Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . March 1st, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Breast Cancer - Compound extracted from rare plant shows therapeutic promise
Breast Cancer - Enzyme identified that activates cancer cell growth and invasion
Cancer Risk Factors - COX-2 levels parallel microvessel density in non-melanoma skin cancer patients
Exercise - Predictors of adherence to exercise in colon cancer survivors reported
Oncology - CEACAM1 is an angiogenic switch in urinary bladder cancer
Acute Myelogenous Leukemia - Genes with prognostic value identified in AMLs with normal karyotype
Acute Myeloid Leukemia - B-cell translocation gene 1 biomaker monitors acute myeloid leukemia remission
Acute Myeloid Leukemia - XPD genetic variation predicts treatment outcome and AML risk after chemotherapy
Alzheimer Disease - Nanotechnology company expands application of Alzheimer detection technology
Assisted Suicide - 74-year-old man charged with helping ailing friend commit suicide
Brain Cancer - The attenuated adenovirus ONYX-015 fights glioma proliferation
Breast Cancer - Breast carcinoma cell line is resistant to DNA-damaging drugs
Breast Cancer - Breast myoepitheliomas should be managed as potentially malignant tumors
Breast Cancer - CYP17 gene variant interactions affect breast density, possibly cancer risk
Breast Cancer - Common variant of CASP8 gene associated with reduced risk of breast cancer
Breast Cancer - Company expects its system to be part of NCI partial breast irradiation study
Breast Cancer - Estrogen receptor genetic variants and cancer risk investigated
Breast Cancer - Ethnic differences in breast density to be examined
Breast Cancer - FDA approves InSite Her-2/neu Kit
Breast Cancer - Fashionable to Care program launches to support breast cancer research
Breast Cancer - Identification of second breast cancer gene announced
Breast Cancer - Maine professor recounts battle with breast cancer
Breast Cancer - Medical imaging company plays role in clinical trial of drug for breast cancer
Breast Cancer - New immunotherapeutic approach evaluated for advanced disease
Breast Cancer - Obesity and weight gain associated with poorer breast cancer survival
Breast Cancer - Platelet-derived LAP supports progression of osteolytic bone metastases in mice
Breast Cancer - Radar-based imaging system penetrates dense breast tissue
Breast Cancer - Recent findings in breast cancer described
Breast Cancer - Study seeks to clarify hypothyroidism/breast cancer association
Breast Cancer - Tamoxifen treatment reduces patients' risk of heart disease
Breast Cancer - Technology company uses virtual clones to predict breast cancer therapy
Breast Cancer - Truck driver occupation linked to increased BRCA1/2 male breast cancer mutation
Business & Finance - Biotech company reports pipeline update, financial performance
Business & Finance - Oncology drug maker reports financial performance, pipeline update
Business Update - Boehringer Ingelheim to discontinue development of bivatuzumab mertansine
Business Update - ComGenex transfers to Echelon jointly developed IP for cancer compounds
Business Update - Companies amend milestones in cancer agreement
Business Update - Disease management company awarded new accounts
Business Update - PREVU* POC Skin Sterol Test available for sale in Canada, U.S. markets
Business Update - Pharma company adds to product line, enters partnership
Business Update - Pharma company signs sales and marketing contract for OTC Products
Business Update - Vaccine developer may receive milestone payment for human papillomavirus vaccine
Cancer Genetics - BRCA2-related protein repairs broken DNA
Cancer Genetics - Researchers provide details of new studies and findings in the area of cancer genetics
Cancer Genetics - SLIT2 and SLIT3 genes frequently methylated in gliomas and colorectal cancers
Cancer Prevention - Arizona health officials craft plan to fight cancer
Cancer Research - DAVANAT and DAVANAT/5-FU well tolerated in patients with advanced solid tumors
