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Reproductive Medicine

Dietary copper supplement prevents adverse sperm effects produced by TTM

Published in Cancer Weekly, February 8th, 2005

Dietary copper supplementation prevents the adverse sperm effects produced by tetrathiomolybdate.

"Based on its ability to chelate copper, TTM is being studied as an antiangiogenic agent for cancer therapy. The purpose of this study was to evaluate the toxicity of TTM and the protection of copper supplementation on the reproductive capability of male and female CD(R) rats," researchers in the United States report.

"Doses of 0, 1, 4, and 12 mg/kg/day with copper supplementation (110 mg/kg of diet) were given by gavage. There were no effects on the estrous cycle or reproductive indices, or maternal toxicity in any female dose group," wrote A.V....

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