Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . March 22nd, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Breast Cancer - Imaging system detects cancers missed by mammography
Breast Cancer Vaccine - Killed Mycobacterium vaccae may augment efficacy of trastuzumab
Colon Cancer Risk Factors - Dietary calcium linked to reduced risk of colorectal cancer in women
Gastroenterology - TRAIL gene transfer keeps pancreatic tumors from growing in murine livers
Ovarian Cancer - H-1-NMR-based metabonomics distinguishes patients from healthy controls
Actinic Keratosis - Applying fluorouracil cream before cryosurgery reduces AK lesions, study shows
Age-Related Macular Degeneration - Company expands clinical testing of AdPEDF for wet AMD
Age-Related Macular Degeneration - EVIZON selected as trade name for squalamine in AMD
Allergy and Immunology - Constructs with membrane bound or secreted GITR-L bypass immune suppression
Allergy and Immunology - Small molecule inhibitors suppress nanoparticle-mediated inflammatory response
Alopecia - ETG Mark I receives CE medical mark
Cancer Genetics - Recent findings illuminate research in cancer genetics
Aspergillosis - EIA/qPCR used to diagnose invasive aspergillosis in high-risk patients
Awards - Medical device company wins HCRIC Innovation of the Year awards
B-Cell Lymphoma - TCL1A overexpression linked to poor outcome in DLCL patients
Barrett Carcinogenesis - Cell-cycle phase abnormalities don't account for disordered proliferation
Bone Cancer - Cryosurgery results comparable to those of marginal excision
Bone Marrow Transplantation - Distinct recovery phases of innate cellular-mediated immunity after BMT
Cancer Genetics - Researchers report details of new studies and findings in the area of cancer genetics
Brain Cancer - New findings in the area of brain cancer detailed
Breast Cancer - Aromatase inhibitors may be more effective than antiestrogens for prevention
Breast Cancer - CAD detects small lesions radiologists are likely to miss
Breast Cancer - Cyclin D1 variant seems to reduce effect of hormonal exposure in older women
Breast Cancer - Cytotoxic mechanisms of 15dPG-J2 determined
Breast Cancer - Digital mammography shows lower percent breast density than analog images
Cancer Vaccines - Researchers' data advance cancer vaccines research
Breast Cancer - HER2 DNA delivered by adenoviral vector
Breast Cancer - High serum testosterone levels predict breast cancer recurrence
Breast Cancer - Higher cancer rates likely to accompany westernization of Singaporean lifestyle
Breast Cancer - IGF-I gene polymorphisms may be risk factor in Chinese women
Breast Cancer - Increasing physician volume requirement could improve mammogram accuracy
Breast Cancer - Intervention helps women treated for cancer make major dietary changes
Cancer Vaccines - Researchers' work adds to cancer vaccines body of knowledge
Breast Cancer - Low serum HDL-C may be biomarker of cancer risk in overweight and obese women
Breast Cancer - MRI better than current standard in assessing neoadjuvant chemotherapy
Breast Cancer - MRI useful for assessing patients with suspected cancer
Breast Cancer - Masking of erbB2 may underlie Herceptin resistance
Breast Cancer - Older women can benefit from chemotherapy
Breast Cancer - Peptide assay variability in IGF-I-based risk estimates compared
Oncology - Researchers describe findings in oncology studies
Breast Cancer - Positron emission mammography device detects small lesions
Breast Cancer - Recent findings in breast cancer described
Breast Cancer - Short course of hCG may have chemoprotective potential
Breast Cancer - U.S. FDA clears MammoReport(Plus) for extended use
Breast Cancer - Urinary estrogen metabolite ratio may signal higher risk in Asian Americans
Breast Cancer Risk Factors - Risk factors differ by age, race among African American and white women
Oncology - Researchers' findings advance oncology research
Breast Cancer Vaccine - Anti-HER2 antibodies block HER2 phosphorylation and signaling
Business & Finance - Diagnostics/lab service company reports dip in revenue, changes name
Business & Finance - Drug discovery company announces financial results
Business & Finance - Research company reports preliminary fourth quarter and year-end results
Business Update - Biopharma company signs agreement with Celliance BioServices, Inc.
