Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . February 8th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Breast Cancer - Deficient DNA repair capacity associated with increased cancer risk
Breast Cancer - MIB-1 and c-erbB-2 expression influence tumor cell morphology
Cancer Surgery - Inflammatory cytokines promote tumor recurrence in lung
Environmental Health - Study: Most childhood cancers probably due to prenatal exposure to pollutants
Nasopharyngeal Carcinoma - Epstein-Barr virus DNA assessment suitable for tumor monitoring
Actinic Keratosis - Company reports positive results from phase I clinical trial for PEP005 Topical
Adverse Drug Reaction - Common antidepressants lower effects of tamoxifen in many women
Adverse Drug Reaction - Washington State company offers DNA tests for adverse drug reactions
Angiology - Recent studies add new data to angiology research
Apoptosis - NDRG1 gene is necessary for p53-dependent apoptosis
Awards - Hebrew University professor wins Wolf Prize in Medicine
Basal Cell Carcinoma - Basal cell carcinoma may arise outside the stem cell population
Bladder Cancer - TP53 alterations are associated with tumor progression
Breast Cancer - Adding radiotherapy to chemotherapy improves high-risk patients' survival
Breast Cancer - Annual mammogram, doctor visits are enough for breast cancer follow-up
Breast Cancer - Bonefos approved as adjuvant treatment of breast cancer
Breast Cancer - Breast cancer coalition launches Pennsylvania funding program for research
Breast Cancer - COBRA1 inhibits AP-1 transcriptional activity in transfected cells
Breast Cancer - Chemotherapeutic drug gets 2 new European approvals as breast cancer treatment
Breast Cancer - Findings describe new data in breast cancer research
Breast Cancer - Gene vaccine protects mice against development of HER2/neu breast cancer
Breast Cancer - Hispanics may have different breast cancer phenotype than non-Hispanic whites
Breast Cancer - IL-2 cultures fail to measure chromosomal radiosensitivity in study patients
Breast Cancer - Inflammatory Breast Cancer Research Foundation expands collaboration with SIDMAP
Breast Cancer - Job stress is not a risk factor
Breast Cancer - Nomogram of limited value in predicting non-SLN involvement after SN+ biopsy
Breast Cancer - Pre-biopsy breast massages transport epithelial cells to sentinel lymph nodes
Breast Cancer - Progesterone receptor by immunohistochemistry predicts breast cancer outcome
Breast Cancer - Prognostic value of intra-tumoral estradiol level determined
Breast Cancer - Pure antiestrogens yield higher response rates than SERMs
Breast Cancer - Radiation found useful in breast cancer after surgery
Breast Cancer - Reclassification sought for Biofield diagnostic system
Breast Cancer - Researchers present mastectomy pain management techniques at conference
Breast Cancer - STK15 may be a low-penetrance type breast-cancer susceptibility gene
Breast Cancer - Screening program in Europe deemed a success
Breast Cancer - Shoppers fight breast cancer at outlet mall chain's annual awareness day
Breast Cancer - U.S. FDA approves Abraxane, first in new class of protein-bound particle drugs
Breast Cancer - U.S. FDA approves albumin-bound nanoparticle paclitaxel for breast cancer
Business & Finance - Pharma company updates 2004, provides 2005 financial guidance
Business Update - Biotechnology company clarifies 3:1 split timing, announces stem cell initiative
Business Update - Company updates cancer and HIV clinical-development programs
Business Update - Fox Chase Cancer Center selected for Cancer Information Service contract award
Business Update - Humanized antibodies developer offers status of partnerships, drug development
Business Update - Liposome vaccine to be company's focus in 2005
Business Update - Pharmaceutical company outlines corporate restructure, research plans for 2005
Business Update - VTAK, a new company, to focus on diagnostic and therapeutic cancer products
Business and Finance - Pharmaceutical company announces corporate goals
Cadmium Toxicity - Non-toxic cadmium dose alters gene expression in testes
Cancer Genetics - Long-term OC use reduces ovarian cancer risk among BRCA1/2 carriers
Cancer Genetics - Sequence comparison made of primate BRCA1 loci and corresponding proteins
Cancer Prevention - IHC and Huntsman Cancer Institute team up to fight cancer
Cancer Prevention - Study shows common colorectal screening test often fails
Cancer Research - Students raise money in grass-roots effort to fund cancer research
Cancer Risk Factors - Drinking alcohol increases risk for cancer
Cancer Risk Factors - Study finds no evidence of a "cancer personality"
Cancer Therapy - Antibodies enter clinical trials at ImClone Systems
Cancer Therapy - Antitumor mechanisms of irofulven clarified
Cancer Therapy - Application for MRI published in leading cancer journal
Cancer Therapy - Cancer vaccines: A two-pronged attack?
