Biological Therapies

Enamel matrix derivative inhibited breast cancer cell attachment to bone

Published in Cancer Weekly, April 12th, 2005

Enamel matrix derivative (EMD) might be a potent inhibitor and anti-adhesive agent against breast cancer cell attachment to bone.

"This study examined whether EMD inhibits the adhesion of cancer cells to bone. A typical breast cancer cell line, MCF-7, was used. Conditioned human osteosarcoma cell (Saos-2) medium was used as extracellular bone matrix (ECBM) to measure cell attachment," scientists in Japan reported.

"MCF-7 cells were incubated on ECBM-coated culture plates with or without soluble EMD, Arg-Gly-Asp (RGD) sequence blocking peptides, recombinant bone sialoprotein (rBSP), or specific integrin antibodies, and the attached cells were...

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Source: Cancer Weekly (2005-04-12)

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