Developmental Biology

"Atlas" of key brain genes could speed research on cancer, neurological diseases

Published in Cancer Weekly, January 18th, 2005

Researchers at Dana-Farber Cancer Institute have compiled the first atlas showing the locations of crucial gene regulators, or switches that determine how different parts of the brain develop - and, in some cases, develop abnormally or malfunction.

The scientists say the map will accelerate research on brain tumors and neurological diseases that result from mutations in these switch genes - called "transcription factors." When these genes are altered, the genes they control can go awry, causing abnormalities in the development or function of nerves and related structures.

Although the gene regulators were pinpointed using mouse brains, the map...

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Source: Cancer Weekly (2005-01-18)

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