic Fibrosis - Biopharma company announces orphan drug designation for PTC124
Dendritic Cell Vaccine - CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86
Dendritic Cell Vaccine - Picibanil shows promise as adjuvant for dendritic cell vaccines
Dermatology - High intensity focused ultrasound targets tumor VEGF in melanoma models
Diabetes - Biopharma company announces three-way research agreement
Diabetes - IGF-I in mammary tumorigenesis and diabetes reviewed
Diagnostic Imaging - Noninvasive images assess Kaposi sarcoma vascularity and treatment response
Diagnostics - PCR used to diagnosis P. carinii from sputum and bronchoalveolar lavage samples
Diet & Nutrition - Arginine supplementation improves medical outcome in hospitalized patients
Dioxin - Dioxin contamination levels pose health risk to infants
Drug Delivery - 188Re labeled polyethylenimine conjugates kill xenografted tumors
Drug Development - Lonidamine blocks angiogenesis by interfering with endothelial cell functions
Environmental Health - Endocrine disruptors and human health reviewed
Environmental Health - Montana had duty to warn of asbestos dangers
Esophageal Cancer - Genetic polymorphism variants not major contributors to high EC in Iran
Esophageal Cancer - HPV heterozygosity differs by geography and is associated with cancer risk
Experimental Therapy - U.S. FDA grants fast track designation for AMG 531 and AMG 706
Fertility Medicine - Case of spontaneous conception reported in young woman treated for cancer
Finance - Executives adopt Rule 10b5-1 prearranged stock sales plans
Finance - Pharma company announced private placement transaction
Fundraising - Fund for cancer patient projects at New Jersey hospital receives contributions
Fundraising - The 29th annual Hutch Holiday Gala raises more than $4.88 million
Gallbladder Tumors - Malignant gastrointestinal stromal tumor of the gallbladder diagnosed
Gastric Cancer - Effects of H. pylori VacA on tumor gene expression determined
Gastric Cancer - Gastrin and IL-1beta stimulate growth factor secretion from gastric cells
Gastric Cancer - Prognostic significance of MUC1 localization elucidated
Gastroenterology - Small and large colon tumors respond differently to CpG oligonucleotides
Gene Profiling - Several genes are differentially expressed in papillary serous ovarian cancer
Gene Therapy - PTEN gene targeting reveals radiation-induced size checkpoint in cancer cells
Genomics - Screening will facilitate definition of disease-related mutations in human mtDNA
Glioma - Clinical trial with amino acid peptide conjugate to treat glioma completed
Glioma - Histone deacetylase inhibitor 4-phenylbutyrate augments suicide gene therapy
Glioma - RFX1 gene may be epigenetically silenced in human gliomas
Gynecology - New findings predict how VEGF becomes upregulated in ovarian cancer
Gynecology - Nonviral PTEN gene transfer halts endometrial cancer cell proliferation
Gynecology - VEGF is a prognostic marker for radiation therapy-treated cervical cancer
Head & Neck Cancer - Head, neck cancer is associated with altered cytokine responsiveness
Head and Neck Cancer - Researchers use saliva to detect cancer, opening door for new diagnostic tools
Head and Neck Cancer - VEGF expression associates with recurrent lower lip squamous cell carcinoma
Healthcare Disparity - Cancer rates differ among racial and ethnic groups in California
Hematology - Glucocorticoid-targeted genes in lymphoma and leukemia cells induce apoptosis
Human Papillomavirus - Very high prevalence of HPV found in adolescent U.S. girls
Imaging Technology - Cassette-based digital mammography an alternative to screen-film mammography
Imaging Technology - Computerized mass lesion detection scheme created for DBT images
Imaging Technology - Luminance and contrast performance of LCDs for mammographic use assessed
Immunology - NKT cell subpopulations expand following cytokine stimulation
Immunotherapy - Antitumor immunotherapy kills malignant primary B cells from B-CLL patients
Information Technology - Cancer radiation firm supports study on controlling effects for cancer patients
Legal Issues - Harlan County, Kentucky, miners file suit claiming dust masks useless
Leukemia - Abstracts on elderly patients with acute myeloid leukemia presented at conference
Leukemia - Additional information from Ceplene plus Interleukin-2 trial for AML presented
Leukemia - Data show new drug successfully treats patients resistant to Gleevec
Leukemia - Doctor wins major award for pioneering research into children with leukemia
Leukemia - New drug triggers cell death in B-cell malignant and primary cancer cells
Leukemia - Peptide vaccine can produce remission in myeloid leukemia patients
Leukemia - Preliminary clinical data presented on REVLIMID for myelodysplastic syndromes
Leukemia - Prolonged efficacy for Gleevec demonstrated for newly diagnosed patients
Leukemia - Researchers find method to improve results of bone marrow transplantation
Leukemia - Study finds new treatment option for Imatinib-resistant leukemia
Leukemia - Two Genasense Injection clinical study results reported
Leukemia - Xcytrin Injectin trial results indicate clinical activity for leukemia treatment
Leukemia Therapy - Novel immunoassay facilitates alemtuzumab monitoring
Li-Fraumeni Syndrome - MIT creates new model of cancer syndrome
Liver Cancer - Alpha2 -macroglobulin marks obscure hepatocellular (pre)neoplastic lesions
Liver Cancer - Scientists hunt for "secret X" to treat liver cancer
Liver Disease - Iron chelator demonstrates efficacy but trial does not reach primary endpoint
Lung Cancer - AS1404 lung cancer trial on track
Lung Cancer - Immunotherapy vaccine trial of lung cancer treatment results reported
