Cancer Therapy

Riddelliine mutagenicity different in liver endothelial and parenchymal cells

Published in Cancer Weekly, January 18th, 2005

Researchers report differential mutagenicity of riddelliine in liver endothelial and parenchymal cells of transgenic big blue rats.

"Riddelliine is a naturally occurring pyrrolizidine alkaloid that induces liver hemangiosarcomas in rats and mice. We previously reported higher levels of DNA adducts in liver endothelial cells than in liver parenchymal cells of riddellime-treated mice and rats, suggesting that the tumor specificity is due to higher levels of DNA damage in the cells that form hemangosarcomas. In the present study, we evaluated the cell-specificity of riddelliine mutagenicity in rat liver. Female transgenic Big Blue rats were treated by gavage with 0.3 mg...

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Source: Cancer Weekly (2005-01-18)

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