Cancer Research - Society launches Daffodil Days campaign to raise money through Flower of Hope
Cancer Research - U.S. government releases updated list of cancer-causing agents
Cancer Risk - Larger babies have higher risk of certain cancers in adulthood
Cancer Risk Factors - Overexpressed c-Myc in liver disease patients may cause liver cancer
Cancer Survival - Child cancer survivors get high scores
Cancer Therapy - $10M funds study to determine men's role in HPV transmission
Cancer Therapy - 5-fluorouracil inhibits exosome-dependent degradation of polyadenylated rRNAs
Cancer Therapy - Activated JNK in mitochondria linked to paclitaxel-induced cytotoxicity
Cancer Therapy - As2 O3 causes caspase-independent cell death in cervical cancer cells
Cancer Therapy - Foundation goes public to ask for funds for cancer center
Cancer Therapy - Fusion transgene elicits a robust immunological response to tumor cells
Cancer Therapy - Host immune system should be considered when treating MSI tumors
Cancer Therapy - Mutant epidermal growth factor receptor enhances susceptibility to ZD6474
Cancer Therapy - New cancer prevention technology prevents polyps from turning into colon cancer
Cancer Therapy - Pfizer cancer drug shows such promise that trial ended early
Cancer Therapy - Pharma company announces orphan drug designation accepted for RX-0201
Cancer Therapy - Recent studies add new data to cancer therapy research
Cancer Therapy - Researchers describe findings in cancer therapy studies
Cancer Therapy - SU5416 treats lung cancer by blocking Kit-induced VEGF expression
Cancer Vaccine - CD1d-dependent NK T cells are adjuvants in T cell-mediated immunotherapy
Cancer Vaccine - Functional memory CD8+ T cells generated in vivo without evident T help
Cancer Vaccine - Prolonged culture of vaccine-primed lymphocytes decreases antitumor killing
Cancer Vaccines - Research add new data to cancer vaccines body of knowledge
Cancer Vaccines - Studies add new findings to cancer vaccines body of knowledge
Carcinogenesis - Findings describe new data in carcinogenesis research
Carcinogens - Eugenol metabolites produce DNA damage in human genes
Carrier Proteins - Bacterial phosphocarrier protein analyzed, solution structure reported
Cervical Cancer - IL-10, TNF-alpha levels may indicate stage of cervical lesions induced by HPV
Cervical Cancer - Researchers' data advance cervical cancer research
Chernobyl Cancer Risk - Statistically significant cancer increase in most contaminated Chernobyl region
Chronic Lymphocytic Leukemia - Withdrawal of clinical trial protocol in chronic lymphocytic leukemia announced
Clinical Trials - Suicide gene therapy prolongs the survival of patients with malignant glioma
Collaborations - Curis to co-develop cancer drug
Collaborations - European rights obtained to TUO-gene expression profile
Colon Cancer - Combination of DHA and p-XSC shows promise for treatment
Colon Cancer Risk - ALOX and COX polymorphisms influence colon cancer risk in Caucasians
Colorectal Cancer - Benefit of Eloxatin-based chemo plus bevacizumab for colorectal cancer reported
Colorectal Cancer - Results presented for Avastin plus the FOLFOX4 chemotherapy regimen
Complementary & Alternative Medicine - Researchers blend folk treatment, high tech for promising anticancer compound
Congestive Heart Failure - Long-standing anemia of any cause can cause left ventricular hypertrophy
Correction - Bonefos receives FDA approvable letter as adjuvant treatment of breast cancer
Crohn Disease - Study evaluates new treatment in Crohn Disease
Cutaneous Malignant Melanoma Risk Factors - Inverse association between vitamin A and cutaneous malignant melanoma risk
Cytomegalovirus - Treatment for AIDS-related cytomegalovirus receives positive recommendations
Dermatology - New findings in the area of dermatology described
Diabetes Education - Alliance of healthcare insurers sponsors diabetes education program
Diagnostics - Companies launch strategic alliance for cancer studies
Diagnostics - Czech Republic signs CT Laser Mammography agreement
