Drug Development
Novel apoptosis-inducing antitumor agents also target tumor vasculature
Published in Cancer Weekly, February 8th, 2005
In a recent study from the United States, a "series of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromenes was identified as apoptosis-inducing agents through our cell-based apoptosis screening assay."
"Several analogues from this series, MX-58151, MX-58276, MX-76747, MX-116214, MX-126303, and MX-116407, were synthesized and further characterized," according to S. Kasibhatla and coauthors at San Diego-based Maxim Pharmaceuticals. "MX-116407, a lead compound from this series, induced apoptosis with an EC50 of 50 nmol/L...
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Source: Cancer Weekly (2005-02-08)
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