Chemoprevention

Resveratrol may produce preventive effects despite low bioavailability

Published in Cancer Weekly, February 8th, 2005

A recent report described high absorption but very low bioavailability of oral resveratrol in humans.

According to the report from the United States, "The dietary polyphenol resveratrol has been shown to have chemopreventive activity against cardiovascular disease and a variety of cancers in model systems, but it is not clear whether the drug reaches the proposed sites of action in vivo after oral ingestion, especially in humans. In [our] study, we examined the absorption, bioavailability, and metabolism of ¹⁴C-resveratrol after oral and i.v. doses in six human volunteers."

T. Walle and colleagues of the Medical University of South...

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Source: Cancer Weekly (2005-02-08)

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