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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . January 25th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Breast Cancer - Statins may have anticarcinogenic effects in older women

Cancer Genetics - Recent findings in cancer genetics provide new insights

Cystectomy - Robotic radical cystectomy for managing bladder cancer reviewed

Oncology - Ultrasonography accurately detects lymph-node invasion

Skin Cancer - Melanocortin 1 receptor variants affect skin cancer susceptibility

Acute Lymphocytic Leukemia - Unrelated cord blood transplantation is an option for children with ALL

Acute Myelogenous Leukemia - Clinical outcome not affected in pediatric AML patients with PTPN11 mutations

Acute Myeloid Leukemia - 57.9% of elderly acute myeloid leukemia study patients respond to chemotherapy

Adolescent Health - Study reveals high infection rate in teens for virus linked to cervical cancer

Adult T-Cell Leukemia - Adult T-cell leukemia cells down-regulate CD26 antigens via epigenetic machinery

Air Pollution - Several hazardous air pollutants exceed cancer risk level in Portland

Allergy and Immunology - Thymalfasin augments the immune system's response to disease

Alzheimer Disease - New research in the area of Alzheimer disease detailed

Anemia - Anemia prevalent in cancer patients, European Cancer Anaemia Survey shows

Angiology - Vascular smooth muscle viability is pertinent to tumor biology

Antioxidants - Oral antioxidants have mixed effects on UV-induced skin damage

Apoptosis - Tumor necrosis factor-alpha induces apoptosis in adrenocortical cells

Astrocytoma - Chromosomal aberrations identified in diffuse astrocytomas

Biomarkers - Biomarkers valuable for risk assessment in molecular epidemiology of cancer

Bladder Cancer - No association between inorganic arsenic concentration and bladder cancer risk

Breast Cancer - Adenosine is a breast carcinoma cell mitogen

Breast Cancer - Adjuvant HT or chemotherapy choice should be offered to women with ER+ tumors

Breast Cancer - Angiogenic profiles of breast carcinomas expose leukocyte penetration

Breast Cancer - Anti-aromatase coumarin derivative characterized

Breast Cancer - Breast cancer may be uniquely sensitive to inhibitors of PI3K pathway

Breast Cancer - Chemotherapy and long-term outcome compared between lobular and ductal disease

Breast Cancer - Drugs induce superinvasive phenotype in breast cancer cells

Breast Cancer - Insulin receptor substrate is involved in mammary tumor metastasis

Breast Cancer - Mammograms probably don't cause much more biological damage than hard X-rays

Breast Cancer - Mammography archived at Univ. of Pennsylvania Health System

Breast Cancer - More frequent mammography for women on HRT suggested

Breast Cancer - New findings in breast cancer described

Breast Cancer - New findings in the area of breast cancer described

Breast Cancer - New research in the area of breast cancer detailed

Breast Cancer - Pharma company updates breast cancer research results from 2004 symposium

Breast Cancer - RT-PCR detects disseminated epithelial cells in BM of breast cancer patients

Breast Cancer - Radiotherapy, susceptibility may increase risk after childhood Hodgkin disease

Breast Cancer - Reports describe recent advances in breast cancer research

Breast Cancer - Researchers call for new approach to clinical trials in postgenomic era

Breast Cancer - Studies describe new findings in breast cancer research

Breast Cancer - U.S. FDA clears use of automated scanning system for PathVysion DNA

Business Update - Generic pharmaceutical company announces filing of ANDA with U.S. FDA

Business Update - GeoPharma shares launch strategy for Mucotrol

Business Update - Subsidiary granted marketing rights for Neovastat

Cadmium Exposure - Increased cadmium exposure may influence occurrence of disease

Cancer Genetics - Loss of BRCA1 function associated with sensitivity to DNA-damaging chemotherapy

Cancer Risk - Elevated glucose levels and diabetes associated with risk for cancer

Cancer Surgery - Complications of free flap head and neck reconstruction reviewed

Cancer Survival - Reduced health care access and ability to pay decrease cancer survival

