Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . March 8th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Diagnostics - Gene methylation analysis has potential as tool in cervical cancer screening
Hepatocellular Carcinoma - Clusterin overexpression has prognostic value
Pancreatic Cancer - Novel putative protein biomarkers and therapeutic targets identified
Prostate Cancer - High heterogeneity found in metastatic hormone-resistant disease
Tabacco Use - Genotoxicity of tobacco smoke and tobacco smoke condensate reviewed
Acute Lymphoblastic Leukemia - Role of DNA microarrays in ALL diagnosis and treatment reviewed
Andropause - Company begins phase I clinical trial for its second SARM, ostarine
Angiology - Celecoxib uses multiple signaling mechanisms to suppress neovascularization
Awards - IMF awards Robert A. Kyle Lifetime Achievement Award to Kenneth C. Anderson, MD
Biomedical Engineering - License agreement signed to market, distribute hepatic artery plugging material
Bladder Cancer - Green tea extract has potential as an anticancer agent
Bladder Cancer - New test improves detection of bladder cancer
Bladder Cancer - Panel of tumor markers may improve diagnostic tests
Brain Cancer - Brain tumor victim commutes daily for rehab
Brain Cancer - Nine-year-old boy grateful Frank the tumor is gone
Breast Cancer - Earlier fulvestrant use in heavily pretreated older women may be more effective
Breast Cancer - Findings in breast cancer provide new insights
Breast Cancer - Gene signature can predict metastasis
Breast Cancer - Higher enterolactone levels linked to lower risk of ERalpha-negative cancer
Breast Cancer - Hospital adopts technology for breast cancer diagnosis
Breast Cancer - Hypothyroidism associated with reduced breast cancer risk
Breast Cancer - MTHFR 677TT genotype may confer 40% decreased risk in postmenopausal women
Breast Cancer - Middle-age U.S. women who think their risk is low tend not to get mammograms
Breast Cancer - New findings in the area of breast cancer detailed
Breast Cancer - Recent findings in breast cancer provide new insights
Breast Cancer - Reports describe recent advances in breast cancer research
Breast Cancer - STK15 gene implicated in carcinogenesis
Breast Cancer - Use of standardized patients improves CBEs for U.S. military women
Business & Finance - Biopharma company reports second quarter results
Business & Finance - Company releases financial results, provides summary of R&D efforts
Business & Finance - Cytoskeleton-focused company reports $2.2M Q4 revenues, provides oncology update
Business Update - Biopharma company and EnVivo sign HDAC collaboration agreement
Business Update - Biotech company announces filing of shelf registration statement
Business Update - Cobra extends its agreement to provide long-term manufacture of REOLYSIN
Business Update - Glaxo makes $1.0 million payment, starts phase 2 studies of oral platelet drug
Business Update - Imaging company sells second CT laser mammography system in Italy
Business Update - Infection prevention company's decontamination technology included in report
Business Update - Oncology company moves HQ and R&D operations to San Diego facility
Business Update - Technology company announces new contract for CAD systems for mammography
Cancer Diagnosis - VEGF is not a satisfactory prognostic marker for breast cancer patients
Cancer Epidemiology - New European cancer figures for 2004 reported
Cancer Genetics - BRCA1 mutations estimated to be carried by over half a million U.S. Caucasians
Cancer Genetics - BRCA2, but not BRCA1, mutations account for familial ovarian cancer in Iceland
Cancer Genetics - NMR structure of C-terminal BRCT domain of BRCA1 described
Cancer Genetics - New BRCA1/2 and p53 mutations found in breast cancer patients from India
Cancer Research - Cysteine cathepsins allowed the invasion of AdoMetDC-transformed rodent cells
Cancer Research - Gleevec-resistant gastrointestinal stromal tumors therapy shows positive results
Cancer Research - Trial to study oral spray to reduce chemotherapy-induced nausea
Cancer Therapy - 'T-body' approach may have therapeutic potential in disseminated prostate cancer
Cancer Therapy - BCL-2 inhibition sensitizes malignant cells to cancer immunotherapy
Cancer Therapy - Common virus becomes a new target for cancer treatment
Cancer Therapy - Company to discontinue further development of Pegamotecan