Cancer Therapy - Oblimersen and vinorelbine diminish malignant lung tumors in murine models
Cancer Therapy - Oncolytic vesicular stomatitis virus localizes in breast cancer cells
Cancer Therapy - Pharma company receives FDA fast track status for anorexia/cachexia treatment
Cancer Therapy - Research sheds light on how cancer cells become resistant to treatment
Cancer Therapy - Researchers provide details of new studies and findings in the area of cancer therapy
Cancer Therapy - Selective inhibition of angiopoietin-2 suspends angiogenesis and tumor growth
Cancer Therapy - Src kinase blockade prevents tumor extravasation and metastasis
Cancer Vaccine - Acid-degradable particles for protein-based vaccines enhances survival rate
Cancer Vaccine - Anti-CD137 antibody augments antitumor efficacy of dendritic cell vaccines
Cancer Vaccine - Immunological prevention of multigene cancer syndrome
Cancer Vaccine - Progress in developing tumor cell vaccine reviewed
Cancer Vaccines - Recent findings illuminate research in cancer vaccines
Cancer Vaccines - Researchers' data advance cancer vaccines research
Cell Biology - Von Hippel-Lindau protein modulates microtubule dynamics at cell periphery
Cervical Cancer - Interventions needed to increase Pap testing among Vietnamese women in the U.S.
Cervical Cancer - Lack of population-based screening in Ireland blamed for higher disease rate
Cervical Cancer - Report on cervical cancer by women in office shows no state excels in prevention
Cervical Cancer - Studies advance knowledge in cervical cancer research
Cervical Dysplasia - Vaccine to treat cervical dysplasia licensed to Cancer Research Technology
Chemoprevention - Resveratrol may produce preventive effects despite low bioavailability
Childhood Leukemia - Fruits containing vitamin C, potassium may reduce risk of childhood leukemia
Chronic Liver Disease - Mitochondrial dysfunction is a major component of steatohepatitis progression
Clinical Trials - Phase 1 trial initiated to set cancer drug dosing in patients with solid tumors
Collaborations - ClinPro, clinical research service firm enter strategic alliance in Israel
Collaborations - Collaborative research agreement initiated to develop cancer-effective analogs
Collaborations - Combinature announces partnership on NMR-aided drug-discovery project
Collaborations - Company amends collaboration with GlaxoSmithKline
Collaborations - Lymphoma research collaboration expanded
Collaborations - Proteomics-based drug discovery company signs use agreement with GlaxoSmithKline
Collaborations - Sanofi-aventis signs oncology collaboration with biopharmaceutical company
Collaborations - Taiwan-based oncology-focused biotech company forms alliance with P&GP
Colon Cancer - Colonoscopy still most effective colorectal cancer screening method
Colon Cancer - VEGF genotype correlates with colorectal adenocarcinoma progression
Cryopreservation - Cryobanking testicular tissue from young boys with cancer is acceptable strategy
Diagnostics - AmpliChip CYP450 test receives U.S. FDA clearance
Diagnostics - Application filed with FDA for colorectal cancer test
Diagnostics - Company completes ELISA CA-125 tumor marker development
Diet & Nutrition - North Carolina residents smoke and eat too much, don't exercise enough
Diet & Nutrition - Vegetable soup consumption decreases oxidative stress/biomarkers of inflammation
Diet and Nutrition - Industry group notes updated 2005 Dietary Guidelines recommend eating more fish
Disease Associations - Carbohydrate-based drug-development company complies with NASDAQ; file closed
Disease Threat - Cancer surpasses heart disease as top killer of Americans under 85
Drug Delivery - Anticancer sPLA2 -degradable prodrug liposomes show promise
