Cancer Therapy
Polymeric carriers enhance Ku86 ASO delivery and augment radiotherapy
Published in Cancer Weekly, January 4th, 2005
According to recent research from Canada, "in an effort to improve the efficacy of antisense delivery, we evaluated polyethyleneimine (PEI, 2 kDa) alone or grafted with nonionic amphiphilic block copolymer pluronic (P85) as a carrier for Ku86 antisense oligonucleotide (ASO) delivery."
"Ku86 is an abundant nuclear protein that plays an important role in nonhomologous DNA end joining and has implications in tumorigenesis and acquired drug resistance. Transfection of adherent and suspension cell lines with Ku86 ASOs complexed with P85-g-PEI (2 kDa) conjugates was associated with a...
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Source: Cancer Weekly (2005-01-04)
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