Susan Hasty, Publisher
Table of Contents . . . January 25th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Breast Cancer - Statins may have anticarcinogenic effects in older women
Cancer Genetics - Recent findings in cancer genetics provide new insights
Cystectomy - Robotic radical cystectomy for managing bladder cancer reviewed
Oncology - Ultrasonography accurately detects lymph-node invasion
Skin Cancer - Melanocortin 1 receptor variants affect skin cancer susceptibility
Acute Lymphocytic Leukemia - Unrelated cord blood transplantation is an option for children with ALL
Acute Myelogenous Leukemia - Clinical outcome not affected in pediatric AML patients with PTPN11 mutations
Acute Myeloid Leukemia - 57.9% of elderly acute myeloid leukemia study patients respond to chemotherapy
Adolescent Health - Study reveals high infection rate in teens for virus linked to cervical cancer
Adult T-Cell Leukemia - Adult T-cell leukemia cells down-regulate CD26 antigens via epigenetic machinery
Air Pollution - Several hazardous air pollutants exceed cancer risk level in Portland
Allergy and Immunology - Thymalfasin augments the immune system's response to disease
Alzheimer Disease - New research in the area of Alzheimer disease detailed
Anemia - Anemia prevalent in cancer patients, European Cancer Anaemia Survey shows
Angiology - Vascular smooth muscle viability is pertinent to tumor biology
Antioxidants - Oral antioxidants have mixed effects on UV-induced skin damage
Apoptosis - Tumor necrosis factor-alpha induces apoptosis in adrenocortical cells
Astrocytoma - Chromosomal aberrations identified in diffuse astrocytomas
Biomarkers - Biomarkers valuable for risk assessment in molecular epidemiology of cancer
Bladder Cancer - No association between inorganic arsenic concentration and bladder cancer risk
Breast Cancer - Adenosine is a breast carcinoma cell mitogen
Breast Cancer - Adjuvant HT or chemotherapy choice should be offered to women with ER+ tumors
Breast Cancer - Angiogenic profiles of breast carcinomas expose leukocyte penetration
Breast Cancer - Anti-aromatase coumarin derivative characterized
Breast Cancer - Breast cancer may be uniquely sensitive to inhibitors of PI3K pathway
Breast Cancer - Chemotherapy and long-term outcome compared between lobular and ductal disease
Breast Cancer - Drugs induce superinvasive phenotype in breast cancer cells
Breast Cancer - Insulin receptor substrate is involved in mammary tumor metastasis
Breast Cancer - Mammograms probably don't cause much more biological damage than hard X-rays
Breast Cancer - Mammography archived at Univ. of Pennsylvania Health System
Breast Cancer - More frequent mammography for women on HRT suggested
Breast Cancer - New findings in breast cancer described
Breast Cancer - New findings in the area of breast cancer described
Breast Cancer - New research in the area of breast cancer detailed
Breast Cancer - Pharma company updates breast cancer research results from 2004 symposium
Breast Cancer - RT-PCR detects disseminated epithelial cells in BM of breast cancer patients
Breast Cancer - Radiotherapy, susceptibility may increase risk after childhood Hodgkin disease
Breast Cancer - Reports describe recent advances in breast cancer research
Breast Cancer - Researchers call for new approach to clinical trials in postgenomic era
Breast Cancer - Studies describe new findings in breast cancer research
Breast Cancer - U.S. FDA clears use of automated scanning system for PathVysion DNA
Business Update - Generic pharmaceutical company announces filing of ANDA with U.S. FDA
Business Update - GeoPharma shares launch strategy for Mucotrol
Business Update - Subsidiary granted marketing rights for Neovastat
Cadmium Exposure - Increased cadmium exposure may influence occurrence of disease
Cancer Genetics - Loss of BRCA1 function associated with sensitivity to DNA-damaging chemotherapy
Cancer Risk - Elevated glucose levels and diabetes associated with risk for cancer
Cancer Surgery - Complications of free flap head and neck reconstruction reviewed
Cancer Survival - Reduced health care access and ability to pay decrease cancer survival
