Leukemia Therapy

Fibromodulin used as a novel tumor-associated antigen in leukemia

Published in Cancer Weekly, April 12th, 2005

Fibromodulin (FMOD) was used as a novel tumor-associated antigen in leukemia, enabling the expansion of autologous tumor-specific T cells.

"FMOD was shown to be highly overexpressed in chronic lymphocytic leukemia (CLL) cells compared with normal B lymphocytes by gene expression profiling. Therefore FMOD might serve as potential tumor-associated antigen (TAA) in CLL, enabling expansion of FMOD-specific T cells," scientists writing in the journal Blood reported.

"In CLL samples derived from 16 different patients, high expression of FMOD by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) was detectable in contrast to normal B...

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Source: Cancer Weekly (2005-04-12)

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