Cancer Therapy - Additional information provided to U.S. FTC for melanoma treatment

Cancer Therapy - Angiogenesis inhibitors antagonize lymphoma proliferation

Cancer Therapy - Breast cancer patients boost quality of life with vaginal moisturizer

Cancer Therapy - Brochures help cancer patients make informed treatment decisions

Cancer Therapy - Cancer coalition donates medical goods

Cancer Therapy - Clolar wins FDA approval for common pediatric leukemia

Cancer Therapy - Data on successful treatments for lymphoma with few side effects presented

Cancer Therapy - Free makeovers at Alabama hospital boost spirits of cancer patients

Cancer Therapy - IND filed with U.S. FDA for AP5346

Cancer Therapy - Imaging study of dogs offers insight into 9/11 resulting cancers

Cancer Therapy - New treatment for cancer of the larynx at available at medical center

Cancer Therapy - Protein arginine methyltransferase complexes regulate tumor suppressor genes

Cancer Therapy - Quinolones enhance antitumor activity of ultrasonic irradiation

Cancer Therapy - Research in cancer therapy provides new insights

Cancer Therapy - Researchers detail new studies and findings in the area of cancer therapy

Cancer Therapy - Researchers publish new studies and findings in the area of cancer therapy

Cancer Therapy - Residual tumor cells are a barrier to targeted cancer therapeutics

Cancer Therapy - Study examines target for blocking new lymphatic growth

Cancer Therapy - Trial: IRESSA failed to significantly prolong survival in comparison to placebo

Cancer Therapy - Tumor cells resistant to hemiasterlin analogue characterized

Cancer Vaccines - Biopharmaceutical company announces survival data of trial with cancer vaccine

Cancer Vaccines - Findings advance knowledge in cancer vaccines research

Cancer Vaccines - Reports add new data to cancer vaccines research

Cancer Vaccines - Researchers' findings advance cancer vaccines research

Cancer Vaccines - Studies add new findings to cancer vaccines body of knowledge

Cancer Vaccines - Studies advance knowledge in cancer vaccines research

Carcinogenesis - Reports describe recent advances in carcinogenesis research

Cell Biology - Researchers discover how serum factors prevent TRAIL-induced apoptosis

Cell Biology - Researchers tease out one critical role of tumor-suppressor gene

Cell Biology - Study of hypoxia and new gene reveals early-stage action of p53 gene

Cell Biology - VEGF increases the availability of channels used for paracellular transport

Cervical Cancer - Exposure to secondhand smoke increases risk of developing cervical tumors

Cervical Cancer - Recent studies add new data to cervical cancer research

Cervical Cancer - Reports advance knowledge in cervical cancer research

Clinical Trails - Phase II trial of HyCAMPTM initiated for colorectal cancer

Clinical Trials - Company provides update on cancer and HIV clinical-development programs

Clinical Trials - Results of autoimmune therapy in healthy volunteers study released

Clinical Trials - Synthetic antibodies manufacturer announces phase 1 trial

Collaborations - Alliance formed for Canvaxin for melanoma

Collaborations - Discovery program launched to combine antibody technologies

Collaborations - GPC Biotech announces achievement of milestones totaling $1.2M

Colon Cancer - Breakthrough cancer treatment Avastin approved in Switzerland

Colon Cancer - CHOP regulates ER stress-induced apoptosis by enhancing DR5 expression

Colon Cancer - Integrated therapies show promise for treating colorectal cancer

Colon Cancer - Long-term consumption of red and processed meat linked with cancer risk

Colon Cancer - System detects colon polyps in colons previously obscured by fluid

Colorectal Cancer - APAF-1 gene dysfunction from allelic imbalance increases with tumor progression

Colorectal Cancer - Colorectal cancer detected by quantitative fluorescence of stool DNA

Colorectal Cancer - Data advance knowledge in colorectal cancer research

Colorectal Cancer - HNPCC predictive genetic testing does not cause adverse psychological outcomes

Colorectal Cancer - High dietary intake of magnesium may help reduce women's risk

