Stem Cell Transplantation

NK cell immunotherapy is used to treat AML patients following HSCT

Published in Cancer Weekly, February 8th, 2005

Highly enriched and IL-2-stimulated NK cell immunotherapy is used to treat children with acute myelogenous leukemia following haploidentical stem cell transplantation.

"According to recent research from Germany, "Natural killer (NK) cells are thought to be of benefit in HLA-mismatched hematopoietic transplantation (H-SCT). Therefore, we developed a protocol for clinical-use expansion of highly enriched and IL-2-stimulated NK cells.

"Purification of unstimulated leukaphereses by a 2-step T cell depletion with a final CD56 enrichment procedure leads to a mean purity of 95% CD56+CD3- NK cells with a 4- to 5-log depletion of T cells."

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Source: Cancer Weekly (2005-02-08)

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