Proteomics
Zinc-finger protein TIS11b destabilizes angiogenic cytokine
Published in Cancer Weekly, January 25th, 2005
"Vascular endothelial growth factor (VEGF) is an angiogenic cytokine, which plays a major role in tumor angiogenesis. VEGF mRNA expression is controlled by hypoxia, growth factors and hormones through both transcriptional and post-transcriptional mechanisms. VEGF mRNA has a short half-life and its abundance is regulated by the binding of stabilizing (HuR, hRNP-L) and still uncharacterized destabilizing proteins to its 3'-untranslated region," investigators in France report.
"Here, we report that the ACTH-regulated zinc-finger protein TIS11b and its homologs TIS11 and TIS11d interact with...
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Source: Cancer Weekly (2005-01-25)
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