Lung Cancer - Lung cancer before age 50 appears to be heritable
Lung Cancer - Occludin immunostaining may have diagnostic value
Lung Cancer - Tumstatin halts the progression of human bronchopulmonary carcinomas in mice
Lung Cancer - UBE1L is a candidate target for chemoprevention
Lung Cancer - Vitamin E in plant seeds could halt prostate, lung cancer
Lung Cancer - XPD gene polymorphisms associated with increased risk of lung cancer
Lymphoma - Biopharma company announces results of MDX-060 clinical trial
Mergers & Acquisitions - Guilford to obtain exclusive worldwide ownership of AQUAVAN prodrug technology
Molecular Biology - Long-range effects are relevant for functional divergence of related galectins
Multiple Myeloma - Cyclin dependent kinase inhibitor drug shown to kill multiple myeloma cells
Multiple Myeloma - Data reported on thalidomide, melphalan, and prednisone combination
Multiple Myeloma - Multiple myeloma drug phase 1/2 survival data updated
Multiple Myeloma - Phase II trials of Aplidin begin in hematological cancers
Multiple Myeloma - Thalidomide may be effective in fighting bone marrow cancer, 2 studies show
Mutation - Mutation frequencies differ among tissue types with advancing age
Myelodysplastic Syndrome - Positive data from phase 2 trial of drug for myelodysplastic syndrome reported
Neutropenia - Study finds new method improves chemotherapy survival in mice
Non-Hodgkin Lymphoma - Cancer drug injection responses continue in subtypes of non-Hodgkin lymphoma
Non-Hodgkin Lymphoma - Chemotherapy regimen trial for non-Hodgkin lymphoma presented
Non-Hodgkin Lymphoma - Phase 1 data of talabostat in non-Hodgkin lymphoma patients presented
Non-Hodgkin Lymphoma - Study shows long-term responses in non-Hodgkin patients treated with Zevalin
Non-Hodgkin Lymphoma - Zevalin proven effective first-line therapy for low-grate follicular lymphoma
Obesity & Metabolic Syndrome - Emerging anti-obesity drugs also benefit metabolic syndrome
Oncology - Accelerated approval of oncology products in U.S. reviewed
Oncology - High-density DNA microarray dissects pancreatic carcinoma gene expression
Oncology - Lipoplex-based transfer of p75 neurotrophin receptor inhibits prostate cancer
Oncology - PTEN upregulates metastasis suppressor Drg-1 in prostate and breast cancer
Oncology - U.S. FDA approves Mucotrol
Oral Mucositis - Single dose phase 1 data on drug to prevent oral mucositis presented at ASH
Oral Squamous Cell Carcinoma - Genome-wide profiling identifies OSCC-related genes
Osteonecrosis - Doctors link common chemotherapy drug to jawbone necrosis
Ovarian Cancer - BRAF and KRAS mutations precede development of ovarian serous borderline tumors
Ovarian Cancer - Inhibin immunoassay is promising for clinical use
Ovarian Cancer - Molecular signature involving FGF2 characterized in advanced disease
Ovarian Cancer - Ovarian cancer nanobacteria study published in journal
Ovarian Cancer - Study: Women need to learn to monitor their ovarian health
Ovarian Cysts - Role of PTCH1 signaling in ovarian dermoids elucidated
Pain Medicine - Enrollment target reached for opioid-induced constipation trial
Pain Therapy - Botox reduces pain after mastectomy, study finds
Patents - U.S. patent granted for biotech company's cancer project
Personnel - Biotech company appoints chief scientific officer
Personnel - Medical imaging technology company names chief executive officer
Personnel - Philippe Archinard named CEO of French cancer-focused biopharmaceutical company
Pharmacokinetics - Platinum(IV) complex activity studied in ovarian cancer cell lines
Pipeline Update - Intercept Blood System data presented at hematology meeting
Prostate Cancer - Abbott applies for approval of prostate cancer drug
Prostate Cancer - Anti-tumor mechanisms of dutasteride clarified
Prostate Cancer - Biopharma company provides update on prostate cancer compound
Prostate Cancer - Pharma company provides update on Plenaxis commercialization
Prostate Cancer - Polyvalent prostate cancer vaccine developed
Prostate Cancer - Ritonavir enhances effects of docetaxel in androgen-independent prostate cancer
Prostate Cancer - Scientists awarded grant to study genetics of prostate cancer in Iceland
Prostate Cancer Risk Factor - Glycemic index and glycemic load associated with prostate cancer risk
Pulmonary Disease - VEGF expression in lung neuroendocrine cell lesions might be linked to fibrosis
Renal Function - Renal function in men: Cigarette smoking and cadmium and lead exposure studied
Sickle Cell Disease - New studies identify advances in sickle cell disease treatment
Sickle Cell Disease - Studies presented at conference offer promise for sickle cell disease treatment
Skin Cancer - FDA completes review of Metvix for the treatment of skin cancer
Stem Cell Research - Prop 71 founders launch California Research & Cures Coalition
Stem Cell Research - Sclerostin promotes apoptosis of osteoblastic cells
Thrombosis - Researchers used novel sensitized ENU to identify likelihood of thrombosis
Tobacco Use - British government warns of extra dangers from smuggled cigarettes
Tobacco Use - Top E.U. court upholds EU ban on Swedish snuff
Transitional Cell Carcinoma - Keratin subtyping may have prognostic value in urinary tract TCCs
Tumor Suppression - PPARgamma ligands help the thrombospondin peptide ABT510 fight tumor growth
Urology - Angiogenic protein levels drift in urinary bladder transitional cell carcinomas
Urology - Gene expression profiles are altered in murine bladder cancer
Vaccine Development - Bovine aortic endothelial cell immunization stalls glioma neovascularization
Virology - Efforts to control adenoviral cancer gene therapy mitigate adverse effects
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