Prodrug
Flt3 ligand augments suicide gene therapy in a murine colon cancer model
Published in Cancer Weekly, January 4th, 2005
"In prodrug-activated ('suicide') gene therapy, tumor cells are transfected with the gene for an enzyme that converts an inactive prodrug, such as ganciclovir (GCV), to a toxic compound. Transfected cells are killed on administration of GCV, as also are untransfected 'bystander' cells. The ability of the dendritic cell stimulatory cytokine Flt3 ligand (Flt3-L) to modulate prodrug-activated gene therapy has been investigated," researchers in England report.
"Transfectants of the murine colon carcinoma MC26 were generated expressing soluble (FLS) and membrane-bound forms of...
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Source: Cancer Weekly (2005-01-04)
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