Cancer Genomics and Genetics
Tumor suppressor BRCA1 protects cells from oxidative stress
Published in Cancer Weekly, January 4th, 2005
"Mutations of the breast cancer susceptibility gene 1 (BRCA1)" confer an "increased risk for breast, ovarian, and prostate cancers," researchers in the United States explained.
"To investigate the function of the BRCA1 gene," I. Bae and colleagues at Georgetown University "performed DNA microarray and confirmatory reverse transcription-PCR analyses to identify BRCA1-regulated gene expression changes."
BRCA1 "upregulates the expression of multiple genes involved in the cytoprotective antioxidant response, including glutathione S-transferases,...
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Source: Cancer Weekly (2005-01-04)
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