Drug Delivery - Liposomes targeting tumor vessel systems help eradicate cancerous cells
Drug Development - Drug pipeline expanded with three preclinical candidates
Drug Development - NDA submitted to U.S. FDA for advanced prostate cancer drug
Drug Development - Novel apoptosis-inducing antitumor agents also target tumor vasculature
Drug Development - Phase I PDX study initiated in patients with non-small cell lung cancer
Drug Development - Regulatory clearance sought for BLX-883 clinical studies
Drug Development - U.S. NIH grant to fund development of erythropoiesis-stimulating protein
Endometrial Cancer - Mayo Clinic recommends broadening treatment to prevent disease recurrence
Environmental Health - Most childhood cancers "probably" down to prenatal exposure to pollutants
Environmental Health - Newspaper study finds toxic air in communities around chemical plants
Environmental Health - Surgeon general releases national health advisory on dangers of radon
Enzymology - Sphingomyelinase regulates microvascular function but not tumor immunity
Epstein-Barr Virus - Epstein-Barr virus detected in lymphoma cells in mantle cell lymphoma patient
Ewing Sarcoma - Spinal cord Ewing sarcoma metastasis: presentation of one case
Finance - AdZyme maker raises $15.5 million to advance product pipeline into clinic
Finance - Avastin maker reports strong 2004 results
Finance - Biotech company announces quarterly dividend for 6% convertible preferred stock
Finance - Cellular-engineering-focused company announces completion of private placement
Finance - Drug company reports strong fourth-quarter revenue growth
Finance - Electroporation therapy company announces equity financing
Gastroenterology - New findings in the area of gastroenterology described
Gastroenterology - Restored receptor-type protein tyrosine phosphatase limits pancreatic cancer
Gastroenterology - Somatostatin receptor subtype 2 abates pancreatic cancer vessel formation
Gastroenterology - Surprising study shows Plavix risk for returning ulcers
Gastrointestinal Cancer - Biotech company begins enrollment of phase 1/2a trial of RAV12
Gene Expression Profiling - DASL Assay launches for gene expression profiling of paraffin-embedded samples
Graft-Versus-Host Disease - Antithymocyte globulin decreases risk of GVH and host-versus-graft reactions
Graft-Versus-Host Disease - Partial CD8+ T-cell depletion of PBMC ASCT insufficient to prevent GVHD
Gynecologic Cancers - Effects of ERT and combined HRT on neoplasia occurrence reviewed
Gynecologic Cancers - Pilot study of fluorescence spectroscopy screening trial reported successful
Gynecology - Recent findings in gynecology described
HIV/AIDS Cancer - Research in HIV/AIDS cancer provides new insights
Haploidentical Stem Cell Transplantation - Automated graft processing devices ensure feasibility of haploidentical SCT
Haploidentical Stem Cell Transplantation - Haploidentical parental donor viable option for children lacking identical donor
Health Promotion - Antismoking organization launches educational program on second-hand smoke
Healthcare Access - African Americans half as likely to receive surgery for esophageal cancer
Helicobacter Pylori - H. pylori cag pathogenicity island disrupted in majority of patient isolates
Hematopoiesis - EDAG regulates proliferation and differentiation of hematopoietic cells
Hepatitis B Therapy - Study shows peginterferon alfa-2b effective monotherapy for chronic hepatitis B
Hepatocellular Carcinoma - Yttrium-90 TheraSphere shows promise for treatment of unresectable tumors
Herpesvirus - Murine gammaherpesvirus 68 glycoprotein B processing similar to KSHV gB & CMV gB
Hypertension - Drug maker notes risk of OTC decongestants in high blood pressure sufferers
Immunoreactivity - Eosinophils regulate T cell subset selection through indoleamine 2,3-dioxygenase
