Leukemia
AML1-ETO C-terminal NcoR/SMRT-interacting region deletion induces leukemia
Published in Cancer Weekly, March 15th, 2005
According to a study from the United States, "Normal blood-cell differentiation is controlled by regulated gene expression and signal transduction. Transcription deregulation due to chromosomal translocation is a common theme in hematopoietic neoplasms.
"AML1-ETO, which is a fusion protein generated by the 8;21 translocation that is commonly associated with the development of acute myeloid leukemia, fuses the AML1 runx family DNA-binding transcription factor to the ETO corepressor that associates with histone deacetylase complexes."
"Analyses have...
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Source: Cancer Weekly (2005-03-15)
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