Oncogenesis
Chronic inflammation associated with tumorigenesis
Published in Cancer Weekly, April 5th, 2005
According to recent research from the United States, "Macrophage migration inhibitory factor (MIF) is implicated in the regulation of inflammation and cell growth. We previously showed that MIF is a potent modulator of p53- and E2F-dependent pathways that are activated in response to oncogenic signaling. Here, we characterize the functional link between MIF and E2F transcription factors."
"Our results demonstrate that MIF-deficient cells exhibit E2F-dependent growth alterations and reduced susceptibility to oncogenic transformation. The...
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Source: Cancer Weekly (2005-04-05)
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