Hematopoiesis
C/EBPalpha is essential for granulocyte development/regulates HSC activity
Published in Cancer Weekly, March 22nd, 2005
According to recently published research from the United States, "The transcription factor C/EBPalpha is required for granulopoiesis and frequently disrupted in human acute myeloid leukemia (AML).
"Here, we show disruption of C/EBPalpha blocks the transition from the common myeloid to the granulocyte/monocyte progenitor but is not required beyond this stage for terminal granulocyte maturation."
"C/EBPalpha-deficient hematopoietic stem cells (HSCs) have increased expression of Bmi-1 and enhanced competitive repopulating...
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Source: Cancer Weekly (2005-03-22)
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