Diagnostics - DOBI Medical signs new distributors in Brazil and the Netherlands
Diagnostics - Technology company introduces ImageChecker LS CAD system
Diet & Nutrition - Health benefits of citrus limonoids explored
Drug Delivery - Researchers' findings advance drug delivery research
Drug Development - Cancer-focused drug company expands development program for lead cancer drug
Drug Development - Combidex to be reviewed by U.S. FDA Oncologic Drugs Advisory Committee
Drug Development - Company announces new indication, CLL, for GCS-100LE clinical trial program
Drug Development - Microarray, software launched for comparative genomic hybridization studies
Drug Development - Pharmaceutical firm reports clinical pipeline update
Drug Development - SERM plus 17beta-estradiol may have promise against breast cancer or as HRT
Drug Development - Three-year agreement with GSK supports drug discovery and development efforts
Environmental Health - Group warns U.S. EPW to exclude carbon monoxide from Clear Skies Act of 2005
Enzymology - New data illuminates research in enzymology
Epidemiology - HTLV-1 significantly associated with lymphoid malignancies in Dominica
Epstein-Barr Virus - Lytic cycle gene regulation of Epstein-Barr virus analyzed
Finance - Cancer-focused pharmaceutical co. completes $32.5 million sale of common stock
Finance - Drug developer announces acceleration of employee stock option vesting
Finance - FavId maker announces pricing of initial public offering
Finance - Genomics-based pharmaceutical reports net loss of $90.4 million
Finance - Imaging device company announces fourth quarter and year-end 2004 results
Finance - Immunotherapy company announces increased 2004 revenue despite Q4 dip
Finance - Radiation therapy company reports third quarter financial results
Gastric Cancer - Expression analysis identifies alterations in AP-1 pathway induced by gastrin
Gastroenterology - Association between H. pylori and reflux disease varies with region
Gastroenterology - Reports advance knowledge in gastroenterology research
Gene Research - Genetic test company licenses markers for Ashkenazi Jewish multi-disease panel
Genetic Engineering - Genetically modified cytolytic T cells recognize and kill glioblastoma
Genetics and Genomics - HLA profiles differ with cancer type in hepatitis C virus-positive patients
Glioma - PTEN regulates c-Met-dependent gene expression in glioma cells
Gynecologic Cancers - MIS plus X-linked clonality analysis helps diagnose synchronous tumors
HIV/AIDS Testing - HIV testing campaign targets African American and Latina women
HIV/AIDS Therapy - Lovastatin potentiates antitumor effects of saquinavir against lymphoma cells
Health Risks - Board hears health concerns from Iowa bomb builders
Healthcare Coverage - Changes in reimbursement structure to aid greater adoption of brachytherapy
Heathcare Coverage - PET equipment maker comments on Medicare and Medcaid coverage for PET
Helicobacter Pylori - H. pylori-induced spermine oxidation results in apoptosis and DNA damage
Hematology - Lamivudine-induced mutants may link hepatitis B to acute myeloid leukemia
Hepatoblastoma - Conductin is a direct target gene of WNT signaling hepatoblastomas
Human Papillomavirus Vaccine - Listeria vaccines containing PEST sequences are adjuvants for HPV16 E7
Human Papillomavirus Vaccine - Plasmid encoding HPV DNA improved immunogenicity against HPV infection
Human Papillomavirus Vaccine - Synthetic HPV16 E7 protein is immunogenic in the TC-1 mouse tumor model
Imaging - Mammographic image analysis method detects, measures changes in breast density
Imaging - Nano-sized probes allow Penn researchers to see tumors through flesh and skin
Information Technology - Texas university's cancer center web site is fourth most visited hospital site
Kaposi Sarcoma-Associated Herpesvirus - Cidofovir used to provide insight into KSHV replication and pathogenesis
Leukemia - Drug fights pre-leukemia condition in two ways
Leukemia - Recent findings in leukemia described
Leukemia - TYK2 appears to be a key regulator of the surveillance of B lymphoid tumors
