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Prostate Cancer Therapy

Antibody-chemotherapeutic conjugate designed for prostate cancer therapy

Published in Cancer Weekly, January 11th, 2005

Researchers have designed a prostate-specific membrane antigen-targeted monoclonal antibody-chemotherapeutic conjugate designed for the treatment of prostate cancer.

According to recent research from the United States, "MLN2704 is an antibody-chemotherapeutic conjugate designed to target prostate-specific membrane antigen (PSMA). PSMA is a transmembrane receptor whose expression is largely restricted to prostatic epithelium and prostate cancer cells with its expression level increasing during the progression of malignancy. MLN2704 consists of a de-immunized, monoclonal antibody that is specific for PSMA conjugated to drug may-tansinoid 1 (DM1), a...

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