Cell Biology
Mitotic checkpoint protein BubR1 regulates chromosome-spindle attachment
Published in Cancer Weekly, March 22nd, 2005
"Loss or gain of whole chromosomes, the form of chromosomal instability (CIN) most commonly associated with human cancers, is expected to arise from the failure to accurately segregate chromosomes in mitosis," scientists in New York explained. "The mitotic checkpoint is one pathway that prevents segregation errors by blocking the onset of anaphase until all chromosomes make proper attachments to the spindle."
"Another process that prevents errors is stabilization and destabilization of connections between chromosomes and spindle microtubules," noted M.A. Lampson and...
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Source: Cancer Weekly (2005-03-22)
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