Liver Cancer - Drug delivery technology shows positive results in liver cancer
Liver Cancer - Hepatitis C virus core protein encoded in hepatocellular carcinomas
Liver Cancer - Researchers report details of new studies and findings in the area of liver cancer
Liver Cancer - Tocotrienol-rich fraction intake may prevent hepatocarcinogenesis
Lung Cancer - CyPA and MIF do not have prognostic value in NSCLC patients
Lymphoma Therapy - Anti-CD20 antibody-drug conjugates show promise for B-cell lymphoma treatment
Malignant Melanoma - FDA grants IND status to malignant melanoma compound
Melanoma - Findings advance knowledge in melanoma research
Melanoma - Proteome of melanoma-derived exosomes characterized
Melanoma - Tissue microarrays used to analyze expression of DNA mismatch-repair genes
Melanoma Vaccine - Cancer antigen heterogeneity in melanoma is methylation-regulated
Multiple Myeloma - Companies advance PXD101 into phase II clinical program
Muscular Dystrophy - Orphan drug designation granted to PTC124 for Duchenne muscular dystrophy
Myeloma - IMF applauds Medicare decision to expand PET scan coverage for myeloma patients
Neuroscience - Recurrent solitary fibrous tumor with cerebrospinal fluid dissemination reported
Neutrophils - Neutrophil GTP-dependent secretion studied, Cdk5 regulation demonstrated
Non-Hodgkin Lymphoma - Injection for non-Hodgkin lymphoma shows promising activity in 2 phase 2 studies
Non-Small Cell Lung Cancer - Company Initiates phase I/II clinical trial of PT-523 in NSCLC
Nutrition - Carrot component reduces cancer risk
Obstetrics - LEEP treatment increases risk of preterm delivery in future pregnancies
Oncogenesis - Findings in oncogenesis provide new insights
Oncogenesis - Recent findings in oncogenesis described
Oncogenesis - Recent findings in oncogenesis provide new insights
Oncology - Endothelin receptor B is a strong regulator of melanoma progression
Oncology - Gelatinase inhibitors warrant scrutiny when used as cancer therapy
Oncology - Inherited gene sequences dictate VEGF activity in non-small cell lung cancer
Oncology - Lamivudine prevents hepatitis B reactivation during breast cancer therapy
Oncology - Microarray discerns DNA changes in microdissected ovarian cancer specimens
Oncology - Percutaneous placement of peritoneal port-catheter safe and effective
Oncology - ROCK inhibitors can block angiogenesis and cancer metastasis
Oncology - Ras oncogene promotes hypoxia-inducible factor-1alpha-related tumor growth
Oncology - Recent studies add new data to oncology research
Oncology - Research in oncology provides new insights
Oncology - Researchers describe findings in oncology studies
Oncology - Researchers report details of new studies and findings in the area of oncology
Oncology - Taxol induces caspase-10-dependent apoptosis
Oncology - Transforming growth factor beta 1 accelerates tumor metastasis
Oncology - VEGF is a target for the management of multiple myeloma
Oral Cancer - Product containing Zila Tolonium Chloride cleared by FDA
Ovarian Cancer - Endometrioid carcinomas have lower MIS rate and PTEN changes than uterine type
Ovarian Cancer - Immunohistochemical expression of cadherin-catenin complex studied
Ovarian Cancer - Lower BMI, more physical activity helps reduce risk in Swedish study
Pancreatic Cancer - Novel radioimmunoconjugate targets metastatic tumor cells
Pancreatic Cancer - Partnership to develop pancreatic cancer therapies announced
Pathology - Sprouting dominates VEGF-induced tumor neovascularization
Pediatric Oncology - BRAF gene hotspot mutations not associated with pediatric solid neoplasms
Personnel - Biopharma company names vice president of process sciences
Personnel - Biotechnology company appoints vice chairman
Personnel - Breast-imaging equipment company names Patti Pavey director of medical education
Personnel - Cancer-focused biopharmaceutical company appoints 2 to development positions
Personnel - Cancer-focused company names Pieter Timmermans senior VP Preclinical Development
