Cancer Weekly

Bladder Cancer - Polymorphism in NF-kappa B binding site linked to higher risk of bladder cancer

Breast Cancer - Compound inhibits critical pathway in breast cancer growth

Breast Cancer - Racial differences in CYP3A5 polymorphisms don't affect tamoxifen metabolism

Colon Cancer - CCSP-2 found to be a novel serological marker of colon neoplasia

Kidney Cancer - No prognostic advantage in quantifying apoptosis factors in Wilms tumors

Abdominal Cancer - Imaging of abdominal cancer lesions facilitated by Tc-99m-bombesin analogue

Acute Lymphoblastic Leukemia - Gene expression profiles can predict molecular treatment response

Acute Lymphoblastic Leukemia - Genomic response to L-asparaginase characterized in ALL cells

Acute Myeloid Leukemia - SU11248 produces short-term partial remissions in leukemia patients

Adverse Drug Reaction - Endometrial responses to SERMS investigated

Adverse Drug Reaction - Rituximab-based chemotherapy may reactivate hepatitis B virus infection

Cancer Vaccines - Researchers' findings advance cancer vaccines research

Age-Related Macular Degeneration - New treatment for wet age-related macular degeneration

Angiogenesis - Pharma company initiates phase II clinical study of lung cancer treatment

Anthracycline - Study tested cell-growth inhibitory effects of anthracyclines

Antitumor Drug - Peptidyl derivatives have antitumor activity

Arsenic Exposure - Eliminating arsenic in drinking water decreased lung cancer mortality in Taiwan

Basal Cell Cancer - PTCH polymorphism mediates susceptibility to basal cell carcinoma

Endocrinology - New research in the area of endocrinology detailed

Bioinformatics - Computer models predict the effects of vessel maturation on tumor dynamics

Black Tea - Black tea intake does not modulate mutagen excretion from ingested beef

Bladder Cancer - Relative copy number of bladder cancer genes determined by real-time PCR

Bone Cancer - Zoledronic acid recommended as treatment for patients with bone metastases

Bone Marrow Disorders - Functional mechanisms of myelodysplastic syndrome studied

Bone Marrow Disorders - Modulation of drug resistance transporters as key strategy for treating MDS

Oncology - Findings advance knowledge in oncology research

Bone Marrow Transplantation - Competing risks approach estimates primary/secondary relapse following ABMT

Brain Cancer - Biopharmaceutical company initiates phase 1 trial in metastatic brain cancer

Breast Cancer - Breast cancer patients can boost quality of life by using vaginal moisturizer

Breast Cancer - Breast cancer resistance protein gene expression modulated using siRNAs

Breast Cancer - CAT study to examine combination hormonal therapy for advanced breast cancer

Breast Cancer - Case-mix failed to explain variation in mastectomy rates

Oncology - Findings in oncology provide new insights

Breast Cancer - Digital mammography system showcased at national breast centers consortium

Breast Cancer - EGCG functioned as anticarcinogen against ER-negative breast cancer cells

Breast Cancer - ERCC2 genotypes and corresponding haplotype linked with breast cancer risk

Breast Cancer - Gene expression characterized in microscopically isolated tumor cells

Breast Cancer - HER-2/neu overexpression decreases wild-type p53 via activating PI3K pathway

Breast Cancer - Mammography data now available to patients through Patient Portability Program

Oncology - Recent studies add new data to oncology research

Breast Cancer - Montana women pose for breast cancer calendar

Breast Cancer - Neulasta trial results published in The Journal of Clinical Oncology

Breast Cancer - Non-invasive and invasive breast cancers share same BRCA1/2 mutations

Breast Cancer - Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing

Breast Cancer - Positive Abraxane survival data presented

Breast Cancer - Preoperative low serum MMP-9 increases 10-year relapse risk

Oncology - Research add new data to oncology body of knowledge

Breast Cancer - Progress reported in vaccine development

Breast Cancer - Study discusses keys to increasing testing accuracy in breast cancer

Breast Cancer - Study: Chemicals in apples could reduce the risk of breast cancer

Breast Cancer - Ultrasound-guided LCNB of breast lesions for reliable tumor classification

Breast Cancer - XPD polymorphism increases breast cancer risk from PAH-DNA adducts/cigarettes

Breast Cancer Therapy - Role of PI3-AKT signaling in genomic effects of trastuzumab determined

Oncology - Researchers detail new studies and findings in the area of oncology

Business & Finance - Pharmaceutical company reports fourth quarter results, clinical progress

Business Update - Distributor reports strong progress in its specialty drug-distribution strategy

Business Update - GPC Biotech acquires assets of kinase drug-discovery firm

Business Update - GenPath Pharmaceuticals changes name

Cancer Diagnostics - FDA does not recommend approval of the proposed indication for Combidex

