Lymphocytic Choriomeningitis Virus

Antigen-independent T cells do not develop during chronic viral infection

Published in Cancer Weekly, February 8th, 2005

Antigen-independent memory CD8 T cells do not develop during chronic viral infection.

"Memory T cells can persist for extended periods in the absence of antigen, and long-term T cell immunity is often seen after acute infections. Paradoxically, there have been observations suggesting that T cell memory may be antigen-dependent during chronic infections. To elucidate the underlying mechanisms we have compared memory CD8 T cell differentiation during an acute versus chronic infection by using the mouse model of infection with lymphocytic choriomeningitis virus. We found that during a chronic infection virus-specific CD8 T cells failed to acquire the cardinal memory T cell...

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Source: Cancer Weekly (2005-02-08)

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