Cancer Therapy - Doxorubicin nano-aggregates stabilized by DOX-PEG-FOL conjugates
Cancer Therapy - EPO induces cancer cell resistance to ionizing radiation and cisplatin
Cancer Therapy - Genomics companies partner to investigate role of cancer genes
Cancer Therapy - Immune system treatment boosts survival from advanced prostate cancer
Cancer Therapy - New data illuminates research in cancer therapy
Cancer Therapy - Normalization windows sensitize cancer cells to therapy
Cancer Therapy - Particle therapy technology to treat tumors to be installed at Heidelberg center
Cancer Therapy - Pharmaceutical company receives PDUFA dates for chemo drug, reports finances
Cancer Therapy - Phase I human clinical trial with 1D09C3 begins
Cancer Therapy - Photodynamic therapy successfully treated feline skin cancer
Cancer Therapy - Recent findings illuminate research in cancer therapy
Cancer Therapy - Researchers describe how tumors acquire resistance to kinase inhibitors
Cancer Therapy - Resveratrol displayed chemopreventive effects
Cancer Therapy - Silibinin limits doxorubicin-induced toxicity in murine tumor models
Cancer Therapy - Washington State cancer center adds image-guided radiation therapy system
Cancer Therapy - ZD6474 arrests the growth of gefitinib-sensitive tumors
Cancer Vaccines - Researchers' work adds to cancer vaccines body of knowledge
Cancer Vaccines - Studies advance knowledge in cancer vaccines research
Cervical Cancer - Partnership will conduct clinical trial of noninvasive cancer detection device
Cervical Cancer - Researchers' findings advance cervical cancer research
Cervical Cancer - Study in Ohio seeks participants for 5-year study about disease incidence
Chronic Liver Disease - The incidence of nonalcoholic steatohepatitis is expected to rise in Japan
Collaborations - Arizona State Univ., Mayo Clinic teaming up on several research projects
Collaborations - Companies sign alliance program for protein kinase target
Colon Cancer - Ritonavir may curb colon carcinogenesis via apoptosis/inflammatory modulation
Colon Cancer - Studies describe new findings in colon cancer research
Colon Cancer Risk Factors - Recreational physical activity lowers risk of colorectal cancer
Colorectal Cancer - Drug company receives U.S. FDA approval for new Eloxatin formulation
Colorectal Cancer - Genetic test helps detect mutations that may be missed by conventional test
Colorectal Cancer - Overexpression of KCNK9 may play role in development
DNA - DNA ligase analyzed, influence of replicative clamp loader revealed
Dendritic Cell Vaccine - Apoptosis of monocytes influences yield of dendritic cells
Dendritic Cell Vaccine - Method to monitor T cells after dendritic cell vaccination developed
Dermatology - Adenovirus-based gene transfer prevents cancer in xeroderma pigmentosum models
Diagnostics - Australian study finds women reluctant to learn BRCA1/2 status
Diagnostics - Stool-based DNA test is preferred over FOBT, colonoscopy for colorectal cancer
Drug Delivery - Pharmaceutical company begins study of lingual spray of antiemetic agent
Drug Development - An oncolytic DNA-alkylating drug for treatment of solid tumors shows promise
Drug Development - Onconase clinical program expanded
Embryogenesis - Mitochondrial SDHD gene required for early embryogenesis
Environmental Health - Tungsten-alloy shrapnel causes tumors, cancer in rats
Enzymology - Y. lipolytica is useful model for studying pathogenic mutations in complex I
Enzymology - KRN633 eliminates angiogenic growth in solid tumors
Enzymology - Proteases mark the survival of node-negative breast cancer
Esophageal Cancer - Esophageal adenocarcinoma cells treated with hemocyanin examined
Exercise - Methods to promote exercise among breast cancer patients outlined
Ezrin-Radixin-Moesin - Ezrin-radixin-moesin studied, role of binding protein clarified
Finance - Biopharmaceutical company reports 4Q, year-end 2004 financial results
Finance - Biotech reports 2004 revenues of $410.4 million
Finance - Biotechnology announces transition quarter financial results
Finance - Imaging company reports "record year of achievements"
Finance - Insurance company contributes to Cancer Treatment Research Foundation
Finance - Oncology-focused biopharmaceutical company reports 4Q, fiscal 2004 results
Finance - Pharmaceutical company announces 2004 financial results