Infectious Disease Research - Company awarded $24 million to study genetics of infectious disease and vaccines
Kidney Cancer - CD10 expressed in some chromophobe renal cell carcinomas
Legal Issues - California vitamin company to pay $3.6 million to settle fraud charges
Leukemia - Cord blood transplantation now a viable option for adult leukemia patients
Lung Cancer - Angiotensin-(1-7) inhibits lung cancer cell growth, data shows
Lymphocytic Choriomeningitis Virus - Antigen-independent T cells do not develop during chronic viral infection
Lymphoma - Stem cell transplants viable option for patients suffering from lymphoma and HIV
Malignant Melanoma - Phase I clinical trial begins using MedPulser System
Mammography - Computer-assisted mammography may improve accuracy of reading
Melanoma - MIA level of questionable use for serum diagnostics in pregnant women, children
Melanoma - Recent studies add new data to melanoma research
Melanoma Vaccine - Mouse MAGE-derived H-2Kb-restricted CTL epitopes characterized
Mergers & Acquisitions - Drug developer acquires Aptamera Inc., appoints member to board
Mergers & Acquisitions - Radio frequency ablation systems development company repays debt
Mergers & Acquisitions - Therapeutics company acquires Amedis Pharmaceuticals and secures new financing
Mergers & Acquisitions - U.K. cancer specialist to acquire U.S. cancer-focused company Aptamera
Molecular Biology - Pokemon protein puts new cancer treatment on the cards
Multiple Myeloma - Injection phase 3 trial initiated in newly diagnosed multiple myeloma patients
Mycobactetium Brumae - Mycobactetium brumae caused catheter-related bloodstream infection
Neural Stem Cell Research - Fetal neural progenitors can be the target for tumor transformation
Obstetrics - Later-stage cancer in pregnant women isn't more aggressive
Oncogenesis - Fragile histidine triad gene inactivation supports bladder cancer formation
Oncology - ABC-Tox microarray seeks out genes involved in cancer drug resistance
Oncology - Genetic damage measured in cancer patients during radiotherapy
Oncology - Hypoxia inducible factor-1 drives key elements of tumor angiogenesis
Oncology - Interleukin-12 gene therapy fights liver cancer in immunosuppressed mice
Oncology - Promising cancer chemotherapeutics work by immobilizing endothelial cells
Oncology - Ras-induced interleukin-8 expression contributes to oncogenesis
Oncology - Recent studies add new data to oncology research
Oncology - Researchers describe findings in oncology studies
Oncology - Researchers detail new studies and findings in the area of oncology
Oncology - Researchers report on percutaneous resection of renal pelvic tumors
Oncology - Researchers report on prevalence of unmet needs in veterans with advanced cancer
Oncology - Screened polymer libraries highlight optimal cancer gene therapy vectors
Oncology - Small interfering RNA augments hypoxia and radiation induced tumor cell death
Oncology - The carbohydrate inositol hexaphosphate is a potent inhibitor of vessel growth
Oncology - The ectodermal neural cortex 1 gene is upregulated in hairy cell leukemia
Oral Cancer - COX-2 levels are elevated in smokers
Osteopoikilosis - Retrospective study examines 10 cases of osteopoikilosis
Ovarian Cancer - Carcinogenesis rat model develops human-like preneoplasia and neoplasia
Ovarian Cancer - Combining paclitaxel with NFkappaB inhibitor might boost efficacy of the former
Ovarian Cancer - Epigenetic-based therapies have potential to resensitize tumors to chemotherapy
Ovarian Cancer - Findings describe new data in ovarian cancer research
Ovarian Cancer - No association found between ovulation-inducing drugs and increased cancer risk
Pain Medicine - Pharma company begins shipment of Palladone capsules
