Ovarian Cancer

Carcinogenesis rat model develops human-like preneoplasia and neoplasia

Published in Cancer Weekly, February 8th, 2005

A rat model of ovarian carcinogenesis has been modified and improved, researchers report, to produce pathogenetically human-like ovarian preneoplastic and neoplastic lesions.

Fox Chase Cancer Center researcher S.L. Stewart and colleagues explained that they administered "a significantly lower dose (2 to 5 mcg per ovary) of 7,12-dimethylbenz(a)anthracene (DMBA) ...to the one ovary to maximally preserve its structural integrity. DMBA-induced mutagenesis was additionally combined with repetitive gonadotropin hormone stimulation to induce multiple cycles of active proliferation of the ovarian surface epithelium."

They treated the rats "in 3 arms of...

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Source: Cancer Weekly (2005-02-08)

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