Cancer Therapy - Additional information provided to U.S. FTC for melanoma treatment
Cancer Therapy - Angiogenesis inhibitors antagonize lymphoma proliferation
Cancer Therapy - Breast cancer patients boost quality of life with vaginal moisturizer
Cancer Therapy - Brochures help cancer patients make informed treatment decisions
Cancer Therapy - Cancer coalition donates medical goods
Cancer Therapy - Clolar wins FDA approval for common pediatric leukemia
Cancer Therapy - Data on successful treatments for lymphoma with few side effects presented
Cancer Therapy - Free makeovers at Alabama hospital boost spirits of cancer patients
Cancer Therapy - IND filed with U.S. FDA for AP5346
Cancer Therapy - Imaging study of dogs offers insight into 9/11 resulting cancers
Cancer Therapy - New treatment for cancer of the larynx at available at medical center
Cancer Therapy - Protein arginine methyltransferase complexes regulate tumor suppressor genes
Cancer Therapy - Quinolones enhance antitumor activity of ultrasonic irradiation
Cancer Therapy - Research in cancer therapy provides new insights
Cancer Therapy - Researchers detail new studies and findings in the area of cancer therapy
Cancer Therapy - Researchers publish new studies and findings in the area of cancer therapy
Cancer Therapy - Residual tumor cells are a barrier to targeted cancer therapeutics
Cancer Therapy - Study examines target for blocking new lymphatic growth
Cancer Therapy - Trial: IRESSA failed to significantly prolong survival in comparison to placebo
Cancer Therapy - Tumor cells resistant to hemiasterlin analogue characterized
Cancer Vaccines - Biopharmaceutical company announces survival data of trial with cancer vaccine
Cancer Vaccines - Findings advance knowledge in cancer vaccines research
Cancer Vaccines - Reports add new data to cancer vaccines research
Cancer Vaccines - Researchers' findings advance cancer vaccines research
Cancer Vaccines - Studies add new findings to cancer vaccines body of knowledge
Cancer Vaccines - Studies advance knowledge in cancer vaccines research
Carcinogenesis - Reports describe recent advances in carcinogenesis research
Cell Biology - Researchers discover how serum factors prevent TRAIL-induced apoptosis
Cell Biology - Researchers tease out one critical role of tumor-suppressor gene
Cell Biology - Study of hypoxia and new gene reveals early-stage action of p53 gene
Cell Biology - VEGF increases the availability of channels used for paracellular transport
Cervical Cancer - Exposure to secondhand smoke increases risk of developing cervical tumors
Cervical Cancer - Recent studies add new data to cervical cancer research
Cervical Cancer - Reports advance knowledge in cervical cancer research
Clinical Trails - Phase II trial of HyCAMPTM initiated for colorectal cancer
Clinical Trials - Company provides update on cancer and HIV clinical-development programs
Clinical Trials - Results of autoimmune therapy in healthy volunteers study released
Clinical Trials - Synthetic antibodies manufacturer announces phase 1 trial
Collaborations - Alliance formed for Canvaxin for melanoma
Collaborations - Discovery program launched to combine antibody technologies
Collaborations - GPC Biotech announces achievement of milestones totaling $1.2M
Colon Cancer - Breakthrough cancer treatment Avastin approved in Switzerland
Colon Cancer - CHOP regulates ER stress-induced apoptosis by enhancing DR5 expression
Colon Cancer - Integrated therapies show promise for treating colorectal cancer
Colon Cancer - Long-term consumption of red and processed meat linked with cancer risk
Colon Cancer - System detects colon polyps in colons previously obscured by fluid
Colorectal Cancer - APAF-1 gene dysfunction from allelic imbalance increases with tumor progression
Colorectal Cancer - Colorectal cancer detected by quantitative fluorescence of stool DNA
Colorectal Cancer - Data advance knowledge in colorectal cancer research
Colorectal Cancer - HNPCC predictive genetic testing does not cause adverse psychological outcomes
Colorectal Cancer - High dietary intake of magnesium may help reduce women's risk
Complementary & Alternative Medicine - Green tea flavonoid may lower the invasive potential of prostate cancer
