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Gene Sequencing

NCI creates gene expression database of normal human organ tissue

Published in Cancer Weekly, March 22nd, 2005

Researchers at the National Cancer Institute (NCI), part of the U.S. National Institutes of Health (NIH), have built the largest open-source database for normal tissue from human organs.

Scientists searching for genes that go awry and cause disease can use the NCI database as a crucial point of reference because it pinpoints which genes are expressed in many of the body's major organs under normal conditions (without known disease). Scientists can compare the genes from their own biological samples to this dictionary of normal expression.

"Genes identified by the database as abnormally active in a particular disease could become potential targets,...

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