Finance - Small molecule drug discovery company completes public offering of common stock
Finance - Small molecule therapeutics pharmaceutical company announces IPO
Gastric Cancer - Loss of LKB1 function may lead to carcinogenesis of gastric cancer
Gastroenterology - Studies advance knowledge in gastroenterology research
Genomics and Genetics - Molecules that mediate innate immune recognition discovered
Glioma Therapy - Selective estrogen receptor modulators induce glioma cell apoptosis
Gynecology - Atrasentan augments therapies targeting ovarian carcinoma
Gynecology - Endothelin receptor blockade may eliminate COX-2-associated ovarian cancer
HIV/AIDS Diagnostics - Research shows HIV screening is cost effective
HIV/AIDS Prevention - New AIDS organization aimed at black college students
HIV/AIDS Research - HIV LTR-dependent Bax expression selectively induces apoptosis in Tat+ cells
HTLV-1 Infection - Mathematical model studies the dynamics of HIV-1 infection of CD4+ cells
Head and Neck Cancer - Liposomal lurtotecan has limited efficacy in advanced SCCHN
Head and Neck Cancer - U.S. FDA grants orphan drug designation for Proxinium
Health Promotion - Group supports proposal to ban sales of candy-flavored cigarettes
Hepatitis C - Liver-targeted drug delivery article published in journal
Immunology - Dr. Thomas F. Gajewski joins clinical advisory board
Information Technology - National Naval Medical Center selects documentation solution
Kaposi Sarcoma-Associated Herpesvirus - E2-binding C4HC3-type RING domain identified in KSHV K3N-terminal domain
Kaposi Sarcoma-Associated Herpesvirus - New research in the area of kaposi sarcoma-associated herpesvirus detailed
Legal Issues - Montana asbestos victims hope to hold big corporation accountable
Leukemia - A cargo peptide transporter system halts aggressive leukemia and lymphoma
Leukemia - Agreement with U.S. FDA on protocol assessment of leukemia treatment announced
Leukemia - Vaccine may complement conventional treatment for chronic leukemia
Liver Cancer - Ablation success confirmed by pathologic examination
Liver Cancer - Coffee may help prevent liver cancer
Liver Cancer - Nobiletin inhibits hepatocarcinoma cell proliferation in vitro
Liver Cancer - Radiologists offer nonsurgical treatment for early-stage liver cancer
Liver Cancer - Researchers provide details of new studies and findings in the area of liver cancer
Lung Cancer - Blocking estrogen may be crucial to lung cancer survival
Malignant Melanoma - Viragen files to expand cancer approval for Multiferon in Sweden
Medical Training - NCI and FDA announce research, regulatory review fellowship program training
Melanoma - Firefly protein illuminates virus' hunt of metastasized melanoma cells
Melanoma - Microtubule-dependent MMP-2/MMP-9 exocytosis needed for cell invasion
Melanoma Vaccines - Data advance knowledge in melanoma vaccines research
Mergers & Acquisitions - Aptamera's shareholders approve acquisition by Antisoma
Mergers & Acquisitions - Cancer treatment systems company to be acquired by Cytyc Corporation
Mergers & Acquisitions - Cytyc expands women's health presence with acquisition
Mesothelioma - Deaths from asbestos-related lung cancer to peak by 2015
Mesothelioma - Petition urges Congress to fund mesothelioma research
Metastases - Study shows naturally occurring proteins protect against rapid tumor growth
Metastatic Melanoma - Special protocol assessment for trial of metastatic melanoma treatment completed
Mitochondrial Disorder - Elucidating genetic bases of mitochondrial respiratory chain is essential
Murine Mesothelioma - Pharma company begins preclinical study of murine mesothelioma treatment
Neuroblastoma - N-Myc and H-Twist cooperation linked to oncogenesis
Neuroblastoma - PVR expression influences tumor cell susceptibility to NK cells
Neuroscience - VEGF levels rise when peritumoral edema accompanies intracranial meningiomas
Noonan Syndrome - Mouse model of leukemia yields therapeutic implications for rare cancer
Obstetrics - Reports describe recent advances in obstetrics research
Oncology - Antisense molecules targeting alpha folate receptor hinder breast cancer cells
Oncology - Data advance knowledge in oncology research
Oncology - Low platelet counts denote multicentricity in HCV-related liver cancer
Oncology - New data illuminates research in oncology
Oncology - Pro-apoptotic gene therapy destroys prostate cancer