Cystic Fibrosis - Biopharma company announces phase 1 study for PTC124
Dermatology - Researchers' work adds to dermatology body of knowledge
Dermatology - Semaphorin 3F prohibits melanoma metastasis
Diagnostics - Catholic University in Rome receives CTLM system
Diagnostics - Fluorescent ligation detection assay identifies leukemia translocations
Diet & Nutrition - New ebook discusses alternative therapy to reverse chronic disease
Diet and Nutrition - Dietary fiber from barley possesses anti-mutagenic activity
Diet and Nutrition - Mechanism of olive oil's protective effect against breast cancer determined
Diet and Nutrition - Study finds eating fruits, vegetables doesn't reduce breast cancer risk
Drug Development - Emblica officinalis extract reduces DMBA genotoxicity in mice
Drug Development - AstraZeneca withdraws application to market lung cancer drug
Drug Development - Companies enter partnership to commercialize functional human protein arrays
Drug Development - Investigational new drug application submitted for cancer candidate
Drug Development - Medicinal and pharmaceutical uses of seaweed natural products reviewed
Drug Development - Novel docetaxel analogues with high tubulin activity synthesized
Drug Resistance - ABC transporters have multiple functions in drug resistance
Drug Resistance - Curcumin I most effective multidrug resistance modulator among curcuminoids
Embryonal Brain Tumor - Notch1 and Notch2 can have opposite effects on single tumor type growth
Endocrinology - Affect of exogenous progestagens on the human breast remains controversial
Environmental Health - Component of plastic stimulates growth of certain prostate cancer cells
Epidemiology - Molecular studies predict higher rates of liver cancer in the United States
Epidermal Growth Factor - Esophageal keratinocyte migration studied, role of signaling pathway revealed
Estrogen - Estradiol-induced induction does not require direct MAPK/ERK activation
Finance - Cancer-focused biopharmaceutical company files registration for proposed IPO
Finance - Cancer/inflammation-focused biopharma announces $14M private placement
Finance - Cell-based company executive adopts Rule 10b5-1 prearranged stock sales plan
Finance - Company announces closing of $60M private placement of common stock
Finance - Company's stock delisted, per its demand, from Berlin-Bremen stock exchange
Finance - DNA-focused company announces third quarter 2004 financial results
Finance - Drug discovery company announced private placement
Finance - Four teams awarded inaugural translational cancer research grants
Finance - Genetics-focused biopharmaceutical company reports Q3 2004 financial results
Finance - Medical imaging software company announces record revenue in third quarter 2004
Finance - Nevada Cancer Institute gets $25 million "challenge grant"
Finance - Oncology-focused medical device company announces third quarter 2004 results
Finance - Pharma company provides financial update
Finance - Protein-focused biopharmaceutical company reports Q3 2004 financial results
Gastric Cancer Diagnostics - LOH genotyping may be independent prognostic indicator in gastric carcinoma
Gastroenterology - Findings describe new data in gastroenterology research
Gastroenterology - Interferon-alpha and antisense K-ras RNA suppress pancreatic cancer cell growth
Gastrointestinal Stromal Tumor - Double-balloon enteroscopy aids in diagnosis of gastrointestinal stromal tumor
Gene Transfer - Nucleotides targeting anti-apoptosis protein bind to erythroleukemia cells
Genomics - New research in the area of genomics detailed
Genomics and Genetics - Effects of tetrodotoxin exposure on human glial cells clarified
Genomics and Genetics - Growth arrest pathway genes also regulate metabolism and mitochondria
Glioma - Diffusion-weighted imaging values highlight brain tumor invasion
Graft-Versus-Tumor Effect - Graft-versus-tumor effect following ASCT generated against solid tumors
Grants - Nevada Cancer institute receives $25 million matching-funds grant
Grants - Univ. of Oklahoma Health Center sees grant increases
