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Endometrial Carcinoma

Tissue microarray used to identify cancer-testis antigens

Published in Cancer Weekly, March 22nd, 2005

Tissue microarray analysis has been used to identify several cancer-testis (CT) antigens in endometrial carcinoma.

CT antigens "are expressed in a variety of malignant tumors, but in normal adult tissue, they are only expressed in testicular germ cells," pathologists in New York explained. "Owing to this tumor-associated expression pattern, these antigens are of major interest as potential targets for immunotherapy and possibly for diagnostic purposes."

With this in mind, D.A. Chitale and colleagues at the Memorial Sloan-Kettering Cancer Center conducted a study "to analyze the expression of four CT antigens, NY-ESO-1, MAGE-A3, MAGE-A4, and...

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