Personnel - Clinical research organization announces management changes, new board member
Personnel - Dr. K.C. Nicolaou named as cochairman, scientific advisory board
Personnel - Drug-discovery company appoints top oncologist to advisory board
Personnel - Medical advisory board member named to U.S. National Advisory Eye Council
Personnel - Oncology-focused biopharmaceutical company names James Hawley senior VP
Personnel - Pharma company hires new head of drug development
Personnel - Pharma development company adds members to board of directors
Personnel - Pharmaceutical company adds member to board
Philanthropy - Corporate Express raises more than $65,000 for City of Hope Cancer Center
Philanthropy - Retail shoe company donates $570,000 to breast cancer foundation
Physiology - Inward-rectifier K channels analyzed, conductance determinants clarified
Preventive Medicine - Beans may reduce risk of heart disease, certain cancers
Preventive Medicine - Triedix changes name to reflect baby boomer's demand for preventive healthcare
Prostate Cancer - Biotechnology company to initiate clinical trial for prostate cancer
Prostate Cancer - Fibroblast growth factor 17 over-expressed in prostate cancer
Prostate Cancer - New agents being developed for prostate cancer prevention
Prostate Cancer - Prostate tumor progression may reflect aberrant DNA repair
Prostate Cancer - Recent studies add new data to prostate cancer research
Prostate Cancer - Researchers describe findings in prostate cancer studies
Proteomics - Adenoviral E1A uses the mdm4 protein to stabilize tumor suppressor p53
Proteomics - Endostatin relies on a heparin-binding motif for angiogenesis suppression
Proteomics - Soluble TWEAK protein generates highly vascularized tumors
Receptor Studies - GABA receptor subunit studied, effect of mutation on channel activity revealed
Renal Cell Carcinoma - Endoprosthetic elbow replacement effective as treatment for single metastasis
Retrovirus - Human retroviruses in leukemia and AIDS reviewed
Retrovirus - Murine leukemia virus cleared by flocculation and microfiltration
Small Cell Lung Cancer - Tissue microarrays are not suitable for diagnosis of individual patients
Stem Cell - Therapeutics company announces fast track designation for stem cell product
Stem Cell Research - Rapid elimination of MCs by apoptosis does not lead to significant inflammation
Stem Cell Therapy - Inhibitory NK cell receptor-expressing T cells with CTL activity expanded
Sweet Syndrome - Anti-TNF-alpha antibody effective in patient with refractory disease
Testicular Cancer - Minimum genomic regions of imbalance involved in germ cell tumors determined
Thrombosis - Patients with cancer have highly increased risk for blood clots
Thrombosis - Study compared traits of adolescent thrombosis patients with child patients
Thyroid Microcarcinoma - BRAF(T1796A) transversion prevalent mutational event in thyroid microcarcinoma
Tobacco Use - New York promises stronger anti-smoking campaign
Tobacco Use - No cigar: Cuba launches ban on smoking in public places
Tobacco Use - Poll says Iowa voters favor cigarette tax increase
Transplant Medicine - Circles of DNA might help predict success of stem cell transplantation
Transplant Medicine - Immunology company announces bone marrow transplant trial
Transplant Medicine - New stem cell source could boost bone marrow success
Tumor Suppression - TRAIL inhibits tumor growth but is nontoxic to hepatocytes
Umbilical Cord Blood Transplantation - Cord blood transplant/reduced regimen after ASCT is promising MM treatment
Vaccines Development - New findings in the area of vaccines development detailed
Vaccinia Virus - Modified vaccinia virus Ankara as antigen delivery system reviewed
Vasopressin - Vasopressin and vasotocin receptors studied, critical amino acids identified
Virology - New data illuminates research in virology
Virology - Oncolytic mutant adenovirus destroys solid tumors
Wilms Tumor - Beta-catenin target gene in WT1-mutant Wilms tumor identified
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