Business Update - Company updates PAR-2 program in oncology and inflammation
Business Update - Consulting company reports Medicare reform changing oncology practices
Business Update - Gene therapy company reports progress of avian transgenic biomanufacturing
Business Update - Pennsylvania center granted recertification by American College of Surgeons
Business Update - Pharma company engages WorldCare Clinical for diagnostic services
Cancer Diagnostics - Diagnostic products company files IND for biopsy product
Cancer Genetics - New data illuminates research in cancer genetics
Cancer Prevention - L-carnitine prevents liver cancer formation in laboratory models
Cancer Research - Reolysin clinical trial approved by U.K. regulatory authorities
Cancer Therapy - Antagonists to melanoma-inhibiting activity foil immunosuppression
Cancer Therapy - Chemists synthesize molecule that helps body battle cancers, malaria
Cancer Therapy - Evotec OAI to provide process validation for phase III compound, AMD 3100
Cancer Therapy - Findings advance knowledge in cancer therapy research
Cancer Therapy - Novel sensor chips enable analysis of drug effects on tumor cell metabolism
Cancer Therapy - Study shows patients get more benefit than thought from early cancer treatment
Cancer Therapy - Toll-like receptor 9 agonist enhances antitumor activity of Cetuximab, data show
Cancer Vaccines - Amino acid substitution improves enzymatic stability of MUC2 epitope
Cancer Vaccines - B-lymphocytes activated by CD40 ligand induce anti-tumor response
Cancer Vaccines - Distinct overlapping T helper epitopes found in 37-58 region of SSX-2
Cancer Vaccines - Findings describe new data in cancer vaccines research
Cancer Vaccines - IL-12-secreting dendritic cells generate anti-tumor immunity in mice
Cancer Vaccines - Immunotherapy for malignant gliomas reviewed
Cancer Vaccines - Multi-epitope vaccines elicit CD8+ cytotoxic T cells
Cancer Vaccines - PLGA microspheres improve antigen delivery to dendritic cells
Cancer Vaccines - TP-3 immunotoxins improve antitumor activity in mice with osteosarcoma
Cancer Virology - New binding target for oncogenic viral protein revealed
Cell Biology - Mitotic checkpoint protein BubR1 regulates chromosome-spindle attachment
Cell Proliferation - Cell migration inhbited, nature of MEK1-mediated restoration clarified
Cervical Cancer - Collaboration will focus on topical anti-HPV treatment
Cervical Cancer - IFN gamma gene variant is associated with individual disease susceptibility
Cervical Cancer - Researchers' work adds to cervical cancer body of knowledge
Chromosome Structure - Mammalian protein SCP1 studied, synaptonemal complex-like structures revealed
Clinical Trials - Biopharmaceutical company receives payment, moves antibody into clinical trials
Clinical Trials - Drug company to focus on developing cancer and infectious diseases products
Collaborations - Pharmaceutical companies enter biogeneric partnership
Colon Cancer - Duke develops new breed of viral vaccines to battle colon cancer
Colon Cancer - Extracellular enzymes predict the outcome of colorectal cancer
Colon Cancer - Nondegraded total RNA extracted from colonocytes from normal/malignant tissue
Colon Cancer - Oral chemotherapy gets positive EU review for colon cancer after surgery
Colon Cancer - Osteopontin promotes tumor progression in multiple ways
Colon Cancer - Soybean saponins can induce macroautophagy in colon tumor cells
Colon Cancer Screening - Men braver than women over bowel cancer test
Colorectal Cancer - Noninvasive early stage colorectal cancer diagnostic test being developed
Colorectal Cancer - Novel purification method improves DNA yield from stool
Colorectal Cancer - Research company awarded grant to study DNA mutations in colorectal cancer
Colorectal Carcinoma - Microsatellite-stable, near-diploid bowel tumors characterized with array-CGH
Complementary & Alternative Medicine - Ursodiol may prevent cancer in those with hepatitis C-linked liver cirrhosis
Congenital Heart Disease - ENU-induced mutations may yield insights into genetic basis of CHD
Cystic Fibrosis - Therapeutic company receives $1.7 million award from cystic fibrosis foundation
Cytomegalovirus Vaccine - Methods to enumerate antigen-specific T-cell responses compared
Disease Associations - Bone density not related to breast density or risk of breast cancer
Disease Associations - Effects of cigarette smoke studied, physiological inhibitions revealed
Disease Associations - Leukocyte heat-shock induction studied, role of electromagnetic fields clarified
Disease Prevention - An apple a day can help keep breast cancer away, suggests rat study
Drug Development - Modified heparin antagonizes angiogenesis without affecting coagulation
Drug Development - Pharmaceutical company files ANDA with U.S. FDA for opthalmic product
Drug Development - Somatostatin agonists may control tumor neovascularization
Electronic Medical Records - IT company makes mammography repository available on line directly to women
Endometrial Cancer - MIS inhibits proliferation of cell lines expressing MIS type II receptor
Endometrial Cancer Risk Factors - Tamoxifen use past 5 years is associated with increased endometrial cancer risk
Endometrial Carcinoma - Tissue microarray used to identify cancer-testis antigens
Environmental Health - Passive smoking kills 30 people a day in the U.K.