Cancer Genetics - Reports add new data to cancer genetics research

Oncology - Researchers report details of new studies and findings in the area of oncology

Cancer Immunotherapy - Lymphocyte contamination makes genetically altered dendritic cells disappear

Cancer Prevention - Designing the selenium and vitamin E cancer prevention trial (SELECT)

Cancer Research - 'Promising' in vivo data on kinase anti-cancer small molecule program presented

Cancer Research - Biopharmaceutical company discovers role of Ero-1L alpha gene

Cancer Research - Pharmaceutical company begins clinical development of OSI-930

Cancer Research - Pharmaceutical company reports transfer of orphan drug status for oncology drugs

Proteomics - Recent findings in proteomics described

Cancer Risk - Association between HIV/AIDS and cancer risk assessed in southeast England

Cancer Risk - Opium smoking associated with elevated carcinoembryonic antigen levels

Cancer Risk Factors - Risk of gastrointestinal cancer with obesity reviewed

Cancer Therapy - Alliance established for trial of non-small cell lung cancer vaccine

Cancer Therapy - Brain tumor can be cured in older kids using radiation, chemotherapy

Cancer Therapy - Combining external radiotherapy and anemia treatment endorsed

Cancer Therapy - Company announces strategic alliance to develop new cancer therapies

Cancer Therapy - Efficacy of irinotecan and capecitabine as second-line treatment revealed

Cancer Therapy - Efficacy of warfarin in cancer patients inferior to LMW heparin

Cancer Therapy - Eligard now available for treatment of prostate cancer

Cancer Therapy - Experimental cancer treatments help

Cancer Therapy - First patient treated in phase I trial of ThermoDox with heat for liver cancer

Cancer Therapy - From discovery to clinical development of thymidylate synthase inhibitor ZD9331

Cancer Therapy - Genes and pathways associated with oxaliplatin resistance identified

Cancer Therapy - H-Ras oncogene counteracted growth-inhibitory effect of genistein in T24 cells

Cancer Therapy - Histone deacetylase inhibitors showed promise as novel cancer therapeutic agents

Cancer Therapy - Inherited traits, tumor mutations affect response to Treatment of ALL

Cancer Therapy - Intravenous administration of the SMA-THP enhanced effect of pirarubicin

Cancer Therapy - Mean survival time doubles in patients with pancreatic cancer using RP101

Cancer Therapy - NAC blocks cisplatin-induced apoptosis through caspase signaling pathway

Cancer Therapy - Natural killer cell cytotoxicity could sculpture myeloma

Cancer Therapy - New treatments for difficult cancers improve survival, quality of life

Cancer Therapy - Nuclear reactor employed as a cancer cure

Cancer Therapy - Peptides targeting VEGF limit its autocrine and paracrine functions

Cancer Therapy - Phase I/II study of Amplimexon plus gemcitabine initiated

Cancer Therapy - Polymeric micelle drug carriers showed promise in cancer therapy

Cancer Therapy - Positive trial data presented on anticancer compound, Quinamed

Cancer Therapy - Power Doppler sonography useful in diagnosis of TIVAP catheter leakage

Cancer Therapy - Research add new data to cancer therapy body of knowledge

Cancer Therapy - Taxol- and dEpoB-induced signaling activities compared

Cancer Therapy - Telomerase promoter enhances the efficacy of lung cancer suicide gene therapy

Cancer Therapy - Thioredoxin inhibitor AW464 hammers tumor growth under hypoxic conditions

Cancer Therapy - Vaccine adjuvant shows enhanced immune response in prostate cancer patients

Cancer Therapy - Vinorelbine showed no clinical influence on patients with metastatic melanoma

Cancer Vaccines - Branched lysine peptide has antitumor effect in rat glioma model

Cancer Vaccines - Dendritic cell vaccine elicits long-lasting protective tumor immunity

Cancer Vaccines - Dendritic cells have limited potential in immunotherapy

Cancer Vaccines - Dendritic cells modulate antitumor responses

Cancer Vaccines - HLA-DR beta1*0101- and 1*0401-restricted epitopes identified

Cancer Vaccines - Highly specific overexpression of SOX11 occurs in malignant gliomas

Cancer Vaccines - Human tumor antigens recognized by T cells listed

Cancer Vaccines - New findings in cancer vaccines described

Cancer Vaccines - Peptide with native disulfide bonds enhances antitumor activity

Cancer Vaccines - Peptides from taxol resistance-related protein elicit T-cell responses

Cancer Vaccines - Virosomes for antigen and DNA delivery reviewed

Carcinogens - Carcinogenicity of dioxin-like compound mixture is dose additive

Cervical Cancer - Adenocarcinoma rate up, squamous cell cancer down among young Dutch women

