Prostate Cancer
CYP3A4*1B/CYP3A43*3 may influence risk of prostate cancer/disease severity
Published in Cancer Weekly, February 22nd, 2005
According to a study from the United States, "The CYP3A genes reside on chromosome 7q21 in a multigene cluster. The enzyme products of CYP3A4 and CYP3A43 are involved in testosterone metabolism. CYP3A4 and CYP3A5 have been associated previously with prostate cancer occurrence and severity.
"To comprehensively examine the effects of these genes on prostate cancer occurrence and severity, we studied 622 incident prostate cancer cases and 396 controls."
"Substantial and race-specific linkage disequilibrium was observed between CYP3A4...
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Source: Cancer Weekly (2005-02-22)
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