Enzymology - Cyclooxygenase-2 inhibition has a selective effect on endothelial cell growth
Enzymology - Matrix metalloproteinase inhibitor MMI270 helps chemotherapy fight metastasis
Esophageal Cancer - Premature birth significantly increases risk of GI cancer
Finance - Biotechnology company reports 2004 annual financial results
Finance - COLD-EEZE manufacturer reports financial results
Finance - Cancer-focused bioscience company reports 2004 Q4 and year-end financial results
Finance - Cancer-focused pharmaceutical company reports Q4, full year 2004 results
Finance - Company attributes much of Q2's income drop to decline in ABELCET sales
Finance - Company's Q4 and year-end results affected by X-Ceptor Therapeutics acquisition
Finance - Developer, manufacturer of human cell lines reports 2004 results
Finance - HIF-focused company completes equity financing
Finance - Infection- and cancer-focused company reports year end 2004 financial results
Finance - Pharma company announces record financial results
Finance - Pharma company releases financial results showing increase in net income
Finance - Pharmaceutical company receives $750,000 equity investment
Finance - Spinoff company Ceptor Corp. completes private offering, becomes independent
Finance - Vaccine-focused biopharmaceutical company announces FY 2004 financial results
Fungal Therapy - Profile of an ideal antifungal presented
Gastroenterology - Hepatitis C virus core protein alters liver cells differentially
Gastrointestinal Cancer - Overweight women with esophageal and stomach cancer survive longer
Gene Research - Circulating blood endothelial cells mark the efforts of antiangiogenic drugs
Gene Research - Controlled conditions allow laboratories to conduct collaborative gene studies
Gene Sequencing - NCI creates gene expression database of normal human organ tissue
Gene Transfer - New data illuminates research in gene transfer
Grants - Cancer foundation sees 25% increase in grant applications, will pick 15 scholars
Growth Factor Receptors - Fibroblast receptor studied, role of a novel intronic cis element clarified
Gynecologic Cancer - Researchers suggest chlamydial HSP60 may be risk factor for oncogenesis
Gynecology - Molecular markers indicate the presence of cervical cancer
Gynecology - Researchers describe findings in gynecology studies
HIV/AIDS-Associated Infection - Severe respiratory disease necessitating hospitalization decreased in HAART era
Head and Neck Cancer - Antisense down-regulation of metallothionein-2A limits nasopharyngeal cancer
Healthcare Access - Cancer center developer changes name to Aptium Oncology
Healthcare Access - Women in poor neighborhoods tend to get late-stage cancer diagnosis
Healthcare Fraud - Doctor indicted again on healthcare fraud charges
Hematology - Immature dendritic cells help CD40 ligand regress established myeloma
Hematopoiesis - C/EBPalpha is essential for granulocyte development/regulates HSC activity
Hematopoiesis - NF-kappaB prevents apoptosis at multiple steps of hematopoiesis by removing ROS
Hodgkin Lymphoma - Chk2 expression may be downregulated in HL cells via epigenetic mechanisms
Hospice - Forgoing of end-of-life treatment varies in European countries
Human Herpesvirus 6 - Article examining Human Herpesvirus 6 published in leading journal
Human Papillomavirus - Prevalence of human papillomavirus genotypes in women reported
Human Papillomavirus Vaccine - Human papillomavirus oncoprotein vaccine eradicates established tumors
Imaging - Technology company receives approval to expand use of ImageChecker D product
Influenza Vaccine - Guide for flu and pneumococcal vaccines in cancer patients released
Kaposi Sarcoma-Associated Herpesvirus - New research in the area of kaposi sarcoma-associated herpesvirus detailed
Licensing - Pharmaceutical firm acquires license to endothelinB agonists for chemo delivery
Liver Cancer - MRI suitable for assessment of internal radiation therapy