Gynecology - Doppler flow studies don't differentiate leiomyomas from leiomyosarcomas
Gynecology - SU5416 controls enzyme signals to block ovarian cancer angiogenesis
Hair Studies - Forkhead gene Foxe1 required for hair follicle morphogenesis
Health Education - Cancer support talk radio show now heard via Internet and satellite
Health Promotion - Medicare will help beneficiaries quit smoking
Healthcare Coverage - GI societies call for insurance coverage for colorectal cancer screening
Helicobacter pylori - Helicobacter pylori may play role in conjunctival MALT lymphoma
Hematology - Proangiogenic protein protects multiple myeloma from apoptosis
Hematopoietic Malignancy - Blocking constitutive STAT5 activation may treat hematopoietic malignancies
Hepatoblastoma - Single-agent cyclophosphamide ineffectual in refractory, relapsing HB patients
Hepatocellular Carcinoma - Risk of delirium after liver resection for hepatocellular carcinoma studied
Immunology - Drm/Gremlin and Dan interact with Slits and inhibit monocyte chemotaxis
Information Technology - Voluntary health organizations, publishers announce information initiative
Kaposi Sarcoma-Associated Herpes Virus - Small GTPase Rac1 links KSHV vGPCR to cytokine secretion and paracrine neoplasia
Kaposi Sarcoma-Associated Herpesvirus - Fetal mesencyhmal stem cells susceptible to KSHV infection
Kaposi Sarcoma-Associated Herpesvirus - Findings describe new data in kaposi sarcoma-associated herpesvirus research
Legal Issues - U.S. court upholds patent infringement suit against generic antibiotic maker
Leukemia - Chemotherapy drug combination shows promise for leukemia treatment
Leukemia - Girl in remission after leukemia diagnosis, twin sister's organ donation
Leukemia - Higher BMI associated with increased risk of AML, but not CLL in older women
Leukemia - Isolated extramedullary relapse appears common after Chemo-DLI
Liver Cancer - Genes with prognostic value in hepatocellular carcinoma identified
Liver Cancer - Quercetin induces selective growth inhibition/apoptosis in hepatic tumor cells
Lung Cancer - PI3-kinase pathway involved in early progression
Malignant Mesothelioma - MM cells expressing Slug have increased resistance to chemotherapeutic agents
Melanoma - Order of treatment critical for avoiding toxicity
Meningiomas - Galectin-3-binding sites, S100B may affect atypical meningioma aggressiveness
Metastases - Scientists study how cancer cells get out of control
Metastatic Melanoma - Taxanes may be treatment option for metastatic melanoma
Molecular Diagnostics - Multiplexed RT-PCR valuable for high throughput screening applications
Multiple Myeloma - Cancer drug study results indicate potential for treating multiple myeloma
Mutagenesis - Electrochemiluminescence assay shows point mutations in cancer samples
Nanotechnology - New protein holds promise for use in medicine and nanoscience
Neoplasia - Bcl-2-related genes important in tumor initiation/progression/therapy response
Neovascularization - Mast cell-derived angiopoietin-1 promotes plasmacytoma growth
Neurofibromatosis - Brain tumor study reveals why treatment efforts fail in genetic disorder
Neuroscience - Recent findings in neuroscience described
Neuroscience - The Wilms tumor gene is overexpressed in primary astrocytic tumors
Non-Hodgkin Lymphoma - Pesticide exposure may be associated with increased risk of NHL among women
Non-Small Cell Lung Cancer - Cancer vaccine trial data updated
Oncogenesis - Hepatitis C virus transfection produces liver cell growth and tumorigenesis
Oncogenesis - Research in oncogenesis provides new insights
Oncology - Chromosome changes are prognostic indicators in multiple myeloma patients
Oncology - Integrin signals link survival elements in recurrent prostate cancer
Oncology - Interleukin-10 may enable liver cancer to evade immune response mechanisms
Oncology - Paclitaxel halts angiogenesis at similar rates despite dissimilar scheduling
Oncology - Putative HOX11 target genes identified
Oncology - Researchers provide details of new studies and findings in the area of oncology
Oncology - SPRY2 activity in presence of wild-type and mutant BRAF clarified
Oncology - Studies advance knowledge in oncology research
