Cancer Weekly

Animal Models - Genetic mouse models of endometriosis and endometrioid ovarian cancer developed

Brain Cancer - Proton magnetic resonance spectroscopic imaging provides pediatric biomarkers

Breast Cancer - New MRI-based imaging method may improve breast cancer detection

Gastric Cancer - Obesity increases risk of gastrointestinal malignancies

Prostate Cancer - Dual targeting of HER-2 and EGFR not recommended

Allergy and Immunology - Local gene therapy can help dendritic cells fight tumor growth

Allergy and Immunology - Thymalfasin shows promise for treating viral hepatitis and cancer

Ascorbic Acid - Vitamin C conjugation is a pathway for elimination of electrophilic LPO products

Assisted Suicide - Terminally ill await Supreme Court's ruling on Oregon's assisted suicide law

B-Cell Lymphoma - Flow cytometry useful for detection of occult CSF involvement

Biomedical Engineering - Interleukin-12 fusion protein and homing peptide eradicate neuroblastoma

Breast Cancer - Studies describe new findings in breast cancer research

Bioterrorism - Company initiates animal studies on compound to treat exposure to terror weapons

Bladder Cancer - Dietary carotenoids and genetic instability modify bladder cancer risk

Bladder Cancer - HER3 and HER4 expression associated with better survival in bladder cancer

Bone Formation Markers - EDA+/EDB+ fibronectin splice variants are markers for bone formation

Brain Cancer - Michigan researcher vies for funding to research brain cancer

Brain Tumor - Treatment for brain tumors granted orphan designation in Japan

Cancer Genetics - Researchers report details of new studies and findings in the area of cancer genetics

Breast & Prostate Cancer - ICAM gene region is breast and prostate cancer susceptibility locus

Breast Cancer - Breast cancer foundation hosted annual conference

Breast Cancer - Candidate genes in breast tumors identified through matrix-CGH analysis

Breast Cancer - Colorado imaging group offers MRI scanning for breast cancer detection

Breast Cancer - Endothelin-1 increases breast tumor perfusion in rats

Breast Cancer - Entities collaborate to analyze DNA samples from breast cancer patients

Leukemia - Recent findings in leukemia provide new insights

Breast Cancer - Estrogen mediates genetic factors associated with breast cancer in female rats

Breast Cancer - Estrogen receptor mutations identified in cancer & psychiatric disease

Breast Cancer - FAK upregulation in ductal carcinoma in situ is early event in tumorigenesis

Breast Cancer - Gene study sheds light on a type of breast cancer

Breast Cancer - Investigator-sponsored phase 1 trial data of breast cancer treatment presented

Breast Cancer - New findings in the area of breast cancer described

Oncology - Reports add new data to oncology research

Breast Cancer - Nucleolar size and activity related to pRb, p53 status in human breast cancer

Breast Cancer - PGE2 from tumor tissue may increase aromatase expression in adipose tissue

Breast Cancer - Polymorphisms in MMP genes can influence breast cancer phenotype

Breast Cancer - Survey finds women will be inconvenienced for noninvasive biopsy procedures

Breast Cancer Risk Factors - Integrin beta(3) Leu33Pro polymorphism may increase breast cancer risk by age 45

Oncology - Reports advance knowledge in oncology research

Breast Cancer Vaccines - Researchers detail new studies and findings in the area of breast cancer vaccines

Business & Finance - Albuferon maker reports increased net loss in 2004, provides clinical update

Business & Finance - DNA-focused biopharmaceutical company announces fourth quarter, year end results

Business Update - ChromaVision Medical Systems to change name

Business Update - Company to expand Cesium-131 production through leased new facility

Business Update - Personalized medicine provider gets CAP accreditation

Oncology - Researchers provide details of new studies and findings in the area of oncology

Business Update - Sales accountability company teams with medical device manufacturer

Cancer Diagnostics - Markers distinguish primary ovarian tumors from metastatic colorectal cancer

Cancer Genetics - Researchers publish new studies and findings in the area of cancer genetics

Cancer Metastasis - Cervical node lesions and inflammatory changes look similar on ultrasound

Cancer Metastasis - Tight junction protein levels decline in metastatic breast cancers

Cancer Prevention - Is it exercise or dieting that helps prevent cancer?

