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Aging & Cancer Mortality
Variation in the human TP53 gene affected old-age survival and cancer mortality
April 19th, 2005
Researchers suggested that variation in the human TP53 gene affected old-age survival and cancer mortality. According to a study from the Netherlands, "Longevity may depend on a balance between tumor suppression and tissue renewal mechanisms [Campisi, J., 2003. Nat Rev Cancer 3(5), 339-349]. Mice with constitutively activated p53 are almost cancer free but their life span is reduced and accompanied by early tissue atrophy [Tyner et al., 2002. Nature 415(6867), 45-53]." "Replacement of arginine (Arg) by proline (Pro) at position 72 of human p53 decreases its apoptotic potential [Dumont et al., 2003. Nat. Genet. 33(3), 357-365], providing a tool to...
Source: Cancer Weekly (2005-04-19)
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