Oncology - Protein with key role in cytokinesis is regulated by p53
Oncology - Recent findings illuminate research in oncology
Oncology - Researchers publish new studies and findings in the area of oncology
Oncology - Studies add new findings to oncology body of knowledge
Oncology - Studies advance knowledge in oncology research
Oncology - Systems biology-tech firm gets U.S. NCI grant for analysis of cancer networks
Oral Cancer - Cyclin G2 dysregulation linked to oral oncogenesis
Ovarian Cancer - Another look finds promising proteomics test is not biologically plausible
Ovarian Cancer - Free online continuing education course for oncology nurses launched
Ovarian Cancer - Murine models of early and late stage disease help evaluate therapeutics
Ovarian Cancer - New findings in the area of ovarian cancer described
Ovarian Cancer - Phase III clinical trial on monoclonal antibody is enrolling patients
Ovarian Cancer - Researchers evaluating new therapy for advanced ovarian cancer
Ovarian Cancer - Serum proteomics technology debated
Ovarian Cancer - U.S. FDA grants approval to ovarian cancer treatment following data submission
Pain Medicine - Study lends insight into management of young patients' symptoms
Pancreatic Cancer - BIA shown as prognostic indicator in pancreatic cancer
Pancreatic Cancer - Pancreatic cancer therapy clinical trial results announced
Pancreatic Cancer - Recent findings in pancreatic cancer provide new insights
Pancreatic Cancer - Safety board gives go-ahead for ongoing trial of pancreatic cancer treatment
Patents - European patent office issues allowance for paclitaxel drug in Europe until 2017
Pediatric Apheresis - Technical risks considered in pediatric apheresis due to size of patient/donor
Personnel - Australian oncology firm announces change in board of directors
Personnel - Biopharmaceutical company adds two virologists to its scientific resource board
Personnel - Biotechnology pharmaceutical company announces two senior management changes
Personnel - Diagnostics company names Michael Silver VP of clinical research
Personnel - Dr. Joseph Rubinfeld resigns from board of Nipent maker
Personnel - Genomics company announces new board member
Personnel - qNPA technology company names two researchers to scientific advisory board
Philanthropy - "The Big Walk" to raise $5M for cancer victims
Promyelocytic Leukemia - Dominant molecular signatures of PML influenced by independent events
Prostate Cancer - IBt announces renewal of European distribution agreement
Prostate Cancer - Inherited gene may increase risk for prostate cancer by 50%
Prostate Cancer - Levels of p27(kip1) modulated prostate cancer progression
Prostate Cancer - Molecular antitumor activity of vitamin D characterized
Prostate Cancer - S100A11 may play role in prostate tumor development
Pulmonary Medicine - Survivin and p53 modulate the influence of quercetin on lung cancer cells
Receptor Studies - VPAC1 , VPAC2 , and PAC1 receptors in human tissues identified
Retinoblastoma - Study demonstrates effectiveness of drug in treatment of retinoblastoma
Severe Acute Respiratory Syndrome - Pharmaceutical company receives SARS vaccine funding
Sexual & Reproductive Health - Lawmakers push for insurance to cover birth control
Stem Cell Research - G-CSF is best cytokine for PBSC mobilization despite efficacy/safety debate
Stem Cell Research - IREM-1 is an inhibitory receptor expressed by myeloid cells
Stem Cell Research - Identifying adult SCs essential for understanding its dynamics during adult life
Stem Cell Transplantation - HLA mismatched SCT based on feto-maternal tolerance alternative to matched donor
Stem Cell Transplantation - Surrogate markers and agents for PBSC mobilization improve collection efficiency
Stem Cells Research - Stem cells may be target cells in development of cancer
Tobacco Use - Impact of low-nitrosamine smokeless tobacco will reflect a variety of factors
Toxicology - Chitosan derivatives staunch genotoxicity
Transplant Medicine - Preoperative prophylaxis aids patients given HBV-related liver transplants
Vaccines Adjuvant - New findings in vaccines adjuvant described
Vaccines Development - New findings in the area of vaccines development described
Virology - Bone marrow transplantation raises the risk for viral reactivation
Virology - Oncolytic adenovirus selects hypoxic tumor cells for destruction
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