Enzymology
Sphingomyelinase regulates microvascular function but not tumor immunity
Published in Cancer Weekly, February 8th, 2005
"Previous studies provided evidence that MCA/129 fibrosarcomas and B16 melanomas grow 2- to 4-fold faster in acid sphingomyelinase (asmase)-deficient mice than in asmase+/+ littermates and are resistant to single-dose irradiation due to inability to mount an apoptotic response in tumor microvascular endothelium. However, others postulated the differences might be associated with a host antitumor immune response in asmase+/+ mice that is not expressed in asmase-/- mice due to phenotypic deficiency in antitumor immunity," scientists in the United States say.
"The present studies...
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Source: Cancer Weekly (2005-02-08)
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