Liver Cancer - Nanotech company researcher explains clinical trials for liver cancer treatment
Lung Cancer - Mutated genes involved in lung cancer; one affects nonsmokers
Lung Cancer - Researchers learn why some lung cancers stop responding to erlotinib, gefitinib
Malaria - Biotechnology corporation initiates pediatric antimalaria trial
Malaria Diagnostics - Diagnostics company developes rapid test kit for malaria, expands TB testing
Malignant Mesothelioma - Mesothelial marker D2-40 may be useful in differential diagnosis
Mammography Diagnostics - Mammography screening nonattenders in Denmark don't seek screening elsewhere
Melanoma - Doctors use sound to battle skin cancer
Melanoma - Origins of MDA-MB-435 cells with melanoma genes clarified
Melanoma Vaccine - MAGE-A3 is a frequent tumor antigen of metastasized melanoma
Melanoma Vaccine - Peptide vaccine has minimal benefit in patients with stage IV melanoma
Melanoma Vaccine - Vaccine induces T cell response against tumor antigen survivin
Melanoma Vaccines - Findings advance knowledge in melanoma vaccines research
Mergers & Acquisitions - Pharma company to acquire Idun Pharmaceuticals
Mutagenesis - Enterococcus faecalis lsa locus studied, differences clarified
Myeloma - "Smart" immune cells kill more cancer
Nanotechnology - Industry consultancy releases two white papers on nanotechnology
Non-Hodgkin Lymphoma - Enrollment, initial dosing completed in HGS-ETR1 trial in non-Hodgkin lymphoma
Non-Hodgkin Lymphoma - Yttrium 90 ibritumomab tiuxetan does not impair subsequent treatment
Non-Small Cell Lung Cancer - Female sex is independent positive predictor of long-term postsurgery survival
Non-Small Cell Lung Cancer - Gene profiling can predict gefitinib susceptibility of NSCLC cells
Oncogenesis - Negative LMO2 gene regulatory elements may produce its appearance in leukemia
Oncology - Antiangiogenic gene therapy may be a valuable adjuvant for chemotherapy
Oncology - Antiangiogenic genes prevent secondary metastasis after primary tumor removal
Oncology - CXCR4 knockdown slows breast tumor growth and invasion
Oncology - Gene silencing sensitizes prostate cancer to cancer therapy
Oncology - Genes commonly overexpressed in solid tumors identified
Oncology - Immunocompetent breast cancer models test Eph receptor-targeted therapy
Oncology - Mendelian tumor syndrome lesions possess increased microvessel density
Oncology - Orally administered bacteria transport anticancer genes in mice
Oncology - Protein antagonists reduce the metastatic potential of melanoma
Oncology - Recent findings illuminate research in oncology
Oncology - Research: Chemically induced breast cancers can be stopped by nutrients
Oncology - Small study finds total laparoscopic hysterectomy safe for morbidly obese women
Oncology - Utility of cancer screening tests reviewed
Oncology - Virally mediated Skp-2 RNA interference cuts cancer growth
Osteosarcoma - Gene amplifications identified through CGH microarray analysis
Ovarian Cancer - ApoE required for cell proliferation, survival in apoE-expressing cancer cells
Ovarian Cancer - Class III beta-tubulin overexpression a key mechanism of paclitaxel resistance
Ovarian Cancer - Intraperitoneal continuous hyperthermic chemotherapy is promising
Ovarian Cancer - New medicine may help patients with advanced ovarian cancer
Pain Management - New patch for treatment of chronic pain launched
Pancreatic Cancer - New mother dies of cancer that she never knew she had
Pancreatic Cancer - U.S. FDA clears randomized portion of phase II TNFerade in pancreatic cancer
Patents - Company files for patents on cancer genes
Patents - Pharma company announces new patents
Patents - Technology company granted artificial liver device patent
Patents - U.S. patent granted for cyclin dependent kinase inhibitor series
Peptide Elongation Factors - Proteasome-mediated protein degradation studied, elongation factor revealed
