Oncology
Interleukin-12 gene therapy fights liver cancer in immunosuppressed mice
Published in Cancer Weekly, February 8th, 2005
According to published research from Japan, "immunosuppressive therapy for organ transplantation is essential for controlling rejection. When liver transplantation is performed as a therapy for hepatocellular carcinoma (HCC), recurrent HCC is one of the most fatal complications. In this study, we show that intratumoral murine interleukin-12 (mIL-12) gene therapy has the potential to be an effective treatment for malignancies under immunosuppression."
"C3H mice (H-2kappa ), injected with FK506 (3 mg/kg) i.p., were s.c. implanted with 2.5 x 106 MH134 cells...
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Source: Cancer Weekly (2005-02-08)
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