Allergy and Immunology

Local gene therapy can help dendritic cells fight tumor growth

Published in Cancer Weekly, March 15th, 2005

Local gene therapy can help dendritic cells fight tumor growth.

"Like paratroopers in special operations, dendritic cells (DCs) can be deployed behind the enemy borders of malignant tissue to ignite an antitumor immune response. 'Cross-priming T cell responses' is the code name for their mission, which consists of taking up antigen from transformed cells or their debris, migrating to lymphoid tissue ferrying the antigenic cargo, and meeting specific T cells," scientists in Spain state.

"This must be accomplished in such an immunogenic manner that specific T lymphocytes would mount a robust enough response as to fully reject the malignancy," according...

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Source: Cancer Weekly (2005-03-15)

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