Cervical Cancer - Cost effectiveness of four management strategies for ASCUS compared

Cervical Cancer - MTHFR, MS variants in folate metabolic pathway linked to reduced CIN 2/3 risk

Cervical Cancer - Study finds HPV DNA detectable in blood only in advanced cases

Cervical Cancer - Value of adding HPV types to screening and triage tests is questioned

Cervical Cancer - Women need better understanding of HPV testing

Clinical Trials - Company completes enrollment of immune recovery drug in phase I clinical trial

Clostridium Infection - Patients with C. difficile-related diarrhea have higher mortality

Collaborations - Companies announce strategic alliance for ThinPrep Imaging System

Collaborations - Grant Life Sciences announces collaboration with Cleveland Clinic subsidiary

Collaborations - Research collaboration to analyze diabetes, breast cancer genetic markers

Colon Cancer - Avastin proven effective in advanced colorectal cancer patients

Colon Cancer - Serum cathepsin H potential prognostic marker in patients with colorectal cancer

Colorectal Adenocarcinoma - Mortalin overexpression linked to high mortality risk

Colorectal Cancer - Culturelle may prevent lesions that can lead to some forms of colon cancer

Colorectal Cancer - Endothelin-1 contributes to colon cancer tumorigenesis

Colorectal Cancer - Hereditary cancer expert links colorectal cancer and Jewish people

Colorectal Cancer - MTHFR 677 TT and MTR 2756 GG genotypes confer reduced colorectal cancer risk

Colorectal Cancer - Pharma company engages WorldCare Clinical diagnostics services

Colorectal Cancer - Second most fatal cancer sometimes inherited

Complementary & Alternative Medicine - Mega doses of green tea extract may help, not hinder, tumor growth

DNA Damage - TDP1 overexpression counteracts DNA damage mediated by topoisomerases I and II

Dermatology - Gene patterns distinguish desmoplastic melanoma from non-desmoplastic melanoma

Dermatology - New findings in the area of dermatology detailed

Dermatology - Therapies that regulate heparanase can control malignant melanoma

Diagnostics - Ac-LDL uptake and CD16 segregate tumor macrophages from endothelial cells

Diagnostics - Glycoproteomic analysis discovers markers for early HBV-related liver cancer

Diagnostics - Kindred Healthcare to install a dozen CT systems in acute care hospitals

Diagnostics - Prognostic factor for newly diagnosed metastatic breast cancer published

Diagnostics - U.K. distributor awarded 5-year contract to supply liquid-based pap test

Diet & Nutrition - Laboratory introduces dietary supplement for men to promote prostate health

Disease Associations - Epigenetic regulation of gene expression studied, critical roles established

Disease Associations - Steep rise of IL-6 associated with late stages of cachexia in cancer patients

Disease Associations - Therapy recommendations made for hypercalcemia and childhood cancer

Drug Development - Anti-FAPP monoclonal antibody inhibits pancreatic tumor growth in mice

Drug Development - Aplidin commences phase II clinical trials in prostate and bladder cancers

Drug Development - CD33 expression influences gemtuzumab ozogamicin-based toxicity

Drug Development - Data on cellular progression of chronic lymphocytic leukemia published

Drug Development - Partner pharma companies announce compound development nomination

Drug Development - Results to be reported from STELLAR 3 trial of Xyotax

Drug Development - Successful results reported in phase II trial of Teverelix in prostate cancer

Drug Development - Thiocolchicine dimers active against cisplatin-resistant ovarian tumor cells

Drug Discovery - Scientists solve 3-D structures of PCNA complexes

Drug Resistance - Research may provide ways to inhibit cancer's ability to resist treatments

Endocrinology - Estrogen regulates fibulin-1 expression at transcriptional levels

Endocrinology - New findings in endocrinology described

Endocrinology - Tamoxifen exerts agonistic effects on clusterin in cancer tumors and metastases

Endometrial Hyperplasia - Anastrozole assessed as therapy in obese postmenopausal women

Endometrial Hyperplasia - Study suggests a link between serum bisphenol A levels and uterine disorder

Endometriosis - Biopharmaceutical company announces positive endometriosis trial results

Environmental Health - Lawmakers urge compensation for Colorado Rocky Flats workers

Environmental Pollution - Carcinogens in house dust can pose potential health risks

Enzymology - A key product of cytochrome p450 4A may regulate angiogenesis

Epstein-Barr Virus - Real-time Q-PCR distinguishes disease-associated EBV from incidental virus

Finance - Biopharma announces 2004 fourth quarter, year-end financial results

Finance - Cancer-focused biopharmaceutical company reports Q4, year end financial results

Finance - ECO-4601 developer enters into bought-deal private placment to raise $9M

Finance - Genetics-focused biopharmaceutical company announces full-year 2004 results