Cancer Risk Factors - Obesity associated with progression of prostate and renal cell cancer

Cancer Screening - Model predicts live-saving benefits of different mammography schedules

Cancer Stem Cells - Cancer stem cells isolated from adult glioblastoma multiforme

Cancer Therapy - Akt activation can promote resistance to microtubule-directed agents

Cancer Therapy - California snail may contain anticancer agent

Cancer Therapy - Caveolin gene delivery diminishes tumor angiogenesis by targeting nitric oxide

Cancer Therapy - FDA accepts Xinlay NDA in treating metastatic hormone-refractory prostate cancer

Cancer Therapy - Liposome-encapsulated lipophilic gemcitabine prodrugs synthesized

Cancer Therapy - Novel breast cancer cell line may aid research on trastuzumab resistance

Cancer Therapy - Phase I/II study initiated for systemic administration of AP 12009

Cancer Therapy - Phase II trials initiated in prostate and bladder cancers

Cancer Therapy - Reports add new data to cancer therapy research

Cancer Therapy - Strategies to disrupt anti-apoptosis protein must overcome major hurdles

Cancer Therapy - Tyrosine kinase inhibitors disrupt malignant mesothelioma growth factors

Cancer Vaccines - Findings advance knowledge in cancer vaccines research

Cardiovascular Disease - There is a potentially profound overlap between CV conditions and cancer

Cell Biology - CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide

Cell Biology - Research reveals insights into how oncogenic protein regulates cell growth

Cell Division - Cell division studied, role of C. elegans MOM-5/Frizzled clarified

Chemotherapy - Most concerns of female cancer patients aren't identified by nurses

Chronic Liver Disease - Protein profiles find cancer markers in patients with chronic liver disease

Chronic Lymphocytic Leukemia - Safety and efficacy of cladribine in CLL treatment clarified

Coccidian Parasite -  C. cayetanensis important parasite in immunocompromised persons

Collaborations - First groundbreaking held in U of California San Diego Science Research Park

Collaborations - Platinum IV compound licensed from M.D. Anderson Cancer Center

Colon Cancer - Age-related ERRP loss in aging colon is potential risk factor for colon cancer

Colon Cancer - Ring finger protein 43 may be novel immunotherapy target

Colon Cancer - Tumor proteins linked to C225 resistance identified

Colorectal Cancer - Patient enrollment completed for HGS-ETR1 phase II trial in colorectal cancer

Coronary Artery Disease - A high percent of CAD/MI population may carry mutations in MEF2A

Cutaneous T Cell Lymphoma - HuMax-CD4 shows encouraging duration of response data in T cell lymphoma

DNA Research - Origin DNA analyzed, binding of molecules revealed

DNA Research - hPot1 studied, role in telomere instability and phenotype revealed

Diagnostics - Arginine-arginine-leucine augments tumor vessel imaging

Diagnostics - Assays used to identify potential treatments for drug-resistant strain of HIV

Diagnostics - Clinical Data signs master distribution agreement for new PSA assay

Diagnostics - Elispot assay optimized to detect cytomegalovirus-specific CD8+ T lymphocytes

Diagnostics - Serum protein profiling identifies patients with gastric cancer

Diagnostics - Test to check for bladder cancer more reliable than cystoscopy, study shows

Diet & Nutrition - Biotech company enters alliance to launch Resurgex and Resurgex-Plus

Diet and Nutrition - Carbohydrate intake not linked to breast cancer incidence in older Danish women

Disease Associations - Interaction of human and mouse Abeta peptides demonstrated

Drug Delivery - Novel norcantharidin microemulsions formulated for parenteral use

Drug Development - Cobalamin-colchicine conjugate shows promise as tumor-targeted cytotoxin

Drug Development - Lipid methotrexate derivative synthesized

Drug Development - Novel retinoic acid metabolism blocking agents have antitumor activity

Drug Development - p73 induction after DNA damage is regulated by Chk1 and Chk2

Emergency Medicine - Ruptured gastrointestinal stromal tumor mimics acute appendicitis

End-of-Life Care - Referrals to palliative care come too late to improve life for cancer patients

Endocrinology - Researchers detail new studies and findings in the area of endocrinology

Environmental Health - Michigan toxic pool has PCB levels 200,000 times above safe levels

Environmental Risk - Report shows diesel exhaust causes 200 early deaths a year in Connecticut

Enzymology - PIWI protein crystals analyzed, siRNA recognition and slicer activity clarified

Epidemiology - Recent studies add new data to epidemiology research

Epidemiology - Water is a major vehicle for Cryptosporidium transmission

Esophageal Cancer - Genes linked to esophageal squamous cell carcinogenesis identified

Finance - Diagnostics company reports quarterly, year-end financial results

Finance - Drug-discovery company raises $45M in private financing

Finance - Grant to support clinical trials of noninvasive cervical cancer detection device

Finance - NAT maker reports strong financial results for Q4 and full-year 2004

Finance - Radiation therapy company reports strong fourth quarter results

Finance - Worldwide Cialis sales top $550 million in 2004

Gene Research - CuraGen exercises option to expand antibody-drug conjugate collaboration

Gene Research - Separating chromosomes may improve genetic test results, study shows

Genotoxicity - Multiple factors contribute to mechanism of particulate matter genotoxicity

Glioma - Drug in trials to treat glioma obtains orphan drug designation in Japan

Gynecology - Adeno-associated virus vector transmits therapeutic ligand to ovarian cancer