Published in Cancer Weekly, February 8th, 2005
The VHL protein protects MTs "from destabilization by nocodazole treatment," researchers in the Netherlands explained. "Based on this fixed-cell assay with static end points, VHL has been reported to directly stabilize the MT cytoskeleton."
"To investigate the dynamic changes in MTs induced by VHL in living cells," M.P. Lolkema and colleagues at the University of Utrecht "measured the influence of VHL on tubulin turnover using fluorescence recovery after photobleaching (FRAP)."
"To this end, we engineered VHL-deficient renal...
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