Cell Biology

Study of hypoxia and new gene reveals early-stage action of p53 gene

Published in Cancer Weekly, January 25th, 2005

Researchers have known for a decade that the p53 tumor suppressor gene is important for killing cells as they proliferate under low-oxygen conditions inside tumors.

As tumors grow they outstrip their oxygen supply. If a cell has a normal p53 gene, the p53 protein will eliminate cancerous cells, keeping tumor growth at bay. Under conditions of stress to the cell - such as radiation or chemotherapy and hypoxia - p53 normally eliminates tumors.

Hypoxia, however, induces p53 to mutate: The less oxygen, the more mutations in the p53 gene, so cancer cells are not killed; instead, they proliferate. A team led by Wafik El-Deiry, MD, PhD, associate professor,...

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Source: Cancer Weekly (2005-01-25)

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