Palliative Care - Practitioners consider mentorship important in specialist practice transition
Pancreatic Cancer - New findings in the area of pancreatic cancer detailed
Parkinson Disease - Van Andel Institute to research Parkinson disease
Patents - Biotechnology company files citations relevant to Benitec patent
Patents - Notice of Allowance issued for blood test that detects cervical, other cancers
Patents - Patent issued for enhanced detection sensitivity in DNA materials analysis
Personnel - Biothrax maker names Dr. Steven Chatfield named chief scientific officer
Personnel - Cancer Lifeline announces retirement of executive director
Personnel - Colon Cancer Alliance names Leonard S. Jacob, MD, PhD, to its board
Personnel - Oncology-focused drug company names 7 to clinical advisory board
Personnel - Pharma company names member to scientific and technical advisory board
Pneumocystis Carinii Therapy - Piperazine-linked bisbenzamidines active against Pneumocystis carinii
Preventive Medicine - HHS promotes new Medicare preventive benefits for better senior health
Product Licensing - Pharmaceutical company granted distribution rights for Aloxi in Indonesia
Product Licensing - Therapeutics company licenses DISC-HSV and DISC-GM-CSF vector platforms
Prostate Cancer - Bicalutamide a cost-effective treatment for locally advanced disease
Prostate Cancer - Hormone therapy drugs bring risks
Prostate Cancer - Obesity may affect accuracy of prostate screening
Prostate Cancer - Protein kinase A regulatory subunits are targets for cancer gene therapy
Prostate Cancer - Researchers report on molecular mechanisms in hormonorefractory prostate cancer
Prostate Cancer - Researchers report on prostate cancer diagnosing and staging
Prostate Cancer - Serum PSA levels decline in antileukemic chemotherapy patient
Prostate Cancer - Tumor hypoxia may have prognostic value in radiation-treated patients
Pseudomonas Aeruginosa - Carbapenem-resistant Pseudomonas aeruginosa outbreak strain produced VIM-8
Reproductive Medicine - Dietary copper supplement prevents adverse sperm effects produced by TTM
Reservatrol - Resveratrol-induced apoptosis in prostate cancer cells mediated by PKC-alpha
Skeletal Tuberculosis - Skeletal tuberculosis may be suspect in cases of long-standing pain and swelling
Stem Cell Transplantation - HSCT survivors have increased risk of secondary nonhematologic malignancies
Stem Cell Transplantation - Hyponatremia and SIADH are common complications following SCT
Stem Cell Transplantation - NK cell immunotherapy is used to treat AML patients following HSCT
Stem Cell Transplantation - Standard IV busulfan dose in children may not fall within AUC reference range
Stem Cell Transplantation - T-cell-depleted megadose SCT from mismatched donor viable option for adults
Stem Cell Transplantation - Trimetrexate/denileukin diftitox depletes T cells from PBMC/UCB grafts
Testicular Granulocytic Sarcoma - Researchers report on case of testicular granulocytic sarcoma
Tobacco Use - Health groups cheer as high court upholds limits on tobacco promotion
Tophaceous Gout - Researchers report on tophaceous gout involving anterior cruciate ligament
Umbilical Cord Blood Transplantation - Unrelated UCB transplant alternative option to HSC in children and adults
Vaccine Development - Combined vaccines synergize to resist cancer growth
Vaccine Development - Lipopeptide epitopes trigger Th1-dependent protective immunity
Vaccine Efficacy - Statistical tests to determine vaccine efficacy evaluated
Virology - Genetic instability allows tumor cells to escape suicide gene therapy
Virology - In situ hybridization rapidly identifies EBV infection in single cells
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