Breast Cancer

Enzyme identified that activates cancer cell growth and invasion

Published in Cancer Weekly, March 1st, 2005

Researchers from Tufts-New England Medical Center, Boston, Massachusetts, have identified a long-sought-after enzyme that interacts with a specific protease-activated receptor, PAR1, on breast cancer cells.

The study authors identified metalloprotease-1 as the molecular scissors that activates PAR1, resulting in cancer cell invasion and tumor growth.

They were able to block the spread of the breast cancer in animals using novel compounds called pepducins that act on the inside surface of the cell downstream of the enzyme and receptor. Their study appeared in the February 11, 2005, edition of the journal Cell.

PARs comprise...

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Source: Cancer Weekly (2005-03-01)

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