Personnel - Christopher S. Henney invited to join board of cancer management company
Personnel - Device maker names Eric S. Kentor to board of directors
Personnel - Immunotherapeutics company appoints board chairman
Personnel - Nevada cancer institute names VP of communications and public affairs
Pharmaceutical Research - Study focusing on EU pharma and biotech growth opportunities released
Pharmaceutical Research - U of Maryland faculty awarded $3.2 million to develop technology products
Philanthropy - Genomics-focused biomedical company foundation announces new charitable fund
Philanthropy - Kleberg Foundation gives $5 million to M.D. Anderson for molecular marker center
Platelets - Enhanced platelet activation occurs in colorectal cancer patients
Product Licensing - Pharma company licenses novel anticancer compounds
Prostate Cancer - 3alpha-diol stimulates prostate cell proliferation via EGF-like pathway
Prostate Cancer - Analysis shows drug could save men's lives
Prostate Cancer - CB7630 phase I clinical data presented at prostate cancer meeting
Prostate Cancer - Celecoxib provides double prostate cancer cell proliferation
Prostate Cancer - Immune-based therapies for prostate cancer reviewed
Prostate Cancer - Pharmaceutical company announces results of prostate cancer clinical trial
Prostate Cancer - Provenge/Avastin combo increases PSADT
Prostate Cancer - U.S. FDA approves new device for diagnosing and treating prostate cancer
Prostate Cancer Therapy - Phosphoglycerate mutase B is molecular target of resveratrol
Prostate Cancer Vaccines - Researchers' findings advance prostate cancer vaccines research
Protein Signals - Caenorhabditis elegans DAZ-1 studied, roles during oogenesis clarified
Proteomics - Angiogenin is essential for endothelial cell proliferation and angiogenesis
Proteomics - Recent findings in proteomics provide new insights
Psoriasis - Research company reports efficacy and safety results of psoriasis treatment
Renal Cell Carcinoma - Expression of Kank in RCC characterized
Reproductive Medicine - Ovarian reserve testing in cancer patients needs more study for clinical use
Resveratrol - Resveratrol's cancer prevention may result from changes in cell cycle progress
Skin Cancer - Recent studies add new data to skin cancer research
Stem Cell Research - Not all leukemic oncogenes transform committed SCs lacking self-renewal capacity
Stem Cell Transplantation - Alternate hemibody irradiation + HD chemotherapy treats hematological malignancy
Stem Cell Transplantation - Five-year survival >80% after HSCT with matched unrelated donors
Stem Cell Transplantation - Reconstitution of CMV-specific CD8+ T cells delayed after SCT
Stem Cells - Study finds hematopoietic stem cells depend on a single protein Mcl-1
Stroke - MTHFR allele evaluation will help prevent/reduce morbidity caused by stroke
Surgical Technology - Health system adds radiosurgery technology
Testicular Cancer - Research is first step toward noninvasive test for testicular cancer
Tissue Engineering - Organoid culture in elliptic hollow fibers develops hybrid artificial liver
Tobacco Use - At least two central Nebraska hospitals to ban smoking on grounds
Tobacco Use - E.U. launches anti-smoking campaign targeted at young
Tobacco Use - First global anti-smoking treaty becomes binding international law
Tobacco Use - Mississippi coalition urges lawmakers to revive cigarette tax bill
Transcriptional Repressors - E2F6 complex analyzed, proliferation-specific EZH2 interaction shown
Umbilical Cord Blood Transplantation - CBT treats case of EBV-related lymphoproliferative disease
Vaccine Development - Clinical-stage pharma reports on anticancer progress at angiogenesis symposium
Vaccine Development - Toll-like receptors induce antigen cross-presentation
Virology - Research add new data to virology body of knowledge
X Inactivation - X inactivation studied, boundaries between chromosomal domains clarified
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