Complementary & Alternative Medicine - Green tea flavonoid may lower the invasive potential of prostate cancer

Cystic Fibrosis - Biopharma company announces phase 1 study for PTC124

Dermatology - Researchers' work adds to dermatology body of knowledge

Dermatology - Semaphorin 3F prohibits melanoma metastasis

Diagnostics - Catholic University in Rome receives CTLM system

Diagnostics - Fluorescent ligation detection assay identifies leukemia translocations

Diet & Nutrition - New ebook discusses alternative therapy to reverse chronic disease

Diet and Nutrition - Dietary fiber from barley possesses anti-mutagenic activity

Diet and Nutrition - Mechanism of olive oil's protective effect against breast cancer determined

Diet and Nutrition - Study finds eating fruits, vegetables doesn't reduce breast cancer risk

Drug Development -  Emblica officinalis extract reduces DMBA genotoxicity in mice

Drug Development - AstraZeneca withdraws application to market lung cancer drug

Drug Development - Companies enter partnership to commercialize functional human protein arrays

Drug Development - Investigational new drug application submitted for cancer candidate

Drug Development - Medicinal and pharmaceutical uses of seaweed natural products reviewed

Drug Development - Novel docetaxel analogues with high tubulin activity synthesized

Drug Resistance - ABC transporters have multiple functions in drug resistance

Drug Resistance - Curcumin I most effective multidrug resistance modulator among curcuminoids

Embryonal Brain Tumor - Notch1 and Notch2 can have opposite effects on single tumor type growth

Endocrinology - Affect of exogenous progestagens on the human breast remains controversial

Environmental Health - Component of plastic stimulates growth of certain prostate cancer cells

Epidemiology - Molecular studies predict higher rates of liver cancer in the United States

Epidermal Growth Factor - Esophageal keratinocyte migration studied, role of signaling pathway revealed

Estrogen - Estradiol-induced induction does not require direct MAPK/ERK activation

Finance - Cancer-focused biopharmaceutical company files registration for proposed IPO

Finance - Cancer/inflammation-focused biopharma announces $14M private placement

Finance - Cell-based company executive adopts Rule 10b5-1 prearranged stock sales plan

Finance - Company announces closing of $60M private placement of common stock

Finance - Company's stock delisted, per its demand, from Berlin-Bremen stock exchange

Finance - DNA-focused company announces third quarter 2004 financial results

Finance - Drug discovery company announced private placement

Finance - Four teams awarded inaugural translational cancer research grants

Finance - Genetics-focused biopharmaceutical company reports Q3 2004 financial results

Finance - Medical imaging software company announces record revenue in third quarter 2004

Finance - Nevada Cancer Institute gets $25 million "challenge grant"

Finance - Oncology-focused medical device company announces third quarter 2004 results

Finance - Pharma company provides financial update

Finance - Protein-focused biopharmaceutical company reports Q3 2004 financial results

Gastric Cancer Diagnostics - LOH genotyping may be independent prognostic indicator in gastric carcinoma

Gastroenterology - Findings describe new data in gastroenterology research

Gastroenterology - Interferon-alpha and antisense K-ras RNA suppress pancreatic cancer cell growth

Gastrointestinal Stromal Tumor - Double-balloon enteroscopy aids in diagnosis of gastrointestinal stromal tumor

Gene Transfer - Nucleotides targeting anti-apoptosis protein bind to erythroleukemia cells

Genomics - New research in the area of genomics detailed

Genomics and Genetics - Effects of tetrodotoxin exposure on human glial cells clarified

Genomics and Genetics - Growth arrest pathway genes also regulate metabolism and mitochondria

Glioma - Diffusion-weighted imaging values highlight brain tumor invasion

Graft-Versus-Tumor Effect - Graft-versus-tumor effect following ASCT generated against solid tumors

Grants - Nevada Cancer institute receives $25 million matching-funds grant

Grants - Univ. of Oklahoma Health Center sees grant increases

Gynecology - Doppler flow studies don't differentiate leiomyomas from leiomyosarcomas