Oncology - T cell type cancer predominates in Korean primary hepatic lymphoma cases
Oncology - Thrombin is involved in tumor invasion
Oral Cancer - Dietary zinc affects cox-2 expression and esophageal and tongue carcinogenesis
Oral Cancer - Finding abnormal p16 methylation pattern may aid in early oral cancer detection
Ovarian Cancer - Assay combination has potential to double response rate to chemotherapy
Ovarian Cancer - Cell lines analyzed using array-based comparative genomic hybridization
Ovarian Cancer - Company enrolls, initiates reviews phases of clinical trials for cancer drug
Ovarian Cancer - Progesterone signaling appears to influence disease risk
Pain Medicine - Outcomes of anesthetic-delivery device following mastectomy reported
Patents - Biotech company acquires gene encoding patent from Akademikliniken AB of Sweden
Patents - Diagnostics products developer announces patent issuance
Pediatric Oncology - Auto company retailers help raise $1 million for pediatric cancer research
Personnel - Biopharma company names new board member
Personnel - Biotechnology company appoints director of regulatory affairs
Personnel - California controller names Philip Pizzo, MD, to stem-cell oversight committee
Personnel - Health minister, battling cancer, says he likely will resign
Preventive Medicine - 20M smokers resolve to quit in 2005 again
Product Licensing - CAD, 3-D imaging companies announce licensing agreement for computed tomography
Product Licensing - Company inks licensing agreement in Mexico for Decapeptyl Depot, Decapeptyl LA
Product Licensing - License agreement for glioblastoma multiforme treatment candidate signed
Prostate Cancer - Calcitriol induces prostate-derived factor expression in tumor cells
Prostate Cancer - Company reaches milestone in development of prostate cancer classification test
Prostate Cancer - Experience with Vattikuti Institute prostatectomy reported
Prostate Cancer - Modified yeast assay improves detection of p53 abnormalities in prostate cancer
Prostate Cancer - More precise radiation therapy lets patients avoid erectile dysfunction
Prostate Cancer - Researchers report on case of spinal cord metastasis from prostate cancer
Prostate Cancer - Retinol, lycopene not significantly related to prostate cancer risk in study
Protein Methylation - Stable HeLa cell protein methylation produced by adenosine dialdehyde treatment
Proteomics - Properties of mutant alpha-tropomyosin were compared to wild protein
Proteomics - Zinc-finger protein TIS11b destabilizes angiogenic cytokine
Radiotherapy - Risk estimation made of hereditary effects due to radiation therapy
Renal Cancer - Angiogenesis inhibitors help patients with advanced renal cell carcinoma
Renal Cell Carcinoma - Use of retinoids in the treatment of renal cell carcinoma may be a futile effort
Rounded Atelectasis - Researchers report on asbestos-exposed worker with rounded atelectasis
Soft Tissue Sarcoma - Licensed oncology drug for soft tissue sarcoma in clinical trials at Wayne State
Spinal Cord Compression - Researchers report on vertebroplasty for tumor-related spinal cord compression
State Medicaid - Iowa Governor says raise cigarette tax to help fund Medicaid
Stem Cell Research - Nucleostemin plays important role in self-renewal of cancer cells
Stem Cell Transplantation - GVHD still a major limitation to successful hematopoietic SCT
Stem Cell Transplantation - HD radiochemotherapy followed by ASCT improves survival in follicular lymphoma
Stem Cell Transplantation - Non-myeloablative SCT safer than myeloablation for autoimmune diseases
Stress Induction - Multiple stress signals induce p73 beta accumulation
Surgical Technology - Imaging center announces noninvasive procedure for uterine fibroids
Surgical Technology - Report published examining forecast in eight major surgical specialties
Tobacco Use - American Lung Association gives Oregon poor grades
Transitional Cell Carcinoma - Researchers report on transitional cell carcinoma in renal transplant recipients
Tumor Suppression - Cdk inhibitor p21 has tumor suppressor function in colon
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