Published in Cancer Weekly, March 8th, 2005
The protein Shp2 is required for normal growth factor and cytokine signaling. Mutations in Shp2 cause Noonan syndrome (NS), which is associated with an increased risk of juvenile myelomonocytic leukemia (JMML), and Shp2 mutations have been associated with sporadic JMML as well as other leukemias. Dr. M. Golam Mohi, a...
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