Gynecology - SU5416 controls enzyme signals to block ovarian cancer angiogenesis

Hair Studies - Forkhead gene Foxe1 required for hair follicle morphogenesis

Health Education - Cancer support talk radio show now heard via Internet and satellite

Health Promotion - Medicare will help beneficiaries quit smoking

Healthcare Coverage - GI societies call for insurance coverage for colorectal cancer screening

Helicobacter pylori -  Helicobacter pylori may play role in conjunctival MALT lymphoma

Hematology - Proangiogenic protein protects multiple myeloma from apoptosis

Hematopoietic Malignancy - Blocking constitutive STAT5 activation may treat hematopoietic malignancies

Hepatoblastoma - Single-agent cyclophosphamide ineffectual in refractory, relapsing HB patients

Hepatocellular Carcinoma - Risk of delirium after liver resection for hepatocellular carcinoma studied

Immunology - Drm/Gremlin and Dan interact with Slits and inhibit monocyte chemotaxis

Information Technology - Voluntary health organizations, publishers announce information initiative

Kaposi Sarcoma-Associated Herpes Virus - Small GTPase Rac1 links KSHV vGPCR to cytokine secretion and paracrine neoplasia

Kaposi Sarcoma-Associated Herpesvirus - Fetal mesencyhmal stem cells susceptible to KSHV infection

Kaposi Sarcoma-Associated Herpesvirus - Findings describe new data in kaposi sarcoma-associated herpesvirus research

Legal Issues - U.S. court upholds patent infringement suit against generic antibiotic maker

Leukemia - Chemotherapy drug combination shows promise for leukemia treatment

Leukemia - Girl in remission after leukemia diagnosis, twin sister's organ donation

Leukemia - Higher BMI associated with increased risk of AML, but not CLL in older women

Leukemia - Isolated extramedullary relapse appears common after Chemo-DLI

Liver Cancer - Genes with prognostic value in hepatocellular carcinoma identified

Liver Cancer - Quercetin induces selective growth inhibition/apoptosis in hepatic tumor cells

Lung Cancer - PI3-kinase pathway involved in early progression

Malignant Mesothelioma - MM cells expressing Slug have increased resistance to chemotherapeutic agents

Melanoma - Order of treatment critical for avoiding toxicity

Meningiomas - Galectin-3-binding sites, S100B may affect atypical meningioma aggressiveness

Metastases - Scientists study how cancer cells get out of control

Metastatic Melanoma - Taxanes may be treatment option for metastatic melanoma

Molecular Diagnostics - Multiplexed RT-PCR valuable for high throughput screening applications

Multiple Myeloma - Cancer drug study results indicate potential for treating multiple myeloma

Mutagenesis - Electrochemiluminescence assay shows point mutations in cancer samples

Nanotechnology - New protein holds promise for use in medicine and nanoscience

Neoplasia - Bcl-2-related genes important in tumor initiation/progression/therapy response

Neovascularization - Mast cell-derived angiopoietin-1 promotes plasmacytoma growth

Neurofibromatosis - Brain tumor study reveals why treatment efforts fail in genetic disorder

Neuroscience - Recent findings in neuroscience described

Neuroscience - The Wilms tumor gene is overexpressed in primary astrocytic tumors

Non-Hodgkin Lymphoma - Pesticide exposure may be associated with increased risk of NHL among women

Non-Small Cell Lung Cancer - Cancer vaccine trial data updated

Oncogenesis - Hepatitis C virus transfection produces liver cell growth and tumorigenesis

Oncogenesis - Research in oncogenesis provides new insights

Oncology - Chromosome changes are prognostic indicators in multiple myeloma patients

Oncology - Integrin signals link survival elements in recurrent prostate cancer

Oncology - Interleukin-10 may enable liver cancer to evade immune response mechanisms

Oncology - Paclitaxel halts angiogenesis at similar rates despite dissimilar scheduling

Oncology - Putative HOX11 target genes identified

Oncology - Researchers provide details of new studies and findings in the area of oncology

Oncology - SPRY2 activity in presence of wild-type and mutant BRAF clarified

Oncology - Studies advance knowledge in oncology research

Oncology - T cell type cancer predominates in Korean primary hepatic lymphoma cases

Oncology - Thrombin is involved in tumor invasion

Oral Cancer - Dietary zinc affects cox-2 expression and esophageal and tongue carcinogenesis

Oral Cancer - Finding abnormal p16 methylation pattern may aid in early oral cancer detection

Ovarian Cancer - Assay combination has potential to double response rate to chemotherapy

Ovarian Cancer - Cell lines analyzed using array-based comparative genomic hybridization

Ovarian Cancer - Company enrolls, initiates reviews phases of clinical trials for cancer drug

Ovarian Cancer - Progesterone signaling appears to influence disease risk

Pain Medicine - Outcomes of anesthetic-delivery device following mastectomy reported

Patents - Biotech company acquires gene encoding patent from Akademikliniken AB of Sweden

Patents - Diagnostics products developer announces patent issuance

Pediatric Oncology - Auto company retailers help raise $1 million for pediatric cancer research

Personnel - Biopharma company names new board member

Personnel - Biotechnology company appoints director of regulatory affairs

Personnel - California controller names Philip Pizzo, MD, to stem-cell oversight committee

Personnel - Health minister, battling cancer, says he likely will resign

Preventive Medicine - 20M smokers resolve to quit in 2005 again

Product Licensing - CAD, 3-D imaging companies announce licensing agreement for computed tomography

Product Licensing - Company inks licensing agreement in Mexico for Decapeptyl Depot, Decapeptyl LA

Product Licensing - License agreement for glioblastoma multiforme treatment candidate signed

Prostate Cancer - Calcitriol induces prostate-derived factor expression in tumor cells

Prostate Cancer - Company reaches milestone in development of prostate cancer classification test

Prostate Cancer - Experience with Vattikuti Institute prostatectomy reported

Prostate Cancer - Modified yeast assay improves detection of p53 abnormalities in prostate cancer

Prostate Cancer - More precise radiation therapy lets patients avoid erectile dysfunction

Prostate Cancer - Researchers report on case of spinal cord metastasis from prostate cancer

Prostate Cancer - Retinol, lycopene not significantly related to prostate cancer risk in study

Protein Methylation - Stable HeLa cell protein methylation produced by adenosine dialdehyde treatment

Proteomics - Properties of mutant alpha-tropomyosin were compared to wild protein

Proteomics - Zinc-finger protein TIS11b destabilizes angiogenic cytokine

Radiotherapy - Risk estimation made of hereditary effects due to radiation therapy

Renal Cancer - Angiogenesis inhibitors help patients with advanced renal cell carcinoma

Renal Cell Carcinoma - Use of retinoids in the treatment of renal cell carcinoma may be a futile effort

Rounded Atelectasis - Researchers report on asbestos-exposed worker with rounded atelectasis

Soft Tissue Sarcoma - Licensed oncology drug for soft tissue sarcoma in clinical trials at Wayne State

Spinal Cord Compression - Researchers report on vertebroplasty for tumor-related spinal cord compression

State Medicaid - Iowa Governor says raise cigarette tax to help fund Medicaid

Stem Cell Research - Nucleostemin plays important role in self-renewal of cancer cells

Stem Cell Transplantation - GVHD still a major limitation to successful hematopoietic SCT

Stem Cell Transplantation - HD radiochemotherapy followed by ASCT improves survival in follicular lymphoma

Stem Cell Transplantation - Non-myeloablative SCT safer than myeloablation for autoimmune diseases

Stress Induction - Multiple stress signals induce p73 beta accumulation

Surgical Technology - Imaging center announces noninvasive procedure for uterine fibroids

Surgical Technology - Report published examining forecast in eight major surgical specialties

Tobacco Use - American Lung Association gives Oregon poor grades

Transitional Cell Carcinoma - Researchers report on transitional cell carcinoma in renal transplant recipients

Tumor Suppression - Cdk inhibitor p21 has tumor suppressor function in colon

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